LCORL and MIR206

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		LCORL	MIR206
Description		ligand dependent nuclear receptor corepressor like	microRNA 206
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	RISC Complex
	Molecular Function	DNA Binding Protein Binding Histone Methyltransferase Binding	MRNA 3'-UTR Binding Protein Binding MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Positive Regulation Of Cell Fate Commitment Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Myotube Differentiation Positive Regulation Of Cholesterol Efflux Negative Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Tumor Necrosis Factor Production MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Lipid Biosynthetic Process Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Cholesterol Efflux Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Amyloid-beta Formation
Pathways
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) ( 24025145) Alanine aminotransferase levels ( 33547301) Alzheimer's disease progression score ( 29860282) Appendicular lean mass ( 33097823) Birth length ( 25281659) Birth weight ( 27680694 31043758 23202124) BMI at 1 year old ( 31575865) BMI at 1.5 years old ( 31575865) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Chronotype ( 30696823) Colorectal cancer (diet interaction) ( 24743840) Diverticular disease ( 30177863) Familial squamous cell lung carcinoma ( 29924316) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431) HDL cholesterol levels ( 32203549) HDL cholesterol levels in HIV infection ( 33109212) Heel bone mineral density ( 30598549) Height ( 31562340 33713608 34270706 18391952 18391951 28552196 19343178 20189936 20881960 21998595 28270201 22021425 23563607 25429064 25282103) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172 25673412) Infant length ( 25281659) Offspring birth weight ( 31043758) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Refractive error ( 32231278) Reticulocyte fraction of red cells ( 32888494) Systolic blood pressure ( 30224653 30578418) Triglyceride levels ( 32203549) Type 2 diabetes ( 30297969) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 34021172 28552196) Weight ( 28552196) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		3 interacting genes: CTBP2 MAGEA6 MIR206	78 interacting genes: ADARB1 AIMP1 AQR C1QBP CELF1 CPSF1 CSTF1 DARS1 DDX1 DDX21 DDX3X DHX36 DHX37 EIF2AK2 EPRS1 ERAL1 FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LCORL LIN28A LIN28B LRPPRC MARS1 MATR3 NOL4L NONO NUDT21 PDCD11 PGAM5 PLOD1 PRMT1 PTBP1 PTBP3 PUM1 QARS1 RARS1 RBFOX2 RBM14 RBM4 RTCB SF3A3 SF3B1 SF3B2 SF3B3 SFPQ SUGP2 SYNCRIP TAF15 TRA2A TRA2B TRIM25 U2SURP UPF1 UTP20 YBX1 YBX3 ZFR ZNF346
Entrez ID		254251	406989
HPRD ID		10088
Ensembl ID		ENSG00000178177	ENSG00000207604
Uniprot IDs		A0A1B0GVP4 A0A6Q8PHE0 A0A6Q8PHT2 B4DSW0 Q8N3X6
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription Repressor Complex Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process White Fat Cell Differentiation Viral Genome Replication Transcription Coregulator Binding Regulation Of Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process NAD Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Negative Regulation Of Metabolic Process Transcription Corepressor Binding Positive Regulation Of Myotube Differentiation Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Neuroinflammatory Response Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Amyloid-beta Formation Negative Regulation Of Interleukin-6 Production Regulation Of Myotube Differentiation Positive Regulation Of Cholesterol Efflux Negative Regulation Of Cell Adhesion Molecule Production Positive Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Lipid Biosynthetic Process MRNA Base-pairing Post-transcriptional Repressor Activity Negative Regulation Of Cholesterol Efflux Regulation Of Amyloid-beta Formation Negative Regulation Of Lipid Transport Regulation Of Cholesterol Transport Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Cell Fate Commitment Regulation Of Cell Fate Commitment Negative Regulation Of Blood Vessel Endothelial Cell Migration MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Cholesterol Efflux Positive Regulation Of Striated Muscle Cell Differentiation Regulation Of Neuroinflammatory Response Negative Regulation Of Cholesterol Transport Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Amide Metabolic Process Regulation Of Cell Adhesion Molecule Production Positive Regulation Of Cholesterol Transport Positive Regulation Of Interleukin-1 Production Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Muscle Cell Differentiation Regulation Of Amide Metabolic Process	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process MRNA Processing RNA Splicing MRNA Metabolic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Binding Regulation Of MRNA Metabolic Process Regulation Of RNA Splicing Macromolecule Metabolic Process Nucleoplasm Aminoacyl-tRNA Synthetase Multienzyme Complex MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleus Catalytic Step 2 Spliceosome Spliceosomal Complex Cytoplasmic Stress Granule Post-transcriptional Regulation Of Gene Expression Ribonucleoprotein Complex MRNA 3'-UTR Binding Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Translation MiRNA Binding Negative Regulation Of RNA Catabolic Process Regulation Of RNA Stability Negative Regulation Of Translation Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of MRNA Stability TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity TRNA Aminoacylation MRNA Stabilization Regulation Of Gene Expression Positive Regulation Of Gene Expression Nucleolus Positive Regulation Of Cytoplasmic Translation Regulation Of Macromolecule Biosynthetic Process Ligase Activity Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process
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