POFUT1 and DLL1

Number of citations of the paper that reports this interaction (PubMedID 12036964)
0

Data Source:
HPRD (in vivo)

		POFUT1	DLL1
Description		protein O-fucosyltransferase 1	delta like canonical Notch ligand 1
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GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane	Extracellular Region Plasma Membrane Adherens Junction Membrane Apical Plasma Membrane Cytoplasmic Vesicle Membrane Raft Anchoring Junction
	Molecular Function	Transferase Activity Glycosyltransferase Activity Peptide-O-fucosyltransferase Activity	Notch Binding Calcium Ion Binding Protein Binding Tat Protein Binding Receptor Ligand Activity Scaffold Protein Binding
	Biological Process	Angiogenesis Somitogenesis Fucose Metabolic Process Protein Glycosylation Notch Signaling Pathway Nervous System Development Heart Development Regulation Of Notch Signaling Pathway Protein O-linked Glycosylation Via Fucose	Cell Fate Determination Somitogenesis Somite Specification Heart Looping Inhibition Of Neuroepithelial Cell Differentiation Marginal Zone B Cell Differentiation Type B Pancreatic Cell Development Cell Communication Notch Signaling Pathway Cell-cell Signaling Determination Of Left/right Symmetry Compartment Pattern Specification Regulation Of Blood Pressure Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Proximal/distal Pattern Formation Positive Regulation Of Gene Expression Astrocyte Development Regulation Of Somitogenesis Spinal Cord Development Cerebellar Molecular Layer Formation Cerebellar Purkinje Cell Layer Structural Organization Hemopoiesis Myeloid Cell Differentiation Cell Differentiation Regulation Of Cell Adhesion Neuron Differentiation Negative Regulation Of Epithelial Cell Differentiation Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Interleukin-10 Production Negative Regulation Of Glial Cell Apoptotic Process Organ Growth Regulation Of Growth Inner Ear Auditory Receptor Cell Differentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Epidermal Cell Differentiation Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of Neuron Differentiation Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Endocytosis Positive Regulation Of Transcription By RNA Polymerase II Lateral Inhibition Skeletal Muscle Tissue Growth Regulation Of Skeletal Muscle Tissue Growth Positive Regulation Of Skeletal Muscle Tissue Growth Neuron Fate Specification Inner Ear Development Regulation Of Neurogenesis Regulation Of Cell Division Retina Development In Camera-type Eye Retina Morphogenesis In Camera-type Eye Neuroepithelial Cell Differentiation Notch Signaling Pathway Involved In Arterial Endothelial Cell Fate Commitment Left/right Axis Specification Nephron Development Proximal Tubule Development Loop Of Henle Development Clathrin-dependent Endocytosis Energy Homeostasis Endothelial Tip Cell Fate Specification Neuronal Stem Cell Population Maintenance Skin Epidermis Development Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Sprouting Angiogenesis Negative Regulation Of Cardiac Muscle Cell Differentiation
Pathways		Pre-NOTCH Processing in the Endoplasmic Reticulum	Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus MECP2 regulates transcription of neuronal ligands Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin Formation of paraxial mesoderm Somitogenesis Nephron development
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Chronic obstructive pulmonary disease ( 28166215) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Inflammatory bowel disease ( 28067908)	Interferon alpha levels in systemic lupus erythematosus ( 25338677) Intraocular pressure ( 29785010) Plasma anti-thyroglobulin levels ( 29678681) Type 1 diabetes ( 21980299)
Interacting Genes		4 interacting genes: AKT2 DLL1 JAG1 NOTCH1	10 interacting genes: ADAM10 CCN3 CNKSR3 MAGI2 MFNG NOTCH1 NOTCH2 NOTCH3 POFUT1 PSEN1
Entrez ID		23509	28514
HPRD ID		06319	05957
Ensembl ID		ENSG00000101346	ENSG00000198719
Uniprot IDs		Q9H488	A0A384P5C6 O00548
PDB IDs		5UX6 5UXH	4XBM
Enriched GO Terms of Interacting Partners?		Neuron Differentiation Inhibition Of Neuroepithelial Cell Differentiation Regulation Of Timing Of Cell Differentiation Regulation Of Development, Heterochronic Left/right Axis Specification Inner Ear Auditory Receptor Cell Differentiation Hair Cell Differentiation Inner Ear Receptor Cell Differentiation Epidermal Cell Differentiation Nephron Tubule Development Renal Tubule Development Neuronal Stem Cell Population Maintenance Notch Binding Mechanoreceptor Differentiation Tube Morphogenesis Stem Cell Population Maintenance Maintenance Of Cell Number Neuroepithelial Cell Differentiation Distal Tubule Development Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Negative Regulation Of Inner Ear Receptor Cell Differentiation Compartment Pattern Specification Positive Regulation Of Notch Signaling Pathway Loop Of Henle Development Negative Regulation Of Epithelial Cell Differentiation Epithelial Cell Differentiation Regulation Of Somitogenesis Regulation Of Neuron Differentiation Heart Looping Embryonic Heart Tube Morphogenesis Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Kidney Epithelium Development Negative Regulation Of Neuron Differentiation Epithelium Development Regulation Of Inner Ear Auditory Receptor Cell Differentiation Axis Specification Regulation Of Embryonic Development Nephron Development Determination Of Bilateral Symmetry Determination Of Left/right Symmetry Regulation Of Notch Signaling Pathway Negative Regulation Of Epidermal Cell Differentiation Regulation Of Cell Differentiation Blood Vessel Morphogenesis Notch Signaling Pathway Pulmonary Valve Morphogenesis Epithelial Tube Morphogenesis Morphogenesis Of An Epithelium Cell Differentiation Neuroendocrine Cell Differentiation	Notch Signaling Pathway Regulation Of Notch Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Golgi Membrane Angiogenesis Protein Catabolic Process At Postsynapse Cellular Response To Tumor Cell Regulation Of Signal Transduction Pattern Specification Process Positive Regulation Of Notch Signaling Pathway Epithelial Cell Proliferation Regulation Of Cell Communication Regulation Of Signaling Atrioventricular Node Development Glomerular Capillary Formation Heart Looping Embryonic Heart Tube Morphogenesis Forebrain Development Marginal Zone B Cell Differentiation Cell Surface Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Embryonic Limb Morphogenesis Podocyte Development Tube Morphogenesis Cell Surface Receptor Signaling Pathway Limb Morphogenesis Left/right Axis Specification Epithelial Tube Morphogenesis Amyloid Precursor Protein Catabolic Process Lymphocyte Activation Involved In Immune Response Pulmonary Valve Morphogenesis Positive Regulation Of Ras Protein Signal Transduction Negative Regulation Of Myotube Differentiation Myeloid Leukocyte Activation Epithelial Cell Development Morphogenesis Of An Epithelial Sheet Myeloid Dendritic Cell Differentiation Nephron Tubule Development Positive Regulation Of Smooth Muscle Cell Differentiation Membrane Protein Ectodomain Proteolysis Notch Binding Amyloid Precursor Protein Metabolic Process Leukocyte Activation Involved In Immune Response Regulation Of Muscle Cell Differentiation Cell Activation Involved In Immune Response Renal Tubule Development Anterior/posterior Pattern Specification Myeloid Dendritic Cell Activation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Mature B Cell Differentiation Involved In Immune Response
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