ARHGEF18

Gene Name		Rho/Rac guanine nucleotide exchange factor (GEF) 18
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Cell Junction Apical Part Of Cell Extracellular Vesicular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity
	Biological Process	Transforming Growth Factor Beta Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Regulation Of Cell Shape Actin Cytoskeleton Organization Positive Regulation Of Rho GTPase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway
Pathways		Loss of Function of TGFBR2 in Cancer Signaling by GPCR TGFBR2 MSI Frameshift Mutants in Cancer Signalling by NGF TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer Cell death signalling via NRAGE, NRIF and NADE TGFBR2 Kinase Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer p75 NTR receptor-mediated signalling TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Rho GTPase cycle GPCR downstream signaling Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer NRAGE signals death through JNK Signaling by Rho GTPases G alpha (12/13) signalling events SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Protein-protein Interactions		2 interactors: GNB1 RHOA
Entrez ID		23370
HPRD ID		12479
Ensembl ID		ENSG00000104880
Uniprot IDs		Q6ZSZ5
PDB IDs
Enriched GO Terms of Interacting Partners?		Platelet Activation Ras Protein Signal Transduction Skeletal Muscle Satellite Cell Migration Blood Coagulation Hemostasis Apolipoprotein A-I-mediated Signaling Pathway Cleavage Furrow Formation Cardiac Muscle Cell Apoptotic Process Muscle Cell Apoptotic Process Regulation Of Body Fluid Levels Wound Healing Small GTPase Mediated Signal Transduction Cell Activation Response To Wounding Cellular Response To Prostaglandin E Stimulus G-protein Coupled Acetylcholine Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Ossification Involved In Bone Maturation Bone Maturation Response To Prostaglandin E Negative Chemotaxis Cellular Response To Prostaglandin Stimulus Mitotic Spindle Assembly Positive Regulation Of NF-kappaB Import Into Nucleus Regulation Of Osteoblast Proliferation Regulation Of Rhodopsin Mediated Signaling Pathway Cellular Response To Catecholamine Stimulus Rhodopsin Mediated Signaling Pathway Dopamine Receptor Signaling Pathway Substantia Nigra Development Wound Healing, Spreading Of Cells Cellular Response To Glucagon Stimulus Positive Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Cytokinesis Regulation Of NF-kappaB Import Into Nucleus Mitotic Spindle Organization Positive Regulation Of Stress Fiber Assembly Cellular Response To Fatty Acid Positive Regulation Of Actin Filament Bundle Assembly Trabecula Morphogenesis Neural Nucleus Development Response To Glucagon Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Cytokinesis Rho Protein Signal Transduction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Sensory Perception Of Taste Morphogenesis Of An Epithelial Sheet Negative Regulation Of Axonogenesis Regulation Of Stress Fiber Assembly
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