TMEM50A and ABCG4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM50A	ABCG4
Description		transmembrane protein 50A	ATP binding cassette subfamily G member 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Neuronal Cell Body Glial Cell Projection	Endosome Plasma Membrane Endosome Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle
	Molecular Function	Protein Binding	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity ABC-type Sterol Transporter Activity Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Dimerization Activity ABC-type Transporter Activity
	Biological Process	Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway	Regulation Of DNA-templated Transcription Lipid Transport Positive Regulation Of Cholesterol Efflux Sterol Transport Cholesterol Efflux Cholesterol Homeostasis Positive Regulation Of Cholesterol Biosynthetic Process Transmembrane Transport Cellular Response To High Density Lipoprotein Particle Stimulus Cellular Response To Leukemia Inhibitory Factor
Pathways			ABC transporters in lipid homeostasis
Drugs
Diseases
GWAS		Erythrocyte sedimentation rate ( 21700265) Mean corpuscular hemoglobin concentration ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Lymphocyte count ( 27863252) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 27863252 32888494)
Interacting Genes		13 interacting genes: ABCG4 AQP6 COMT HLA-DPA1 LEPROT LEPROTL1 REEP4 SLC30A8 SYT9 TMEM14B TMEM31 TRAPPC14 XRN1	6 interacting genes: ABCG1 GPR152 PLEKHF2 SGTB TMEM50A ZDHHC17
Entrez ID		23585	64137
HPRD ID		05636	12130
Ensembl ID		ENSG00000183726	ENSG00000172350
Uniprot IDs		B7Z5M7 O95807 Q7RU07	Q9H172
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Growth Hormone Receptor Signaling Pathway Regulation Of Growth Hormone Receptor Signaling Pathway Nitrate Transmembrane Transporter Activity Membrane Norepinephrine Secretion Response To Peptide Catechol O-methyltransferase Activity Cholesterol Efflux Response To Cytokine Transport Vesicle Membrane Endosome Transport Via Multivesicular Body Sorting Pathway Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Sorting Pathway Late Endosome To Vacuole Transport Cellular Response To Puromycin Cellular Response To Cycloheximide PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Cellular Response To Phosphate Starvation Cholesterol Transport Clathrin-coated Endocytic Vesicle Membrane Endosome Membrane ABC-type Sterol Transporter Activity Sterol Transport Endosome
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