CNOT6L and TNRC6A

Number of citations of the paper that reports this interaction (PMID 21984185)
56

Data Source:
BioGRID (pull down, affinity chromatography technology)

		CNOT6L	TNRC6A
Gene Name		CCR4-NOT transcription complex, subunit 6-like	trinucleotide repeat containing 6A
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol CCR4-NOT Complex	Cytoplasmic MRNA Processing Body Nucleoplasm Cytosol Micro-ribonucleoprotein Complex
	Molecular Function	Poly(A)-specific Ribonuclease Activity Protein Binding Metal Ion Binding	Nucleotide Binding Protein Binding Poly(A) RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Translation Positive Regulation Of Cell Proliferation Gene Expression Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Gene Silencing By RNA MRNA Destabilization RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Epidermal Growth Factor Receptor Signaling Pathway Notch Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Starvation Gene Expression Posttranscriptional Gene Silencing Gene Silencing By MiRNA Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Fc-epsilon Receptor Signaling Pathway Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling
Pathways		Deadenylation of mRNA Deadenylation-dependent mRNA decay	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Regulatory RNA pathways Cellular Senescence Signaling by Wnt Signaling by EGFRvIII in Cancer Oncogene Induced Senescence Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade Pre-NOTCH Transcription and Translation PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Pre-NOTCH Expression and Processing Post-transcriptional silencing by small RNAs Innate Immune System Signaling by PDGF Transcriptional regulation by small RNAs Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by NOTCH Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR beta-catenin independent WNT signaling Signaling by ERBB2 Signaling by EGFR Ca2+ pathway Oxidative Stress Induced Senescence Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs
Diseases
GWAS			Type 2 diabetes (dietary heme iron intake interaction) ( 23386860)
Protein-Protein Interactions		3 interactors: LZTR1 TNRC6A ZSCAN1	7 interactors: AGO4 CNOT6L CNOT7 PAN2 TRIM65 TRIP13 WNK1
Entrez ID		246175	27327
HPRD ID		10841	11640
Ensembl ID		ENSG00000138767	ENSG00000090905
Uniprot IDs		B4E2S0 Q96LI5	Q8NDV7
PDB IDs		3NGN 3NGO 3NGQ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Translation Involved In Gene Silencing By MiRNA	Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Gene Silencing By RNA MRNA 3'-end Processing Gene Silencing RNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis Aromatic Compound Catabolic Process MRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process Cellular Macromolecule Catabolic Process Regulation Of Translation Gene Silencing By MiRNA Posttranscriptional Gene Silencing Nucleic Acid Phosphodiester Bond Hydrolysis MRNA Processing Posttranscriptional Regulation Of Gene Expression RNA Metabolic Process RNA Processing Gene Expression Catabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Gene Expression, Epigenetic Negative Regulation Of Pancreatic Juice Secretion Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Nucleobase-containing Compound Metabolic Process Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cytoplasmic MRNA Processing Body Assembly MRNA Destabilization Cytoplasmic MRNA Processing Body Assembly Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening RNA Destabilization Negative Regulation Of Gene Expression Positive Regulation Of Systemic Arterial Blood Pressure Nitrogen Compound Metabolic Process Female Meiosis I Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of MRNA 3'-end Processing Positive Regulation Of MRNA Catabolic Process Synaptonemal Complex Assembly Cellular Metabolic Process
Tagcloud ?			arrest bim cdkn1a cdkn1c clusters derepressed derepression disruption endoderm gt gw182 lats1 lats2 microrna mirna mirnas p21 p27 proper pten rb1 rbl sac selectively silencing suppression targets yolk
Tagcloud (Difference) ?			arrest bim cdkn1a cdkn1c clusters derepressed derepression disruption endoderm gt gw182 lats1 lats2 microrna mirna mirnas p21 p27 proper pten rb1 rbl sac selectively silencing suppression targets yolk
Tagcloud (Intersection) ?