ARHGEF18 and ZMYND11

Number of citations of the paper that reports this interaction (PubMedID 35044719)
104

Data Source:
BioGRID (unspecified method)

		ARHGEF18	ZMYND11
Description		Rho/Rac guanine nucleotide exchange factor 18	zinc finger MYND-type containing 11
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Apical Plasma Membrane Cell Junction Apical Part Of Cell Extracellular Exosome	Nucleus Nucleoplasm Chromosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding	DNA Binding Double-stranded DNA Binding Transcription Corepressor Activity Protein Binding Zinc Ion Binding Metal Ion Binding Histone H3K36me3 Reader Activity
	Biological Process	Small GTPase-mediated Signal Transduction Regulation Of Cell Shape Actin Cytoskeleton Organization Regulation Of Rho Protein Signal Transduction Negative Regulation Of Stress Fiber Assembly Protein Localization To Cell-cell Junction	Chromatin Organization Regulation Of Signal Transduction Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of DNA-templated Transcription Negative Regulation Of JNK Cascade Defense Response To Virus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		NRAGE signals death through JNK TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) G alpha (12/13) signalling events RHOA GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS			Malaria ( 31844061)
Interacting Genes		4 interacting genes: GNB1 HRAS RHOA ZMYND11	26 interacting genes: ARHGEF18 BMPR1A DYNLL1 E2F6 EMSY ETS2 EZH1 EZH2 H3-3A H3-4 H4C1 HDAC1 HOXD4 LTBR MAGEC2 MYB NCOR1 PDLIM7 SMAD2 SMAD3 SMARCA4 SRPK1 TAB1 TRAF3 TRAF6 ZHX1
Entrez ID		23370	10771
HPRD ID		12479	09830
Ensembl ID		ENSG00000104880	ENSG00000015171
Uniprot IDs		A0A087WZG4 A0A3B3IPE9 Q6ZSZ5	A0A0D9SGD6 A0A994J4C0 A0A994J4I8 A0A994J6Y5 B7Z2J6 E7ENI9 Q15326 Q5BJG6 Q5UGI2
PDB IDs			4NS5 5HDA
Enriched GO Terms of Interacting Partners?		Small GTPase-mediated Signal Transduction GTPase Activity G Protein Activity Ras Protein Signal Transduction Neuron Apoptotic Process Negative Regulation Of Apoptotic Process Aortic Valve Formation Intracellular Signaling Cassette Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Vascular Associated Smooth Muscle Contraction Endothelial Tube Lumen Extension Mitotic Cleavage Furrow Formation Skeletal Muscle Satellite Cell Migration Regulation Of JNK Cascade GTPase Complex Negative Regulation Of Programmed Cell Death Negative Regulation Of Neuron Apoptotic Process Beta Selection Phospholipase C Activator Activity Bone Trabecula Morphogenesis Apolipoprotein A-I-mediated Signaling Pathway Regulation Of Neuron Apoptotic Process Positive Regulation Of Lipase Activity Positive Regulation Of Podosome Assembly Regulation Of Actin Cytoskeleton Organization Cleavage Furrow Formation Chemotaxis Regulation Of Apoptotic Process Regulation Of Systemic Arterial Blood Pressure By Endothelin Response To External Biotic Stimulus Regulation Of Vascular Associated Smooth Muscle Contraction Negative Regulation Of Cell Size Regulation Of Canonical NF-kappaB Signal Transduction Apical Junction Assembly Regulation Of Programmed Cell Death Ossification Involved In Bone Maturation Negative Regulation Of Motor Neuron Apoptotic Process Locomotion Negative Regulation Of Cellular Respiration GTP Binding Roundabout Signaling Pathway Negative Regulation Of Oxidative Phosphorylation Forebrain Radial Glial Cell Differentiation Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Oncogene-induced Cell Senescence T-helper 1 Type Immune Response Histone H3K36me3 Reader Activity Endothelial Tube Morphogenesis Regulation Of Actin Filament-based Process	Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II DNA Binding Chromatin Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Transcription Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Endoderm Development Regulation Of MiRNA Metabolic Process Chromatin Organization Negative Regulation Of Metabolic Process Subtelomeric Heterochromatin Formation Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Positive Regulation Of MiRNA Transcription Constitutive Heterochromatin Formation Chordate Embryonic Development Heterochromatin Formation Negative Regulation Of Androgen Receptor Signaling Pathway Cell Differentiation Embryo Development Ending In Birth Or Egg Hatching Positive Regulation Of MiRNA Metabolic Process Multicellular Organism Development Positive Regulation Of Transforming Growth Factor Beta Production RNA Polymerase II Core Promoter Sequence-specific DNA Binding Cellular Developmental Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Cell Differentiation Histone H3K27 Trimethyltransferase Activity Paraxial Mesoderm Morphogenesis Chromosome, Telomeric Region RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Animal Organ Morphogenesis Positive Regulation Of Macromolecule Metabolic Process
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