SEPTIN6 and CDC42EP3

Number of citations of the paper that reports this interaction (PubMedID 11584266)
0

Data Source:
BioGRID (pull down)

		SEPTIN6	CDC42EP3
Description		septin 6	CDC42 effector protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Chromosome Cytoplasm Spindle Cytoskeleton Cilium Septin Ring Synaptic Vesicle Microtubule Cytoskeleton Midbody Septin Complex Motile Cilium Cell Division Site Cleavage Furrow Septin Collar Cell Projection Axon Terminus Sperm Annulus Presynapse	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Endomembrane System Actin Cytoskeleton Membrane
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Molecular Adaptor Activity	Protein Binding Cytoskeletal Regulatory Protein Binding Small GTPase Binding
	Biological Process	Mitotic Cytokinesis Spermatogenesis Intracellular Protein Localization Cell Differentiation Cell Division Cytoskeleton-dependent Cytokinesis	Signal Transduction Rho Protein Signal Transduction Regulation Of Cell Shape Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Pseudopodium Assembly
Pathways			MAPK6/MAPK4 signaling CDC42 GTPase cycle RHOQ GTPase cycle
Drugs
Diseases
GWAS			Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Cortical volume ( 32963231) Facial attractiveness (male raters) ( 30946739) HDL cholesterol levels in HIV infection ( 33109212) Height ( 31562340 28552196 23563607 20881960) Night sleep phenotypes ( 27126917) Rheumatoid arthritis ( 30891314) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Total ventricular volume (Alzheimer's disease interaction) ( 21116278) Waist circumference adjusted for body mass index ( 34021172) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		15 interacting genes: CDC42EP2 CDC42EP3 CEBPA CRK KDM1A MORN4 NSD3 PLEKHF2 RHOU S100A4 SEPTIN1 SEPTIN2 SEPTIN9 SH3KBP1 TK1	12 interacting genes: CDC42 COPE DAPK1 LRRK1 LRRK2 MFHAS1 RHOQ SEPTIN6 SEPTIN7 SNCA SRPK1 UMPS
Entrez ID		23157	10602
HPRD ID		06716	09364
Ensembl ID		ENSG00000125354	ENSG00000163171
Uniprot IDs		B1AMS2 Q14141 Q541S4 Q548C9	Q9UKI2
PDB IDs		2QAG 6UPA 6WBP 7M6J
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Shape Cell Division Site Septin Ring Septin Complex Regulation Of Cell Morphogenesis Organelle Organization Cytoskeleton-dependent Cytokinesis Microtubule Cytoskeleton Positive Regulation Of Pseudopodium Assembly Actin Cytoskeleton Cytoskeleton Organization GTPase Activity Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization Actin Cytoskeleton Organization Regulation Of Cell Projection Organization GTP Binding Positive Regulation Of Cell Projection Organization Non-motile Cilium Actin Filament-based Process Molecular Adaptor Activity Regulation Of Anatomical Structure Morphogenesis RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Actin Filament Polymerization Cytoskeletal Regulatory Protein Binding Histone H3K4 Dimethyltransferase Activity Histone H3K27 Dimethyltransferase Activity Cytoskeleton Regulation Of Cell Projection Assembly Response To Vitamin B2 C/EBP Complex Helper T Cell Diapedesis Protein Phosphorylated Amino Acid Binding Response To Cholecystokinin Meiotic Metaphase Chromosome Alignment Thymidine Kinase Activity Endomembrane System Rho Protein Signal Transduction Regulation Of Cellular Component Size Actin Filament Organization Small GTPase-mediated Signal Transduction Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity CHOP-C/EBP Complex Regulation Of Stem Cell Proliferation Identical Protein Binding Regulation Of Developmental Process Cerebral Cortex Development Cerebellar Neuron Development Epithelial To Mesenchymal Transition	GTP Binding Nucleotide Binding GBD Domain Binding GTPase Activity Regulation Of Macrophage Activation Sperm Annulus Cytoskeleton Cytoplasm Cell Division Site Septin Ring Septin Complex Response To Type II Interferon Regulation Of SNARE Complex Assembly Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Identical Protein Binding Intracellular Signal Transduction Syntaxin-1 Binding Protein Serine Kinase Activity GTP Metabolic Process Synaptic Vesicle Protein Serine/threonine Kinase Activity Phosphate-containing Compound Metabolic Process Positive Regulation Of Endocytosis Positive Regulation Of Filopodium Assembly Regulation Of Synaptic Vesicle Recycling Endocytosis Midbody Molecular Adaptor Activity Protein Kinase Activity Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Organelle Organization Terminal Bouton Cellular Response To Oxidative Stress Magnesium Ion Binding Regulation Of Cell Projection Assembly Positive Regulation Of Cellular Component Organization Spindle Cleavage Furrow Import Into Cell Regulation Of Filopodium Assembly Postsynapse Kinase Activity DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Axon Terminus
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