USP22 and AASDHPPT

Number of citations of the paper that reports this interaction (PMID 19615732)
279

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		USP22	AASDHPPT
Gene Name		ubiquitin specific peptidase 22	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	SAGA Complex SAGA-type Complex	Cytosol Extracellular Vesicular Exosome
	Molecular Function	Transcription Coactivator Activity Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding H4 Histone Acetyltransferase Activity Enzyme Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity	Magnesium Ion Binding Protein Binding Holo-[acyl-carrier-protein] Synthase Activity
	Biological Process	Chromatin Organization Transcription, DNA-templated Cell Cycle Embryo Development Histone Ubiquitination Histone Deubiquitination Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Histone H4 Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle Regulation Of Proteasomal Protein Catabolic Process	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Macromolecule Biosynthetic Process Pantothenate Metabolic Process Small Molecule Metabolic Process
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones	Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Vitamin B5 (pantothenate) metabolism Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Metabolism of water-soluble vitamins and cofactors Defective MUT causes methylmalonic aciduria mut type Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in cobalamin (B12) metabolism Defects in vitamin and cofactor metabolism
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: AASDHPPT HEXA HIST2H2AC HIST2H2BE MRPL10 MRPL44 PSME1 SCFD1 UBC	4 interactors: MDFI SIAH1 TRAF2 USP22
Entrez ID		23326	60496
HPRD ID		19411	09675
Ensembl ID		ENSG00000124422	ENSG00000149313
Uniprot IDs		Q9UPT9	Q9NRN7
PDB IDs			2BYD 2C43 2CG5
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Mitochondrial Translational Elongation Mitochondrial Translational Initiation Mitochondrial Translational Termination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Ligase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Mitochondrial Translation Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Regulation Of Cell Cycle Arrest Mitotic DNA Integrity Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Ubiquitination Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Signal Transduction By P53 Class Mediator Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Autophagic Vacuole Assembly Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Ubiquitination Regulation Of Cell Cycle G1/S Phase Transition Translational Termination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cellular Protein Catabolic Process DNA Damage Checkpoint Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Positive Regulation Of Wnt Signaling Pathway G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Protein Polyubiquitination Translational Elongation Cellular Protein Complex Disassembly	Positive Regulation Of JUN Kinase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of JUN Kinase Activity Protein Catabolic Process Positive Regulation Of JNK Cascade Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of JNK Cascade Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of MAP Kinase Activity Positive Regulation Of Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Binding Proteasomal Protein Catabolic Process Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of MAP Kinase Activity Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Intracellular Signal Transduction Catabolic Process Positive Regulation Of Protein Homodimerization Activity Cellular Response To Nitric Oxide Regulation Of Gene Expression Positive Regulation Of MAPK Cascade Regulation Of Immunoglobulin Secretion Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Response To Nitric Oxide Positive Regulation Of Kinase Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Trophoblast Giant Cell Differentiation Regulation Of Protein Metabolic Process Protein Homotrimerization Positive Regulation Of T Cell Cytokine Production Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Transferase Activity Histone Deubiquitination Regulation Of Protein Homodimerization Activity Cellular Protein Catabolic Process Cellular Response To Reactive Nitrogen Species Positive Regulation Of Apoptotic Process Cytoplasmic Sequestering Of Transcription Factor Dorsal/ventral Axis Specification Positive Regulation Of Programmed Cell Death Regulation Of MAPK Cascade Positive Regulation Of Cell Death
Tagcloud ?		activates additionally along arrests clinicopathologic curbs downregulates g0 g1 great immunoprecipitation inhibits interacts mdmx nsclc oncology overexpressed phases promotes protease represent reverses shows shrna silencing tumorigenesis ubiquitin upregulation xenograft
Tagcloud (Difference) ?		activates additionally along arrests clinicopathologic curbs downregulates g0 g1 great immunoprecipitation inhibits interacts mdmx nsclc oncology overexpressed phases promotes protease represent reverses shows shrna silencing tumorigenesis ubiquitin upregulation xenograft
Tagcloud (Intersection) ?