ABCG4 and ABCG1

Number of citations of the paper that reports this interaction (PubMedID 15240127)
0

Data Source:
HPRD (in vitro, in vivo)

		ABCG4	ABCG1
Description		ATP binding cassette subfamily G member 4	ATP binding cassette subfamily G member 1
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Plasma Membrane Endosome Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle	Golgi Membrane Nucleoplasm Mitochondrion Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Membrane Recycling Endosome
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity ABC-type Sterol Transporter Activity Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Dimerization Activity ABC-type Transporter Activity	Nucleotide Binding Protein Binding ATP Binding Phospholipid Binding Cholesterol Binding ATP Hydrolysis Activity Toxin Transmembrane Transporter Activity ABC-type Sterol Transporter Activity Protein Homodimerization Activity ADP Binding Protein Heterodimerization Activity Protein Dimerization Activity Phosphatidylcholine Floppase Activity Cholesterol Transfer Activity Floppase Activity ABC-type Transporter Activity
	Biological Process	Regulation Of DNA-templated Transcription Lipid Transport Positive Regulation Of Cholesterol Efflux Sterol Transport Cholesterol Efflux Cholesterol Homeostasis Positive Regulation Of Cholesterol Biosynthetic Process Transmembrane Transport Cellular Response To High Density Lipoprotein Particle Stimulus Cellular Response To Leukemia Inhibitory Factor	Lipid Transport Cholesterol Metabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Efflux Negative Regulation Of Cholesterol Storage Negative Regulation Of Lipid Storage Cholesterol Transport Intracellular Cholesterol Transport Cholesterol Efflux Phospholipid Efflux Response To Lipid Lipid Translocation Low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Glycoprotein Transport Cholesterol Homeostasis Amyloid Precursor Protein Catabolic Process Reverse Cholesterol Transport Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Protein Secretion Transmembrane Transport Phospholipid Homeostasis Cellular Response To High Density Lipoprotein Particle Stimulus Regulation Of Cholesterol Metabolic Process Positive Regulation Of Amyloid-beta Formation Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane
Pathways		ABC transporters in lipid homeostasis	ABC transporters in lipid homeostasis HDL remodeling NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs			ATP
Diseases
GWAS		Lymphocyte count ( 27863252) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 27863252 32888494)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Dementia and core Alzheimer's disease neuropathologic changes ( 25188341) Eating disorder in bipolar disorder ( 26433762) Gout ( 22179738) HDL cholesterol levels ( 32203549) Idiopathic osteonecrosis of the femoral head ( 28000841) Neuritic plaque ( 25188341)
Interacting Genes		6 interacting genes: ABCG1 GPR152 PLEKHF2 SGTB TMEM50A ZDHHC17	2 interacting genes: ABCG4 AQP6
Entrez ID		64137	9619
HPRD ID		12130	04355
Ensembl ID		ENSG00000172350	ENSG00000160179
Uniprot IDs		Q9H172	P45844
PDB IDs			7FDV 7OZ1 7R8C 7R8D 7R8E
Enriched GO Terms of Interacting Partners?			PH-gated Chloride Channel Activity Nitrate Transmembrane Transporter Activity Nitrate Transmembrane Transport Chondroitin Sulfate Proteoglycan Binding ABC-type Sterol Transporter Activity Cytoplasmic Vesicle Membrane Cellular Response To High Density Lipoprotein Particle Stimulus Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Negative Regulation Of Receptor Binding Monoatomic Anion Channel Activity Renal Water Transport Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Ammonium Transmembrane Transport Ammonium Channel Activity N-acetyl-beta-D-glucosaminide Beta-(1,3)-galactosyltransferase Activity Water Channel Activity Carbon Dioxide Transport One-carbon Compound Transport Water Transport Negative Regulation Of Protein Binding Regulation Of Neuron Projection Regeneration Neuron Projection Regeneration Regulation Of Axon Regeneration Transmembrane Receptor Protein Tyrosine Phosphatase Activity Peptidyl-tyrosine Dephosphorylation Synaptic Membrane Adhesion Hexosyltransferase Activity Oligosaccharide Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Efflux Cholesterol Efflux Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Metabolic Process Fluid Transport Positive Regulation Of Steroid Biosynthetic Process Positive Regulation Of Cholesterol Transport Cellular Response To Lipoprotein Particle Stimulus Channel Activity ABC-type Transporter Activity Positive Regulation Of Steroid Metabolic Process Regulation Of Protein Binding Regulation Of Cholesterol Efflux Regulation Of Cholesterol Metabolic Process
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