GABRA2

Description		gamma-aminobutyric acid type A receptor subunit alpha2
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GO Annotations	Cellular Component	Plasma Membrane Membrane Axon Dendrite Cytoplasmic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Dendrite Membrane Chloride Channel Complex Cell Projection Neuronal Cell Body Synapse Postsynaptic Membrane Inhibitory Synapse Postsynapse GABA-ergic Synapse Postsynaptic Specialization Membrane GABA-A Receptor Complex
	Molecular Function	Transmembrane Signaling Receptor Activity GABA-A Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Activity Protein Binding Benzodiazepine Receptor Activity GABA-gated Chloride Ion Channel Activity Signaling Receptor Activity Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Monoatomic Ion Transport Chloride Transport Gamma-aminobutyric Acid Signaling Pathway Monoatomic Ion Transmembrane Transport Synaptic Transmission, GABAergic Regulation Of Postsynaptic Membrane Potential Regulation Of Presynaptic Membrane Potential Chloride Transmembrane Transport Inhibitory Synapse Assembly
Pathways		GABA receptor activation GABA receptor activation
Drugs		Lorazepam Lorazepam Ethchlorvynol Enflurane Temazepam Temazepam Butabarbital Butalbital Butalbital Phenytoin Etomidate Talbutal Talbutal Pentobarbital Pentobarbital Olanzapine Clobazam Clobazam Meprobamate Meprobamate Eszopiclone Eszopiclone Alprazolam Alprazolam Secobarbital Zolpidem Metharbital Metharbital Chlordiazepoxide Chlordiazepoxide Amoxapine Adinazolam Adinazolam Lamotrigine Lamotrigine Thiopental Medroxyprogesterone acetate Clorazepic acid Clorazepic acid Midazolam Midazolam Flurazepam Flurazepam Isoflurane Primidone Primidone Halazepam Halazepam Propofol Diazepam Diazepam Oxazepam Oxazepam Methylphenobarbital Triazolam Triazolam Ethanol Zonisamide Methoxyflurane Memantine Clonazepam Clonazepam Methyprylon Halothane Desflurane Zopiclone Flumazenil Estazolam Estazolam Sevoflurane Quinidine barbiturate Amobarbital Aprobarbital Butobarbital Heptabarbital Hexobarbital Glutethimide Barbital Camazepam Camazepam Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione Delorazepam Delorazepam Flunitrazepam Flunitrazepam Ethyl loflazepate Ethyl loflazepate Cloxazolam Cloxazolam Bromazepam Bromazepam Clotiazepam Clotiazepam Fludiazepam Ketazolam Ketazolam Prazepam Prazepam Quazepam Quazepam Cinolazepam Cinolazepam Nitrazepam Nitrazepam Prasterone Taurine Pagoclone Ganaxolone Adipiplon Brotizolam Brotizolam Stiripentol Etizolam Etizolam Thiocolchicoside Brexanolone Apalutamide Remimazolam Remimazolam 1,2-Benzodiazepine 1,2-Benzodiazepine Pinazepam Pinazepam Medazepam Medazepam Loprazolam Loprazolam Doxefazepam Doxefazepam Lormetazepam Lormetazepam 5,7,2′-trihydroxy-6,8-dimethoxyflavone AZD-7325 Nordazepam Nordazepam Oxazepam acetate Oxazepam acetate Cinazepam Cinazepam Bentazepam Bentazepam Mexazolam Mexazolam
Diseases
GWAS		Adventurousness ( 30643258) Epilepsy ( 25087078) General risk tolerance (MTAG) ( 30643258) Generalized epilepsy ( 30531953) Systolic blood pressure ( 30224653)
Interacting Genes		2 interacting genes: GABRG2 UBQLN1
Entrez ID		2555
HPRD ID		11747
Ensembl ID		ENSG00000151834
Uniprot IDs		E9PBQ7 G5E9Z6 P47869
PDB IDs		9CRV 9CSB 9CT0 9CTJ 9CTV 9CX7 9CXB 9CXC
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Store-operated Calcium Channel Activity Cytoplasmic Vesicle GABA-A Receptor Activity Cellular Response To Histamine GABA-A Receptor Complex Response To Histamine Inhibitory Synapse Assembly Benzodiazepine Receptor Activity GABA-gated Chloride Ion Channel Activity Aggrephagy Positive Regulation Of ERAD Pathway Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Toll-like Receptor 3 Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Negative Regulation Of Transporter Activity Regulation Of ERAD Pathway Postsynaptic Specialization Membrane Dendrite Membrane Synaptic Transmission, GABAergic Aggresome Extracellular Ligand-gated Monoatomic Ion Channel Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Calcium Ion Transmembrane Transport Chloride Channel Complex Negative Regulation Of Calcium Ion Transport Autophagosome Maturation Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Proteasome Complex Chloride Channel Activity Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Post-embryonic Development Chloride Transmembrane Transport Regulation Of Postsynaptic Membrane Potential Synapse Assembly GABA-ergic Synapse Autophagosome Kinase Binding Regulation Of Transmembrane Transporter Activity Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Organization Autophagosome Assembly Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway ERAD Pathway Negative Regulation Of Monoatomic Ion Transport Regulation Of Monoatomic Ion Transmembrane Transporter Activity Chloride Transport
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