SMUG1 and C10orf55

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SMUG1	C10orf55
Description		single-strand-selective monofunctional uracil-DNA glycosylase 1	chromosome 10 putative open reading frame 55
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytosol
	Molecular Function	Oxidized Pyrimidine Nucleobase Lesion DNA N-glycosylase Activity DNA Binding Uracil DNA N-glycosylase Activity Protein Binding Hydrolase Activity Single-strand Selective Uracil DNA N-glycosylase Activity DNA N-glycosylase Activity Identical Protein Binding	Protein Binding Identical Protein Binding
	Biological Process	DNA Repair Base-excision Repair DNA Damage Response Depyrimidination
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Displacement of DNA glycosylase by APEX1
Drugs
Diseases
GWAS		Coronary artery disease ( 32469254) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Crohn's disease ( 28067908) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Multiple sclerosis ( 24076602) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Systemic lupus erythematosus ( 28714469) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		37 interacting genes: C10orf55 CDC23 CRX CYSRT1 GLYCTK GPS2 HNRNPF INCA1 KCTD9 KLHDC7B KRTAP13-2 KRTAP15-1 KRTAP26-1 KRTAP6-2 KRTAP8-1 LMO2 MGAT5B NEK6 NOXA1 PEF1 PRKAB2 PROP1 PRR13 PRR35 RBPMS SKIL SMARCD1 SPAG8 TCF7L2 TEKT5 TFG TRAPPC6A TRIP13 VAC14 VENTX YPEL3 ZIC1	60 interacting genes: ATXN1 BOLA2 BOLA2B CRYBA2 DTX2 FAM168A FAM222B FNDC3B FOXH1 GCA HNF1B HNRNPF HSF4 INCA1 KRTAP15-1 KRTAP6-2 LENG8 LIMS3 LIMS4 MBLAC1 MGAT5B MYOZ3 NRF1 NXF1 OTX1 PFDN5 PITX1 PLEKHB1 PLSCR3 POGZ PRR20A PRR20B PRR20C PRR20D PRR20E RAMAC RBM24 RBM47 RBPMS RBPMS2 ROR2 SAXO4 SMUG1 SNRPB SOHLH1 SOX10 TBX6 TENT5B TENT5D TIAL1 TLE5 TP53BP1 UBAP2 UFSP1 VENTX VEZF1 WWOX YPEL3 ZC3H10 ZNF76
Entrez ID		23583	414236
HPRD ID		06376	16580
Ensembl ID		ENSG00000123415	ENSG00000222047
Uniprot IDs		A0A024RAZ8 A0A0S2Z526 D6RI04 Q53HV7
PDB IDs
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Regulation Of Mitotic Metaphase/anaphase Transition COPII Vesicle Coating Intermediate Filament Vesicle Coating Regulation Of Sister Chromatid Segregation Transcription Regulator Complex Regulation Of Chromosome Segregation	Nucleus Regulation Of RNA Metabolic Process Regulation Of RNA Splicing Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA CDS Binding MRNA Stabilization DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cytoplasmic Stress Granule Negative Regulation Of RNA Catabolic Process DNA-binding Transcription Factor Activity Positive Regulation Of Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of MRNA Metabolic Process [2Fe-2S] Cluster Assembly DNA Binding Regulation Of MRNA Splicing, Via Spliceosome Poly(A) RNA Polymerase Activity Iron-sulfur Cluster Assembly Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Binding Nuclear Inclusion Body Pre-mRNA Intronic Binding Regulation Of Primary Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of MRNA Metabolic Process Regulation Of Gene Expression MRNA 3'-UTR Binding Regulation Of MRNA Processing Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Embryonic Digestive Tract Morphogenesis Protein Binding RNA Binding
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