FMO3 and SERPINC1

		FMO3	SERPINC1
Description		flavin containing dimethylaniline monoxygenase 3	serpin family C member 1
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Monooxygenase Activity N,N-dimethylaniline Monooxygenase Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Trimethylamine Monooxygenase Activity Albendazole Monooxygenase Activity Hypotaurine Monooxygenase Activity Flavin Adenine Dinucleotide Binding NADP Binding	Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Heparin Binding Peptidase Inhibitor Activity Identical Protein Binding
	Biological Process	Taurine Biosynthetic Process	Blood Coagulation Hemostasis Regulation Of Blood Coagulation
Pathways		FMO oxidises nucleophiles Defective FMO3 causes TMAU	Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs			Ardeparin Fondaparinux Heparin Enoxaparin N-Formylmethionine SR-123781A Sulodexide Danaparoid Dalteparin Tinzaparin Nadroparin Copper Protamine sulfate Bemiparin Antithrombin III human
Diseases			Inherited thrombophilia
GWAS		Lentiform nucleus volume ( 22903471) Serum metabolite levels ( 33031748)	Experiencing mood swings ( 29500382) Heel bone mineral density ( 30598549)
Interacting Genes		4 interacting genes: CLEC10A CREB3 SACM1L SGSM3	7 interacting genes: F2 HSP90AA1 KLK1 KLK2 KLK6 PLG SDC2
Entrez ID		2328	462
HPRD ID		00633	00122
Ensembl ID		ENSG00000007933	ENSG00000117601
Uniprot IDs		A0A024R8Z4 B7Z3M2 B7Z543 P31513 Q53FW5	P01008
PDB IDs			1ANT 1ATH 1AZX 1BR8 1DZG 1DZH 1E03 1E04 1E05 1JVQ 1LK6 1NQ9 1OYH 1R1L 1SR5 1T1F 1TB6 2ANT 2B4X 2B5T 2BEH 2GD4 2HIJ 2ZNH 3EVJ 3KCG 4EB1
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Deacetylase Activity	Serine-type Peptidase Activity Serine-type Endopeptidase Activity Protein Processing Peptidase Activity Negative Regulation Of Fibrinolysis Extracellular Exosome Extracellular Space Secretory Granule Regulation Of Fibrinolysis Fibrinolysis Protein Maturation MHC Class II Protein Complex Binding Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Regulation Of Biological Quality Biological Process Involved In Interaction With Symbiont Zymogen Activation Protein Metabolic Process Negative Regulation Of Coagulation Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Extracellular Region Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Albendazole Monooxygenase Activity CTP Binding DATP Binding Regulation Of Systemic Arterial Blood Pressure Tissue Regeneration Hydrolase Activity Cellular Homeostasis Protein Transport Into Plasma Membrane Raft Positive Regulation Of Wound Healing Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Endoplasmic Reticulum Lumen Trimethylamine Monooxygenase Activity Hypotaurine Monooxygenase Activity Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Platelet Alpha Granule Lumen Proteolysis Regulation Of Cardiac Muscle Contraction Striated Muscle Contraction Endopeptidase Activity Rho GDP-dissociation Inhibitor Binding Lysosomal Lumen Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Flavin-dependent Sulfhydryl Oxidase Activity
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