CLASP1 and PRKRA

		CLASP1	PRKRA
Description		cytoplasmic linker associated protein 1	protein activator of interferon induced protein kinase EIF2AK2
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Chromosome Cytoplasm Golgi Apparatus Centrosome Microtubule Organizing Center Spindle Kinetochore Microtubule Cytosol Cytoskeleton Microtubule Spindle Microtubule Cytoplasmic Microtubule Focal Adhesion Cell Cortex Membrane Cortical Microtubule Cytoskeleton Centrosomal Corona Microtubule Plus-end Basal Cortex Mitotic Spindle	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane RISC Complex Perinuclear Region Of Cytoplasm RISC-loading Complex
	Molecular Function	Dystroglycan Binding Protein Binding Microtubule Binding Tubulin Binding Kinetochore Binding Microtubule Plus-end Binding	RNA Binding Double-stranded RNA Binding Protein Binding Enzyme Activator Activity Enzyme Binding Protein Kinase Activator Activity SiRNA Binding Identical Protein Binding Protein Homodimerization Activity Pre-miRNA Binding
	Biological Process	Microtubule Cytoskeleton Organization Microtubule Bundle Formation Vesicle Targeting Microtubule Nucleation Negative Regulation Of Microtubule Depolymerization Golgi Organization Mitotic Spindle Organization Establishment Or Maintenance Of Cell Polarity Exit From Mitosis Regulation Of Gastrulation Positive Regulation Of Epithelial Cell Migration Regulation Of Epithelial To Mesenchymal Transition Establishment Of Cell Polarity Astral Microtubule Organization Microtubule Organizing Center Organization Negative Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Microtubule Polymerization Microtubule Anchoring Establishment Of Mitotic Spindle Localization Positive Regulation Of Exocytosis Establishment Of Spindle Orientation Cell Division Negative Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Basement Membrane Organization Positive Regulation Of Extracellular Matrix Disassembly Mitotic Spindle Assembly Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Basement Membrane Assembly Involved In Embryonic Body Morphogenesis	Immune Response Negative Regulation Of Cell Population Proliferation Response To Virus SiRNA Processing Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Processing Cellular Response To Oxidative Stress MiRNA Processing Outer Ear Morphogenesis Middle Ear Morphogenesis Ear Development Skeletal System Morphogenesis Protein Stabilization Regulation Of Regulatory NcRNA Processing RISC Complex Assembly Antiviral Innate Immune Response Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Role of ABL in ROBO-SLIT signaling Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation	MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis PKR-mediated signaling
Drugs		Fostamatinib
Diseases			Primary torsion dystonia (PTD)
GWAS		Chloride levels ( 29403010) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) HDL cholesterol x physical activity interaction (1df test) ( 30670697) HDL cholesterol x physical activity interaction (2df test) ( 30670697) Low density lipoprotein cholesterol levels ( 32154731) Metabolite levels ( 23823483) Potassium levels ( 29403010) Triglyceride levels ( 32154731)	Inflammatory skin disease ( 25574825) Multiple sclerosis (OCB status) ( 23472185) Rapid functional decline in sporadic amyotrophic lateral sclerosis ( 26746183)
Interacting Genes		12 interacting genes: CEBPA CKAP5 EIF4ENIF1 JAKMIP2 MAP4 MAPRE1 MAPRE3 MARK3 MTNR1A MTNR1B SRPK2 YWHAG	29 interacting genes: ADARB1 AGO2 CEBPZ CEP126 COPS6 DICER1 EHHADH EIF2AK2 GDF9 H19 LNX1 LYAR NEIL3 NKRF PIAS2 PNPT1 POLR2G RABEPK RB1 RBPMS SETDB1 SHC1 SNX5 TARBP2 TIRAP TP53 ZFP28 ZMAT3 ZNF746
Entrez ID		23332	8575
HPRD ID		09322	04573
Ensembl ID		ENSG00000074054	ENSG00000180228
Uniprot IDs		A0A8V8TLP7 A0A8V8TRF6 Q7Z460	A0A7I2V2I8 A0A7I2V5H3 B4DJC7 O75569
PDB IDs		4K92 6MQ5 6MQ7	2DIX
Enriched GO Terms of Interacting Partners?		Microtubule Binding Microtubule Polymerization Microtubule Plus-end Microtubule Plus-end Binding Mitotic Spindle Astral Microtubule End Microtubule Polymerization Or Depolymerization Melatonin Receptor Activity Spindle Organization Microtubule Cytoskeleton Organization Regulation Of Microtubule Polymerization Protein Polymerization Microtubule Cytoskeleton Microtubule Organizing Center Protein Localization To Microtubule Kinase Binding Regulation Of Microtubule Polymerization Or Depolymerization Microtubule Cytoskeleton Organization Involved In Mitosis Protein Serine/threonine Kinase Binding Organelle Organization Spindle Midzone Microtubule-based Process Regulation Of Microtubule Cytoskeleton Organization Cell Division Positive Regulation Of Microtubule Polymerization RNA Binding Establishment Of Spindle Orientation Cytoskeleton Organization Protein Localization To Cytoskeleton RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Microtubule Plus End Polymerase Protein Localization To Astral Microtubule Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Establishment Of Spindle Localization Cellular Component Assembly Cytoplasmic Microtubule Regulation Of Microtubule-based Process Tubulin Binding Spindle Localization Protein Localization To Organelle Membraneless Organelle Assembly Response To Vitamin B2 C/EBP Complex Negative Regulation Of Non-motile Cilium Assembly Microtubule Stabilizing Activity Ciliary Basal Body Protein Localization To Mitotic Spindle Protein Localization To Spindle Microtubule Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Protein-containing Complex Assembly	Double-stranded RNA Binding RISC-loading Complex SiRNA Processing RISC Complex Assembly SiRNA Binding Negative Regulation Of Macromolecule Metabolic Process Pre-miRNA Processing Positive Regulation Of RNA Metabolic Process Negative Regulation Of Glial Cell Proliferation Negative Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Global Gene Silencing By MRNA Cleavage Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleic Acid Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process RNA Binding Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process RNA Endonuclease Activity Producing 5'-phosphomonoesters, Hydrolytic Mechanism Regulation Of Macromolecule Metabolic Process Glial Cell Apoptotic Process Positive Regulation Of Macromolecule Metabolic Process MiRNA Processing Regulation Of Gene Expression MiRNA Binding Negative Regulation Of Gene Expression Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gliogenesis Regulation Of Glial Cell Proliferation Identical Protein Binding Pre-miRNA Binding Positive Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Post-transcriptional Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Nucleoplasm Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Receptor Tyrosine Kinase Binding Negative Regulation Of Catalytic Activity Negative Regulation Of Phosphate Metabolic Process Regulation Of MiRNA Processing Regulation Of Regulatory NcRNA Processing
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