ARHGEF18

Description		Rho/Rac guanine nucleotide exchange factor 18
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Apical Plasma Membrane Cell Junction Apical Part Of Cell Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Small GTPase-mediated Signal Transduction Regulation Of Cell Shape Actin Cytoskeleton Organization Regulation Of Rho Protein Signal Transduction Negative Regulation Of Stress Fiber Assembly Protein Localization To Cell-cell Junction
Pathways		NRAGE signals death through JNK TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) G alpha (12/13) signalling events RHOA GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS
Interacting Genes		4 interacting genes: GNB1 HRAS RHOA ZMYND11
Entrez ID		23370
HPRD ID		12479
Ensembl ID		ENSG00000104880
Uniprot IDs		A0A087WZG4 A0A3B3IPE9 Q6ZSZ5
PDB IDs
Enriched GO Terms of Interacting Partners?		Small GTPase-mediated Signal Transduction GTPase Activity G Protein Activity Ras Protein Signal Transduction Neuron Apoptotic Process Negative Regulation Of Apoptotic Process Aortic Valve Formation Intracellular Signaling Cassette Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Vascular Associated Smooth Muscle Contraction Endothelial Tube Lumen Extension Mitotic Cleavage Furrow Formation Skeletal Muscle Satellite Cell Migration Regulation Of JNK Cascade GTPase Complex Negative Regulation Of Programmed Cell Death Negative Regulation Of Neuron Apoptotic Process Beta Selection Phospholipase C Activator Activity Bone Trabecula Morphogenesis Apolipoprotein A-I-mediated Signaling Pathway Regulation Of Neuron Apoptotic Process Positive Regulation Of Lipase Activity Positive Regulation Of Podosome Assembly Regulation Of Actin Cytoskeleton Organization Cleavage Furrow Formation Chemotaxis Regulation Of Apoptotic Process Regulation Of Systemic Arterial Blood Pressure By Endothelin Response To External Biotic Stimulus Regulation Of Vascular Associated Smooth Muscle Contraction Negative Regulation Of Cell Size Regulation Of Canonical NF-kappaB Signal Transduction Apical Junction Assembly Regulation Of Programmed Cell Death Ossification Involved In Bone Maturation Negative Regulation Of Motor Neuron Apoptotic Process Locomotion Negative Regulation Of Cellular Respiration GTP Binding Roundabout Signaling Pathway Negative Regulation Of Oxidative Phosphorylation Forebrain Radial Glial Cell Differentiation Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Oncogene-induced Cell Senescence T-helper 1 Type Immune Response Histone H3K36me3 Reader Activity Endothelial Tube Morphogenesis Regulation Of Actin Filament-based Process
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