TMEM50A and LEPROT

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM50A	LEPROT
Description		transmembrane protein 50A	leptin receptor overlapping transcript
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Neuronal Cell Body Glial Cell Projection	Golgi Membrane Endosome Golgi Apparatus Endosome Membrane Membrane
	Molecular Function	Protein Binding	Signaling Receptor Binding Protein Binding
	Biological Process	Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway	Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Protein Localization To Cell Surface
Pathways
Drugs
Diseases
GWAS		Erythrocyte sedimentation rate ( 21700265) Mean corpuscular hemoglobin concentration ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	BMI at adiposity peak ( 31840077)
Interacting Genes		13 interacting genes: ABCG4 AQP6 COMT HLA-DPA1 LEPROT LEPROTL1 REEP4 SLC30A8 SYT9 TMEM14B TMEM31 TRAPPC14 XRN1	11 interacting genes: AQP6 C1GALT1 GJA5 PLPPR1 SLC7A1 SMO SYNGR1 TMEM120A TMEM50A TMX2 YIPF1
Entrez ID		23585	54741
HPRD ID		05636	13987
Ensembl ID		ENSG00000183726	ENSG00000213625
Uniprot IDs		B7Z5M7 O95807 Q7RU07	A0A087X0N2 O15243
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Growth Hormone Receptor Signaling Pathway Regulation Of Growth Hormone Receptor Signaling Pathway Nitrate Transmembrane Transporter Activity Membrane Norepinephrine Secretion Response To Peptide Catechol O-methyltransferase Activity Cholesterol Efflux Response To Cytokine Transport Vesicle Membrane Endosome Transport Via Multivesicular Body Sorting Pathway Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Sorting Pathway Late Endosome To Vacuole Transport Cellular Response To Puromycin Cellular Response To Cycloheximide PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Cellular Response To Phosphate Starvation Cholesterol Transport Clathrin-coated Endocytic Vesicle Membrane Endosome Membrane ABC-type Sterol Transporter Activity Sterol Transport Endosome	Membrane Atrial Septum Morphogenesis Nitrate Transmembrane Transporter Activity Gap Junction Channel Activity Involved In Purkinje Myocyte-ventricular Cardiac Muscle Cell Electrical Coupling Mitral Valve Development Septum Primum Development Gap Junction Channel Activity Involved In Atrial Cardiac Muscle Cell-AV Node Cell Electrical Coupling Atrial Ventricular Junction Remodeling Gap Junction Channel Activity Involved In Bundle Of His Cell-Purkinje Myocyte Electrical Coupling Positive Regulation Of Cell Communication By Chemical Coupling Atrial Cardiac Muscle Cell To AV Node Cell Communication By Electrical Coupling Vasomotion Purkinje Myocyte To Ventricular Cardiac Muscle Cell Communication By Electrical Coupling Regulation Of Purkinje Myocyte Action Potential Mesenchymal To Epithelial Transition Involved In Metanephric Renal Vesicle Formation Ventral Midline Determination PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Gap Junction Channel Activity Involved In SA Node Cell-atrial Cardiac Muscle Cell Electrical Coupling Cardiac Septum Morphogenesis Foramen Ovale Closure Bundle Of His Cell To Purkinje Myocyte Communication By Electrical Coupling Regulation Of Bundle Of His Cell Action Potential Cell Communication By Chemical Coupling Pulmonary Valve Formation SA Node Cell To Atrial Cardiac Muscle Cell Communication By Electrical Coupling Atrial Cardiac Muscle Cell To AV Node Cell Communication Lysine Transport L-histidine Import Across Plasma Membrane Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase Activity Odontogenesis Bundle Of His Cell To Purkinje Myocyte Communication Regulation Of Renin Secretion Into Blood Stream Gap Junction Channel Activity Involved In Cardiac Conduction Electrical Coupling Regulation Of AV Node Cell Action Potential L-ornithine Transmembrane Transport L-ornithine Transmembrane Transporter Activity Contact Inhibition Pancreas Morphogenesis Renal System Process Regulation Of Atrial Cardiac Muscle Cell Action Potential Gap Junction Channel Activity Involved In AV Node Cell-bundle Of His Cell Electrical Coupling SA Node Cell To Atrial Cardiac Muscle Cell Communication Negative Regulation Of Glomerular Filtration AV Node Cell To Bundle Of His Cell Communication By Electrical Coupling Ornithine Transport L-arginine Import Across Plasma Membrane Detection Of Cell Density Response To Inositol Coenzyme A Binding
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