AASDHPPT

Gene Name		aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
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Gene Ontology Annotations	Cellular Component	Cytosol Extracellular Vesicular Exosome
	Molecular Function	Magnesium Ion Binding Protein Binding Holo-[acyl-carrier-protein] Synthase Activity
	Biological Process	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Macromolecule Biosynthetic Process Pantothenate Metabolic Process Small Molecule Metabolic Process
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Vitamin B5 (pantothenate) metabolism Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Metabolism of water-soluble vitamins and cofactors Defective MUT causes methylmalonic aciduria mut type Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in cobalamin (B12) metabolism Defects in vitamin and cofactor metabolism
Drugs
Diseases
GWAS
Protein-protein Interactions		4 interactors: MDFI SIAH1 TRAF2 USP22
Entrez ID		60496
HPRD ID		09675
Ensembl ID		ENSG00000149313
Uniprot IDs		Q9NRN7
PDB IDs		2BYD 2C43 2CG5
Enriched GO Terms of Interacting Partners?		Positive Regulation Of JUN Kinase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of JUN Kinase Activity Protein Catabolic Process Positive Regulation Of JNK Cascade Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of JNK Cascade Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of MAP Kinase Activity Positive Regulation Of Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Binding Proteasomal Protein Catabolic Process Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of MAP Kinase Activity Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Intracellular Signal Transduction Catabolic Process Positive Regulation Of Protein Homodimerization Activity Cellular Response To Nitric Oxide Regulation Of Gene Expression Positive Regulation Of MAPK Cascade Regulation Of Immunoglobulin Secretion Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Response To Nitric Oxide Positive Regulation Of Kinase Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Trophoblast Giant Cell Differentiation Regulation Of Protein Metabolic Process Protein Homotrimerization Positive Regulation Of T Cell Cytokine Production Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Transferase Activity Histone Deubiquitination Regulation Of Protein Homodimerization Activity Cellular Protein Catabolic Process Cellular Response To Reactive Nitrogen Species Positive Regulation Of Apoptotic Process Cytoplasmic Sequestering Of Transcription Factor Dorsal/ventral Axis Specification Positive Regulation Of Programmed Cell Death Regulation Of MAPK Cascade Positive Regulation Of Cell Death
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