LEPROT and PLPPR1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		LEPROT	PLPPR1
Name		leptin receptor overlapping transcript	phospholipid phosphatase related 1
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endosome Golgi Apparatus Endosome Membrane Membrane	Nucleoplasm Plasma Membrane Membrane Cell Projection Neuron Projection
	Molecular Function	Signaling Receptor Binding Protein Binding	Protein Binding Phosphatidate Phosphatase Activity Lysophosphatidic Acid Phosphatase Activity
	Biological Process	Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Protein Localization To Cell Surface	Phospholipid Metabolic Process Signal Transduction Nervous System Development Phospholipid Dephosphorylation
Pathways		None	Lysosphingolipid and LPA receptors
GWAS		BMI at adiposity peak ( 31840077 )	Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678 ) Hip circumference adjusted for BMI ( 28552196 ) Triglyceride levels in HIV infection ( 33109212 )
Novel Interactors		None recorded	1 novel interactors: ERP44
Interacting Genes		11 interacting genes: AQP6 C1GALT1 GJA5 PLPPR1 SLC7A1 SMO SYNGR1 TMEM120A TMEM50A TMX2 YIPF1	5 interacting genes: LEPROT PLN SERP1 SLC30A2 TMPPE
Entrez ID		54741	54886
HPRD ID		13987	17906
Ensembl ID		ENSG00000213625	ENSG00000148123
Uniprot IDs		A0A087X0N2 O15243	Q8TBJ4
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Membrane Atrial Septum Morphogenesis Nitrate Transmembrane Transporter Activity Gap Junction Channel Activity Involved In Purkinje Myocyte-ventricular Cardiac Muscle Cell Electrical Coupling Mitral Valve Development Septum Primum Development Gap Junction Channel Activity Involved In Atrial Cardiac Muscle Cell-AV Node Cell Electrical Coupling Atrial Ventricular Junction Remodeling Gap Junction Channel Activity Involved In Bundle Of His Cell-Purkinje Myocyte Electrical Coupling Positive Regulation Of Cell Communication By Chemical Coupling Atrial Cardiac Muscle Cell To AV Node Cell Communication By Electrical Coupling Vasomotion Purkinje Myocyte To Ventricular Cardiac Muscle Cell Communication By Electrical Coupling Regulation Of Purkinje Myocyte Action Potential Mesenchymal To Epithelial Transition Involved In Metanephric Renal Vesicle Formation Ventral Midline Determination PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Gap Junction Channel Activity Involved In SA Node Cell-atrial Cardiac Muscle Cell Electrical Coupling Cardiac Septum Morphogenesis Foramen Ovale Closure Bundle Of His Cell To Purkinje Myocyte Communication By Electrical Coupling Regulation Of Bundle Of His Cell Action Potential Cell Communication By Chemical Coupling Pulmonary Valve Formation SA Node Cell To Atrial Cardiac Muscle Cell Communication By Electrical Coupling Atrial Cardiac Muscle Cell To AV Node Cell Communication Lysine Transport L-histidine Import Across Plasma Membrane Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase Activity Odontogenesis Bundle Of His Cell To Purkinje Myocyte Communication Regulation Of Renin Secretion Into Blood Stream Gap Junction Channel Activity Involved In Cardiac Conduction Electrical Coupling Regulation Of AV Node Cell Action Potential L-ornithine Transmembrane Transport L-ornithine Transmembrane Transporter Activity Contact Inhibition Pancreas Morphogenesis Renal System Process Regulation Of Atrial Cardiac Muscle Cell Action Potential Gap Junction Channel Activity Involved In AV Node Cell-bundle Of His Cell Electrical Coupling SA Node Cell To Atrial Cardiac Muscle Cell Communication Negative Regulation Of Glomerular Filtration AV Node Cell To Bundle Of His Cell Communication By Electrical Coupling Ornithine Transport L-arginine Import Across Plasma Membrane Detection Of Cell Density Response To Inositol Coenzyme A Binding	Response To Zinc Ion Circadian Sleep/wake Cycle, Sleep Phospholamban Complex Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Zinc Ion Import Into Zymogen Granule Zinc Ion Import Into Mitochondrion Zinc Ion Import Into Secretory Vesicle Response To Unfolded Protein Regulation Of The Force Of Heart Contraction By Cardiac Conduction Calcium Ion-transporting ATPase Complex Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Cellular Homeostasis Negative Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Zinc Export Across Plasma Membrane Circadian Sleep/wake Cycle Process Vacuolar Transport Zinc Ion Import Into Lysosome ATPase Inhibitor Activity Zinc:proton Antiporter Activity Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Transporter Inhibitor Activity Regulation Of Relaxation Of Cardiac Muscle G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Cardiac Muscle Cell Membrane Potential Sleep Vacuolar Transmembrane Transport Response To Endoplasmic Reticulum Stress Muscle Organ Morphogenesis Secretory Vesicle Positive Regulation Of Growth Hormone Secretion Negative Regulation Of Growth Hormone Receptor Signaling Pathway Negative Regulation Of ATP-dependent Activity Locomotor Rhythm Endoplasmic Reticulum Membrane Negative Regulation Of Heart Rate Endosome Membrane Zinc Ion Import Into Organelle Negative Regulation Of Protein Localization To Cell Surface Regulation Of Growth Hormone Receptor Signaling Pathway Relaxation Of Cardiac Muscle Regulation Of Growth Hormone Secretion Negative Regulation Of Calcium Ion Import Positive Regulation Of Establishment Of Protein Localization Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Response To Metal Ion Regulation Of Relaxation Of Muscle Zymogen Granule Membrane Monoatomic Cation Transmembrane Transporter Activity Relaxation Of Muscle Circadian Behavior