IFI6 and CIB1

Number of citations of the paper that reports this interaction (PMID 15685448)
16

Data Source:
HPRD (two hybrid)

		IFI6	CIB1
Gene Name		interferon, alpha-inducible protein 6	calcium and integrin binding 1 (calmyrin)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Plasma Membrane Integral Component Of Membrane	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Golgi Apparatus Centrosome Plasma Membrane Membrane Apical Plasma Membrane Lamellipodium Growth Cone Vesicle Filopodium Tip Ruffle Membrane Sarcolemma Neuron Projection Neuronal Cell Body Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Cell Periphery
	Molecular Function	Protein Binding	Calcium Ion Binding Protein Binding Ras GTPase Binding Protein Anchor Ion Channel Binding
	Biological Process	Release Of Cytochrome C From Mitochondria Immune Response Cytokine-mediated Signaling Pathway Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Mitochondrial Depolarization Type I Interferon Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Angiogenesis Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cell-matrix Adhesion Response To Ischemia Double-strand Break Repair Apoptotic Process Cellular Response To DNA Damage Stimulus Negative Regulation Of Microtubule Depolymerization Endomitotic Cell Cycle Cell Adhesion Spermatid Development Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Negative Regulation Of Neuron Projection Development Platelet Formation Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Cytoplasmic Microtubule Organization Positive Regulation Of Cell Adhesion Mediated By Integrin Thrombopoietin-mediated Signaling Pathway Regulation Of Cell Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of Metalloenzyme Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Cell Division Regulation Of Cell Division Negative Regulation Of Protein Kinase B Signaling Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Protein Targeting To Membrane Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Male Germ Cell Proliferation
Pathways		Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: APP CIB1	21 interactors: AURKB CDK4 EXOSC10 FEZ1 IFI6 ITGA2B ITGB3 NBR1 NRIP1 PAX3 PLK2 PLK3 PRKDC PSEN1 PSEN2 PTK2 RAC3 TERT UBR5 WAS ZDHHC17
Entrez ID		2537	10519
HPRD ID		00959	03800
Ensembl ID		ENSG00000126709
Uniprot IDs		P09912	H6WJF3 Q99828
PDB IDs			1DGU 1DGV 1XO5 1Y1A 2L4H 2L4I 2LM5
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Neuron Differentiation Positive Regulation Of Male Germ Cell Proliferation Negative Regulation Of Neurogenesis Thrombopoietin-mediated Signaling Pathway Synaptic Growth At Neuromuscular Junction Negative Regulation Of Cell Development Collateral Sprouting In Absence Of Injury Regulation Of Male Germ Cell Proliferation Endomitotic Cell Cycle Negative Regulation Of Megakaryocyte Differentiation Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Axon Choice Point Recognition Regulation Of Neuron Differentiation Positive Regulation Of Metalloenzyme Activity Positive Regulation Of Sprouting Angiogenesis Regulation Of Growth Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Neuron Remodeling Regulation Of Neurogenesis Cell Morphogenesis Involved In Differentiation Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Cell Differentiation Regulation Of Protein Kinase Activity Microtubule-based Process Regulation Of Kinase Activity Sexual Reproduction Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Cell Development Negative Regulation Of Protein Metabolic Process Positive Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Sprouting Angiogenesis Cellular Copper Ion Homeostasis Regulation Of Megakaryocyte Differentiation Positive Regulation Of Blood Vessel Endothelial Cell Migration Apoptotic Process Platelet Formation Platelet Morphogenesis Copper Ion Homeostasis Suckling Behavior Programmed Cell Death Reproduction Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Cell Death Death Cell Morphogenesis	Cellular Response To Stimulus Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Regulation Of Apoptotic Process Response To Stimulus Regulation Of Cell Death Homotypic Cell-cell Adhesion Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Signal Transduction Cell Communication Negative Regulation Of Cell Death Cell Activation Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Neuron Differentiation Generation Of Neurons Developmental Process Single Organismal Cell-cell Adhesion Signaling Neurogenesis Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Response To Stress Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Protein Binding Nervous System Development Cell Development Neuron Development Regulation Of Cellular Process Apoptotic Process Programmed Cell Death Regulation Of Cellular Component Organization Axon Guidance Organelle Organization Cell Death Movement Of Cell Or Subcellular Component Death Positive Regulation Of Cellular Metabolic Process Amyloid Precursor Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Multicellular Organismal Development Positive Regulation Of Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Embryo Development Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Cell Cycle
Tagcloud ?		adenomas aging ai balanced ccne1 cdk1 cdk6 colonic colorectal crc crcs dependency differently hgu133plus2 juvenile mi mitosis mki67 n1 n2 n3 n4 opposed perturbed rejuvenescence socs3 tnfsf10 tunel uncontrolled	accelerated ask1 ca cytosolic depleting depolarization dysregulation efflux excessive folding homeostasis inactivated influx inositol insp3 insp3r ire1alpha mitochondrion otherwise perturbation posttranslational reservoir secretory sh superoxide sy5y traf2 triggers underlies
Tagcloud (Difference) ?		adenomas aging ai balanced ccne1 cdk1 cdk6 colonic colorectal crc crcs dependency differently hgu133plus2 juvenile mi mitosis mki67 n1 n2 n3 n4 opposed perturbed rejuvenescence socs3 tnfsf10 tunel uncontrolled	accelerated ask1 ca cytosolic depleting depolarization dysregulation efflux excessive folding homeostasis inactivated influx inositol insp3 insp3r ire1alpha mitochondrion otherwise perturbation posttranslational reservoir secretory sh superoxide sy5y traf2 triggers underlies
Tagcloud (Intersection) ?