IFI6 and CIB1

Number of citations of the paper that reports this interaction (PubMedID 15685448)
34

Data Source:
HPRD (two hybrid)

		IFI6	CIB1
Description		interferon alpha inducible protein 6	calcium and integrin binding 1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Mitochondrial Membrane	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Golgi Apparatus Centrosome Cytoskeleton Plasma Membrane Membrane Apical Plasma Membrane Nuclear Body Lamellipodium Axon Growth Cone Vesicle Filopodium Tip Ruffle Membrane Sarcolemma Cell Projection Neuron Projection Neuronal Cell Body Perikaryon Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery
	Molecular Function	Protein Binding Molecular Adaptor Activity	Magnesium Ion Binding Calcium Ion Binding Protein Binding Calcium-dependent Protein Kinase Inhibitor Activity Protein Serine/threonine Kinase Inhibitor Activity Small GTPase Binding Protein-membrane Adaptor Activity Transmembrane Transporter Binding Metal Ion Binding
	Biological Process	Immune System Process Apoptotic Process Immune Response Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Innate Immune Response Defense Response To Virus Negative Regulation Of Mitochondrial Depolarization Reactive Oxygen Species Metabolic Process Negative Regulation Of Release Of Cytochrome C From Mitochondria Intrinsic Apoptotic Signaling Pathway Cellular Response To Virus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Angiogenesis Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cell-matrix Adhesion Response To Ischemia Double-strand Break Repair Apoptotic Process DNA Damage Response Negative Regulation Of Microtubule Depolymerization Endomitotic Cell Cycle Cell Adhesion Spermatogenesis Spermatid Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Neuron Projection Development Cell Differentiation Platelet Formation Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Cytoplasmic Microtubule Organization Positive Regulation Of Cell Adhesion Mediated By Integrin Thrombopoietin-mediated Signaling Pathway Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of NF-kappaB Transcription Factor Activity Cell Division Regulation Of Cell Division Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Protein Targeting To Membrane Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Protein Localization To Plasma Membrane Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Male Germ Cell Proliferation
Pathways		Interferon alpha/beta signaling Modulation of host responses by IFN-stimulated genes
Drugs			Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Body mass index ( 28892062)
Interacting Genes		2 interacting genes: APP CIB1	38 interacting genes: AURKB CALCB CD27 CDK4 CEACAM6 EIF4G1 ELAPOR1 EXOSC10 FEZ1 FUCA1 GLIS3 IFI6 ITGA2B LSS MAP3K5 NBR1 NCK2 NME4 NRIP1 ONECUT3 PAX3 PAX7 PLK2 PLK3 PRKDC PSEN1 PSEN2 PTK2 RAC3 SCAF1 SSX7 TERT TMEM95 TSGA10IP UBR5 WAS ZBTB49 ZDHHC17
Entrez ID		2537	10519
HPRD ID		00959	03800
Ensembl ID		ENSG00000126709	ENSG00000185043
Uniprot IDs		A0A348GSI1 P09912	A0A140VK09 Q99828
PDB IDs			1DGU 1DGV 1XO5 1Y1A 2L4H 2L4I 2LM5 6OCX 6OD0
Enriched GO Terms of Interacting Partners?		Response To Nerve Growth Factor Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Calcium-mediated Signaling Regulation Of Calcium-mediated Signaling Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Growth Cone Perikaryon Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Male Germ Cell Proliferation Acetylcholine Receptor Activator Activity PTB Domain Binding Positive Regulation Of Phosphate Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Establishment Of Protein Localization Regulation Of ERK1 And ERK2 Cascade Response To Growth Factor Endosome To Plasma Membrane Transport Vesicle Cellular Response To Growth Factor Stimulus Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Endomitotic Cell Cycle Calcium-dependent Protein Kinase Inhibitor Activity Neuron Projection Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Axon Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Regulation Of Supramolecular Fiber Organization Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Male Germ Cell Proliferation Regulation Of Spontaneous Synaptic Transmission Positive Regulation Of MAPK Cascade NMDA Selective Glutamate Receptor Signaling Pathway	Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Kinetochore Kinase Activity Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Aspartic Endopeptidase Activity, Intramembrane Cleaving Protein Binding Protein Kinase Activity Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Translation In Response To Stress Positive Regulation Of RNA Metabolic Process Gamma-secretase Complex Protein Serine Kinase Activity Signal Complex Assembly Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Notch Receptor Processing Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Organelle Organization Regulation Of Translation In Response To Endoplasmic Reticulum Stress Amyloid-beta Formation Protein Serine/threonine Kinase Activity Positive Regulation Of Intracellular Transport Positive Regulation Of Biosynthetic Process Dorsal/ventral Neural Tube Patterning Regulation Of Cell Cycle Phase Transition Cell Cycle Phase Transition Cellular Response To Stress Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Immune System Process Regulation Of RNA Metabolic Process T Cell Activation Centrosome Regulation Of Cellular Component Organization Regulation Of DNA-templated Transcription Negative Regulation Of CGAS/STING Signaling Pathway Regulation Of RNA Biosynthetic Process Mitotic G1/S Transition Checkpoint Signaling Amyloid Precursor Protein Catabolic Process Apoptotic Signaling Pathway Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Mitotic Cell Cycle G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Anoikis Maturation Of 5.8S RRNA
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