RAP1GAP2 and VPS26C

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		RAP1GAP2	VPS26C
Description		RAP1 GTPase activating protein 2	VPS26 endosomal protein sorting factor C
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Plasma Membrane Nuclear Membrane Perinuclear Region Of Cytoplasm	Nucleus Endosome
	Molecular Function	GTPase Activator Activity Protein Binding	Protein Binding
	Biological Process	Adaptive Immune Response Regulation Of Cell Size Regulation Of Small GTPase Mediated Signal Transduction	Intracellular Protein Transport Endocytic Recycling
Pathways		Rap1 signalling
Drugs
Diseases
GWAS		Asthma (sex interaction) ( 24824216) Basophil count ( 32888494) Eosinophil count ( 32888494) Femur bone mineral density x serum urate levels interaction ( 34046847) Inflammatory skin disease ( 25574825) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494) PR interval in Tripanosoma cruzi seropositivity ( 24324551) Pre-treatment viral load in HIV-1 infection ( 31219150) Prepulse inhibition of the startle response ( 31596458) Serum metabolite levels ( 33031748) Tonsillectomy ( 27182965 28928442) White blood cell count ( 32888494)
Interacting Genes		4 interacting genes: MEOX2 VPS26C YWHAE YWHAZ	44 interacting genes: AGTPBP1 ARHGAP21 ASH1L CBLB CCDC85A CIPC DCLK1 DDIT4L DECR2 DNAJB2 EPHB6 INCA1 KIF1A KIF21A LRIF1 MAML3 MAPK6 MAPK8IP1 MDM4 MEI4 MEOX2 MRPS35 MYRIP NRCAM NSMF PALS2 PCM1 PEG10 PMS2 PRKD2 PTPN21 RAB39B RAP1GAP RAP1GAP2 SETMAR TAF1C TEPSIN TET2 TRAPPC1 U2AF1 VPS26A VPS35L XPA ZNF655
Entrez ID		23108	10311
HPRD ID		17028	10390
Ensembl ID		ENSG00000132359	ENSG00000157538
Uniprot IDs		A0A1B0GV05 A0A8V8TKZ8 A0A8V8TL16 Q684P5	A8MTY9 A8MY26 O14972
PDB IDs			8P0X 8SYN 8SYO 9AU7
Enriched GO Terms of Interacting Partners?		Phosphoserine Residue Binding Protein Sequestering Activity Protein Phosphatase Binding Melanosome Establishment Of Localization In Cell Transmembrane Transporter Binding Regulation Of Heart Rate By Hormone Vesicle-mediated Transport To The Plasma Membrane Synaptic Target Recognition Somite Specification Regulation Of Heart Rate By Chemical Signal Protein Targeting Negative Regulation Of Calcium Ion Export Across Plasma Membrane Golgi Reassembly Protein Domain Specific Binding Regulation Of Calcium Ion Export Across Plasma Membrane MAPK Cascade Positive Regulation Of Toll-like Receptor Signaling Pathway
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