RTF1 and TCEA1

Number of citations of the paper that reports this interaction (PubMedID 20178742)
48

Data Source:
BioGRID (pull down)

		RTF1	TCEA1
Description		RTF1 homolog, Paf1/RNA polymerase II complex component	transcription elongation factor A1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cdc73/Paf1 Complex	Nucleus Nucleoplasm Transcription Factor TFIID Complex Nucleolus
	Molecular Function	DNA Binding Single-stranded DNA Binding RNA Binding Protein Binding	Nucleic Acid Binding DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Endodermal Cell Fate Commitment Blastocyst Growth Chromatin Organization Transcription Elongation By RNA Polymerase II Wnt Signaling Pathway Stem Cell Population Maintenance	DNA-templated Transcription Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Erythrocyte Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins	Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 30013184) Asthma ( 32296059) Coronary artery disease ( 29212778) Eosinophil percentage of granulocytes ( 27863252) Height ( 20881960) Itch intensity from mosquito bite ( 28199695) Ulcerative colitis ( 28067908)	Urinary albumin-to-creatinine ratio ( 26631737)
Interacting Genes		4 interacting genes: APP SRPK2 TCEA1 UBC	20 interacting genes: APP CDC73 CDK7 CEBPA CIRSR CTDP1 CTR9 EAF2 GPKOW GTF2E1 GTF2F2 IWS1 LEO1 PAF1 POLR2A REXO1 RTF1 SKIC8 SUPT6H UBR5
Entrez ID		23168	6917
HPRD ID		11071	03252
Ensembl ID		ENSG00000137815	ENSG00000187735
Uniprot IDs		Q92541	A0A384MTX4 B7Z4W0 P23193
PDB IDs		2BZE 2DB9 3U1U 4L1P 4L1U 6TED 7UNC 7UND 8A3Y 9EGX 9EGY 9EGZ 9EH0 9EH1 9EH2	1TFI 3NDQ 5IY6 5IY7 5IY8 5IYA 5IYB 5IYC 6O9L 6ZUY 6ZV4 7CNF 7UNC 7UND 8A40 8UIS 9EGX 9EGY 9EGZ 9EH0 9EH1 9EH2 9J0N
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Lysosomal HOPS Complex Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Nuclear Speck Organization Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Presynapse Axon Choice Point Recognition Regulation Of Neuron Apoptotic Process Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion R-loop Processing Endosome Membrane Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding	Transcription Elongation By RNA Polymerase II DNA-templated Transcription Elongation RNA Metabolic Process Cdc73/Paf1 Complex Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Endodermal Cell Fate Commitment Nucleobase-containing Compound Biosynthetic Process Cell Fate Commitment Involved In Formation Of Primary Germ Layer Macromolecule Metabolic Process Macromolecule Biosynthetic Process Nucleoplasm Nucleus MRNA Metabolic Process Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Myeloid Cell Differentiation Regulation Of DNA-templated Transcription Elongation Regulation Of RNA Metabolic Process Stem Cell Population Maintenance Maintenance Of Cell Number Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II MRNA Processing Wnt Signaling Pathway Positive Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Cell Fate Commitment Regulation Of Macromolecule Biosynthetic Process RNA 3'-end Processing RNA Processing Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Myeloid Cell Differentiation Positive Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Complex Binding Negative Regulation Of Developmental Process Regulation Of Hemopoiesis Positive Regulation Of Biosynthetic Process Negative Regulation Of Cell Differentiation MRNA 3'-end Processing Positive Regulation Of RNA Metabolic Process Transcription Initiation At RNA Polymerase II Promoter Regulation Of Primary Metabolic Process Regulation Of Cell Differentiation
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