SIRT5

Gene Name		sirtuin 5
Image
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Intermembrane Space Mitochondrial Matrix Cytosol
	Molecular Function	NAD+ ADP-ribosyltransferase Activity Zinc Ion Binding Protein-malonyllysine Demalonylase Activity Protein-succinyllysine Desuccinylase Activity NAD+ Binding
	Biological Process	Chromatin Silencing Protein ADP-ribosylation Protein Deacetylation Peptidyl-lysine Demalonylation Protein Desuccinylation Peptidyl-lysine Desuccinylation Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
Drugs
Diseases
GWAS
Protein-protein Interactions		1 interactors: APP
Entrez ID		23408
HPRD ID		06838
Ensembl ID		ENSG00000124523
Uniprot IDs		Q9NXA8
PDB IDs		2B4Y 2NYR 3RIG 3RIY 4F4U 4F56 4G1C 4HDA
Enriched GO Terms of Interacting Partners?		Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Neuron Remodeling Cellular Copper Ion Homeostasis Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis Neuron Recognition RNA Polyadenylation Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Axon Cargo Transport Mating Neuromuscular Junction Development Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Neuron Apoptotic Process Regulation Of Protein Tyrosine Kinase Activity Visual Learning Glutamate Receptor Signaling Pathway Visual Behavior Neuron Death Platelet Degranulation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuromuscular Process Controlling Balance Synapse Assembly MRNA 3'-end Processing Regulation Of ERBB Signaling Pathway Associative Learning Developmental Cell Growth Regulation Of Synapse Structure Or Activity Feeding Behavior Regulation Of Multicellular Organism Growth RNA 3'-end Processing Cholesterol Metabolic Process Adult Locomotory Behavior Positive Regulation Of Mitotic Cell Cycle Regulation Of Receptor Activity Cell Recognition
Tagcloud ?		acetylation bodies catalytic conjugation deacetylases deacetylation defective ectopic exclusive h2o2 hela hydrogen k487 k487r k490 knockdown mutually nbs peroxide pml promyelocytic reduces rescues restore sirt1 sumo1 sumoylation translational ubiquitination