SMUG1

Gene Name		single-strand-selective monofunctional uracil-DNA glycosylase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Nucleolus Intracellular Membrane-bounded Organelle
	Molecular Function	Oxidized Pyrimidine Nucleobase Lesion DNA N-glycosylase Activity DNA Binding Uracil DNA N-glycosylase Activity Protein Binding Single-strand Selective Uracil DNA N-glycosylase Activity DNA N-glycosylase Activity
	Biological Process	DNA Catabolic Process, Endonucleolytic DNA Repair Base-excision Repair Base-excision Repair, AP Site Formation Depyrimidination
Pathways		Base Excision Repair Depyrimidination Resolution of AP sites via the multiple-nucleotide patch replacement pathway Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected pyrimidine Removal of DNA patch containing abasic residue Base-Excision Repair, AP Site Formation Resolution of AP sites via the single-nucleotide replacement pathway Base-free sugar-phosphate removal via the single-nucleotide replacement pathway Displacement of DNA glycosylase by APE1 Resolution of Abasic Sites (AP sites)
Drugs
Diseases
GWAS
Protein-protein Interactions		3 interactors: RBPMS TRIP13 VAC14
Entrez ID		23583
HPRD ID		06376
Ensembl ID		ENSG00000123415
Uniprot IDs		Q53HV7
PDB IDs
Enriched GO Terms of Interacting Partners?
Tagcloud ?		adjuvant anthracycline ape1 ar atm cdk1 chk2 cohorts consortium cyclophosphamide deregulation endocrine fen1 fluorouracil low lymphovascular methotrexate mib1 mitotic pkcs pleomorphism polbeta pr ps sporadic taxonomy topo2a worst xrcc1