LCE1E and ALPP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LCE1E	ALPP
Description		late cornified envelope 1E	alkaline phosphatase, placental
Image		No pdb structure
GO Annotations	Cellular Component		Plasma Membrane Cell Surface Membrane Side Of Membrane
	Molecular Function	Protein Binding Identical Protein Binding	Magnesium Ion Binding Alkaline Phosphatase Activity Protein Binding Zinc Ion Binding Hydrolase Activity Phosphatase Activity Metal Ion Binding
	Biological Process	Epidermis Development Keratinization
Pathways		Formation of the cornified envelope	Intra-Golgi traffic
Drugs			Calcium METHYL-PHOSPHONIC ACID MONO-(4-NITRO-PHENYL) ESTER
Diseases
GWAS		Asthma ( 31619474) Inflammatory skin disease ( 25574825)	Blood protein levels ( 30072576) Height ( 19570815) Refractive error ( 32231278)
Interacting Genes		67 interacting genes: ALPP CATSPER1 CYSRT1 EFEMP2 FAM9A FUCA2 GRN KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-3 KRTAP12-4 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-8 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1F LCE2B LCE2C LCE2D LCE3B LCE4A LCE5A MACO1 MEOX2 NBPF19 NECTIN2 NOTCH2NLA NTAQ1 PIAS2 RGS17 RGS20 RNF4 SMCP SPRY1 TGM1 TRIM42 ZCCHC7	47 interacting genes: ADAMTSL4 ALPG CRCT1 CREB5 CXCL5 CYSRT1 FBXO34 GEMIN4 GPLD1 GSC2 HOXA1 IGFBP6 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-8 KRTAP4-12 KRTAP5-9 KRTAP9-3 LATS1 LCE1B LCE1C LCE1D LCE1E LCE1F LCE2C LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LELP1 MEOX2 NBPF19 NLGN3 NOTCH2NLA NR4A3 NUFIP2 OTX1 PIGK POU4F2 RGS19 RGS20 SMCP TGM1
Entrez ID		353135	250
HPRD ID		13969	01379
Ensembl ID		ENSG00000186226	ENSG00000163283
Uniprot IDs		Q5T753	B2R7C7 P05187
PDB IDs			1EW2 1ZEB 1ZED 1ZEF 2GLQ 3MK0 3MK1 3MK2
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Keratinization Epidermis Development Hair Cycle Tissue Development Cytosol Protein Binding Identical Protein Binding	Keratinization Epidermis Development Tissue Development Intermediate Filament Keratin Filament Identical Protein Binding
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