SIRT5 and LSS

		SIRT5	LSS
Description		sirtuin 5	lanosterol synthase
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Cytosol	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Membrane
	Molecular Function	NAD+ Poly-ADP-ribosyltransferase Activity Zinc Ion Binding Transferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Histone Deacetylase Activity, NAD-dependent NAD-dependent Protein Lysine Deacetylase Activity Protein-malonyllysine Demalonylase Activity Protein-succinyllysine Desuccinylase Activity Metal Ion Binding Protein-glutaryllysine Deglutarylase Activity NAD+ Binding NAD+-protein Mono-ADP-ribosyltransferase Activity	Lanosterol Synthase Activity Protein Binding Isomerase Activity Intramolecular Transferase Activity
	Biological Process	Response To Ischemia Protein Deacetylation Mitochondrion Organization Regulation Of Ketone Biosynthetic Process Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Response To Nutrient Levels Protein Demalonylation Peptidyl-lysine Demalonylation Protein Desuccinylation Peptidyl-lysine Desuccinylation Protein Deglutarylation Negative Regulation Of Reactive Oxygen Species Metabolic Process	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Triterpenoid Biosynthetic Process Regulation Of Protein Stability
Pathways		Transcriptional activation of mitochondrial biogenesis	Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)
Drugs		Adenosine-5-Diphosphoribose Nicotinamide 2'-O-Acetyl Adenosine-5-Diphosphoribose Suramin Cambinol	R048-8071 Lanosterol
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Perceived intensity of sweet substances ( 31005972)	Glutathione peroxidase in non-alcoholic fatty liver disease x mastiha supplementation interaction ( 34025683) White blood cell count ( 27863252)
Interacting Genes		4 interacting genes: APP TP53 TRIM21 USP7	9 interacting genes: AQP6 CIB1 GPR35 NR4A1 SLC10A1 SLC10A6 TMEM167B TMEM86B YIF1A
Entrez ID		23408	4047
HPRD ID		06838	02945
Ensembl ID		ENSG00000124523	ENSG00000160285
Uniprot IDs		A0A7P0T9N1 A0A7P0Z4N6 Q9NXA8	B2R694 P48449
PDB IDs		2B4Y 2NYR 3RIG 3RIY 4F4U 4F56 4G1C 4HDA 5BWL 5XHS 6ACE 6ACL 6ACO 6ACP 6EQS 6LJK 6LJM 6LJN 7X3P 8GBL 8GBN	1W6J 1W6K
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Stability Molecular Function Activator Activity Positive Regulation Of Gene Expression, Epigenetic Amyloid-beta Complex Growth Cone Lamellipodium Epigenetic Regulation Of Gene Expression Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Regulation Of Carbohydrate Catabolic Process Regulation Of MiRNA Transcription Amylin Binding Regulation Of Purine Nucleotide Metabolic Process Regulation Of Proteolysis Positive Regulation Of Toll Signaling Pathway Regulation Of Small Molecule Metabolic Process Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Reactive Oxygen Species Metabolic Process Triterpenoid Biosynthetic Process Lanosterol Synthase Activity Regulation Of Autophagy P53 Binding Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Nucleotide-excision Repair Acetylcholine Receptor Activator Activity Protein-folding Chaperone Binding PTB Domain Binding Chromatin Remodeling Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Catabolic Process Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of MiRNA Metabolic Process Regulation Of Biological Quality Endosome To Plasma Membrane Transport Vesicle Protein Tetramerization Regulation Of Protein Metabolic Process Positive Regulation Of Endothelin Production Regulation Of Reactive Oxygen Species Metabolic Process Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Generation Of Precursor Metabolites And Energy Intramolecular Transferase Activity Autophagosome Organization Negative Regulation Of Protein Metabolic Process Autophagosome Assembly	Bile Acid:sodium Symporter Activity Nitrate Transmembrane Transporter Activity Bile Acid And Bile Salt Transport Cytoplasmic Side Of Nuclear Pore Positive Regulation Of Male Germ Cell Proliferation Peptidyl-lysine Demalonylation Protein Demalonylation Protein Desuccinylation Peptidyl-lysine Desuccinylation Protein-malonyllysine Demalonylase Activity D-lysine 5,6-aminomutase Activity Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport Response To Ischemia PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Chemokine-mediated Signaling Pathway Protein-glutaryllysine Deglutarylase Activity Protein-succinyllysine Desuccinylase Activity Protein Deglutarylation Ether Hydrolase Activity Alkenylglycerophosphocholine Hydrolase Activity Nuclear Pore Symporter Activity Endomitotic Cell Cycle Calcium-dependent Protein Kinase Inhibitor Activity Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Import Into Nucleus Detection Of Lipopolysaccharide Cellular Response To Corticotropin-releasing Hormone Stimulus Protein Import Into Nucleus Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane MRNA Transport Regulation Of Nucleocytoplasmic Transport Regulation Of Male Germ Cell Proliferation Histone Deacetylase Activity, NAD-dependent Monocarboxylic Acid Transport
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