PLXND1 and SEC61A1

		PLXND1	SEC61A1
Description		plexin D1	SEC61 translocon subunit alpha 1
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GO Annotations	Cellular Component	Semaphorin Receptor Complex Plasma Membrane Membrane Lamellipodium Axon Lamellipodium Membrane Cell Projection Cell Body Glutamatergic Synapse Plasma Membrane Bounded Cell Projection	Endoplasmic Reticulum Sec61 Translocon Complex Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding Semaphorin Receptor Activity Protein Domain Specific Binding	Signal Sequence Binding Calcium Channel Activity Protein Binding Protein Transmembrane Transporter Activity Ribosome Binding
	Biological Process	Angiogenesis Branching Involved In Blood Vessel Morphogenesis Kidney Development Outflow Tract Morphogenesis Cardiac Septum Development Negative Regulation Of Cell Adhesion Synapse Assembly Synaptic Target Recognition Regulation Of Cell Shape Regulation Of Cell Migration Aorta Development Negative Regulation Of Neuron Apoptotic Process Endothelial Cell Migration Regulation Of Angiogenesis Positive Regulation Of Axonogenesis Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Coronary Vasculature Development Semaphorin-plexin Signaling Pathway	Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Endoplasmic Reticulum Organization Protein Transport Post-translational Protein Targeting To Membrane, Translocation Response To Type II Interferon Pronephric Nephron Development Protein Targeting To ER Protein Insertion Into ER Membrane Calcium Ion Transmembrane Transport
Pathways		Other semaphorin interactions NOTCH3 Intracellular Domain Regulates Transcription RND2 GTPase cycle	ER-Phagosome pathway SRP-dependent cotranslational protein targeting to membrane
Drugs
Diseases
GWAS		A body shape index ( 34021172) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 25673412 34021172) Hip index ( 34021172) Low density lipoprotein cholesterol levels ( 32154731) Mean platelet volume ( 32888494) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 28448500 25673412)	Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Gestational age at birth (maternal effect) ( 28877031)
Interacting Genes		3 interacting genes: HOXB5 MACF1 SEMA4A	10 interacting genes: BAG6 CALM1 GET3 HSPA5 MLH1 PTEN SEC61G SERP1 SLC13A1 TNF
Entrez ID		23129	29927
HPRD ID		05046	15316
Ensembl ID		ENSG00000004399	ENSG00000058262
Uniprot IDs		Q9Y4D7	B3KME8 B3KNF6 B4DR61 C9JXC6 P61619
PDB IDs		3H6N	6W6L 8B6L 8DNV 8DNW 8DNX 8DNY 8DNZ 8DO0 8DO1 8DO2 8DO3
Enriched GO Terms of Interacting Partners?			Post-translational Protein Targeting To Membrane, Translocation Ribosome Binding Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Tail-anchored Membrane Protein Insertion Into ER Membrane Intracellular Signal Transduction Misfolded Protein Binding Ubiquitin-specific Protease Binding Positive Regulation Of Protein Metabolic Process Protein Insertion Into ER Membrane Intracellular Protein Transmembrane Transport Protein Targeting To ER Intrinsic Apoptotic Signaling Pathway Establishment Of Protein Localization To Endoplasmic Reticulum Protein Insertion Into Membrane Establishment Of Protein Localization Substantia Nigra Development Negative Regulation Of High Voltage-gated Calcium Channel Activity Neural Nucleus Development Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Action Potential Cell Surface Receptor Signaling Pathway Via JAK-STAT Cellular Response To Type II Interferon Protein Transmembrane Transport Response To Endoplasmic Reticulum Stress Cerebellum Structural Organization Endoplasmic Reticulum Unfolded Protein Response Regulation Of Protein Folding In Endoplasmic Reticulum Meiotic Spindle Midzone Assembly Positive Regulation Of Immunoglobulin Mediated Immune Response Meiotic Metaphase Chromosome Alignment Positive Regulation Of Immunoglobulin Production Chiasma Apoptotic Signaling Pathway Late Recombination Nodule Regulation Of Immunoglobulin Production Chromosome Organization Involved In Meiotic Cell Cycle Meiotic Metaphase I Homologous Chromosome Alignment Positive Regulation Of Proteolysis Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Wound Healing Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Sodium:sulfate Symporter Activity Monoatomic Anion:sodium Symporter Activity Negative Regulation Of Bile Acid Secretion
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