MRPS27 and FCHO2

		MRPS27	FCHO2
Description		mitochondrial ribosomal protein S27	FCH and mu domain containing endocytic adaptor 2
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GO Annotations	Cellular Component	Nucleolus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Small Ribosomal Subunit Ribosome Ribonucleoprotein Complex	Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit Membrane Clathrin-coated Vesicle Synapse Presynapse
	Molecular Function	TRNA Binding RNA Binding Protein Binding RRNA Binding	Phosphatidylserine Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol Binding Identical Protein Binding
	Biological Process	Regulation Of Translation Cell Population Proliferation Mitochondrial Translation	Endocytosis Membrane Invagination Clathrin Coat Assembly Synaptic Vesicle Endocytosis Clathrin-dependent Endocytosis Protein Localization To Plasma Membrane
Pathways		Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination Mitochondrial ribosome-associated quality control	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Refractive error ( 32231278)	Albumin-globulin ratio ( 29403010) Aspartate aminotransferase levels ( 33547301 33339817 29403010) Discordance in emotional problems in monozygotic twins ( 27043157) Eyebrow thickness ( 26926045) Factor VIII levels ( 30586737) Heel bone mineral density ( 30598549) Immunoglobulin measurement (zinc sulfate turbidity test) ( 29403010) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean corpuscular hemoglobin concentration ( 32888494) Mean platelet volume ( 32888494) Monobrow thickness ( 26926045) Non-albumin protein levels ( 29403010) Red cell distribution width ( 32888494 27863252) Serum albumin levels ( 29403010) Small cell lung carcinoma ( 28604730) vWF levels ( 30586737) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549)
Interacting Genes		5 interacting genes: CFTR NECAB2 PTEN SNRNP48 YWHAQ	6 interacting genes: DAB2 EPS15 EPS15L1 ITSN1 RHOU UBC
Entrez ID		23107	115548
HPRD ID		17596	13319
Ensembl ID		ENSG00000113048	ENSG00000157107
Uniprot IDs		G5EA06 Q6PKB3 Q92552	Q0JRZ9
PDB IDs		3J9M 6NU2 6NU3 6RW4 6RW5 6VLZ 6VMI 6ZM5 6ZM6 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG 7A5F 7A5G 7A5I 7A5K 7L08 7OG4 7P2E 7PNX 7PNY 7PNZ 7PO0 7PO1 7PO2 7PO3 7QI4 7QI5 7QI6 8ANY 8CSP 8CSQ 8CSR 8CSS 8CST 8CSU 8K2A 8OIR 8OIS 8QRK 8QRL 8QRM 8QRN 8RRI 8XT0 8XT2	2V0O 7OG1 7OHO 7OHZ 7OI5 7OIQ 7OIT
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transport 14-3-3 Protein Binding Regulation Of Transport Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding PDZ Domain Binding Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Synapse Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Somatostatin Secretion Positive Regulation Of Epinephrine Secretion Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Monoatomic Anion Transport Central Nervous System Myelin Maintenance Circadian Rhythm Rhythmic Synaptic Transmission Regulation Of Nervous System Process Negative Regulation Of Glucagon Secretion Positive Regulation Of Adenosine Receptor Signaling Pathway A2A Adenosine Receptor Binding Positive Regulation Of Enamel Mineralization Adult Behavior Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Type 5 Metabotropic Glutamate Receptor Binding Regulation Of Insulin Secretion Transepithelial Water Transport Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Phosphatidylinositol Phosphate Phosphatase Activity Regulation Of Peptide Hormone Secretion Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Synaptic Vesicle Clustering Postsynaptic Density Assembly Positive Regulation Of Transmission Of Nerve Impulse Regulation Of Glucagon Secretion Developmental Maturation Identical Protein Binding Bicarbonate Transmembrane Transporter Activity Positive Regulation Of Cell Communication Intracellular PH Elevation	Clathrin-coated Pit Endocytosis Protein-macromolecule Adaptor Activity Import Into Cell Clathrin Coat Of Coated Pit Postsynaptic Endocytic Zone Vesicle-mediated Transport In Synapse Clathrin Coat Assembly Vesicle-mediated Transport Receptor-mediated Endocytosis Endosomal Transport Synaptic Vesicle Endocytosis Presynaptic Endocytosis Clathrin-coated Vesicle Leading Edge Cell Differentiation Clathrin-dependent Synaptic Vesicle Endocytosis Positive Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of Aldosterone Biosynthetic Process Positive Regulation Of Aldosterone Secretion Calcium Ion Binding Positive Regulation Of Hormone Secretion Positive Regulation Of Caveolin-mediated Endocytosis Positive Regulation Of Endocytosis Plasma Membrane Positive Regulation Of Steroid Hormone Biosynthetic Process Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Hormone Biosynthetic Process Regulation Of Aldosterone Biosynthetic Process Postsynaptic Neurotransmitter Receptor Internalization Ubiquitin-dependent Endocytosis Guanyl-nucleotide Exchange Factor Activity Regulation Of Caveolin-mediated Endocytosis Positive Regulation Of Growth Hormone Secretion Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Focal Adhesion Disassembly Postsynaptic Actin Cytoskeleton Regulation Of Protein Localization AP-2 Adaptor Complex Regulation Of Hormone Secretion Cytosol Receptor-mediated Endocytosis Of Virus By Host Cell Positive Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Secretion By Cell Golgi To Endosome Transport Positive Regulation Of Receptor Recycling Endocytosis Involved In Viral Entry Into Host Cell Regulation Of Growth Hormone Secretion Regulation Of Modification Of Postsynaptic Structure
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