ARHGAP26 and ACSL6

		ARHGAP26	ACSL6
Description		Rho GTPase activating protein 26	acyl-CoA synthetase long chain family member 6
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Endosome Cytosol Cytoskeleton Focal Adhesion Endosome Membrane Membrane Anchoring Junction	Mitochondrion Mitochondrial Outer Membrane Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane
	Molecular Function	GTPase Activator Activity Protein Binding Phospholipid Binding Protein-macromolecule Adaptor Activity	Nucleotide Binding Long-chain Fatty Acid-CoA Ligase Activity Protein Binding ATP Binding Ligase Activity Enzyme Binding Protein Homodimerization Activity Arachidonate-CoA Ligase Activity
	Biological Process	Mitophagy Signal Transduction Actin Cytoskeleton Organization Regulation Of Small GTPase Mediated Signal Transduction	Very Long-chain Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Acyl-CoA Metabolic Process Neuroblast Proliferation Long-chain Fatty-acyl-CoA Biosynthetic Process
Pathways		RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle	Synthesis of very long-chain fatty acyl-CoAs
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Atrial fibrillation ( 29892015) Coronary artery disease ( 29212778) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Heel bone mineral density ( 28869591 30598549) Height ( 31562340) LDL cholesterol levels in HIV infection ( 33109212) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244) Myocardial infarction ( 33532862) Night sleep phenotypes ( 27126917) PR interval ( 32439900) Pulse pressure ( 27841878) Septic shock resolution ( 32755526) Suicide attempt severity in mood disorders ( 33783297) Waist circumference ( 28552196)	Alzheimer's disease in APOE e4- carriers ( 25778476) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 22412388 28067908) Inflammatory bowel disease ( 23128233 28067908) Perceived unattractiveness to mosquitoes ( 28199695) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		8 interacting genes: CDC42 CDC42EP2 INSR PKN1 PKN3 PTK2 RHOA SRPK1	3 interacting genes: PCMTD2 PHYH ZNF655
Entrez ID		23092	23305
HPRD ID		05643	09190
Ensembl ID		ENSG00000145819	ENSG00000164398
Uniprot IDs		A0A0S2Z536 A0A2R8YGB3 Q9UNA1	A0A494BZW8 A0A494C0B6 A0A494C0J9 A0A499FJL5 B2RB13 B4DFW3 C9J8C7 Q9UKU0
PDB IDs		1UGV
Enriched GO Terms of Interacting Partners?		Nucleotide Binding Protein Phosphorylation Phosphorylation Protein Kinase Activity Kinase Activity Establishment Of Cell Polarity Positive Regulation Of Pseudopodium Assembly ATP Binding Phosphate-containing Compound Metabolic Process Establishment Of Epithelial Cell Apical/basal Polarity Diacylglycerol-dependent Serine/threonine Kinase Activity Ameboidal-type Cell Migration Cell Migration Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Intracellular Signal Transduction Establishment Or Maintenance Of Monopolar Cell Polarity Positive Regulation Of Cytoskeleton Organization Regulation Of Locomotion Positive Regulation Of Organelle Organization Polarized Epithelial Cell Differentiation Positive Regulation Of Supramolecular Fiber Organization Establishment Of Epithelial Cell Polarity Establishment Or Maintenance Of Cell Polarity Regulation Of Cell Motility Regulation Of Cytoskeleton Organization Midbody Signal Transduction Cell Motility Positive Regulation Of Cell Migration Dendritic Spine Organization Wnt Signaling Pathway, Planar Cell Polarity Pathway Epithelial Cell Migration Positive Regulation Of Cell Motility Plasma Membrane Regulation Of Cell-substrate Adhesion Regulation Of Organelle Organization Positive Regulation Of Locomotion Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cytokinesis Neuron Projection Organization Substantia Nigra Development Postsynapse Organization Membrane Invagination Actin Filament Organization Positive Regulation Of Cell Cycle Process Regulation Of Actin Filament Organization Small GTPase-mediated Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Non-canonical Wnt Signaling Pathway	Glycine Amidinotransferase Activity Amidinotransferase Activity Homogentisate 1,2-dioxygenase Activity 2-oxobutyrate Catabolic Process Phytanoyl-CoA Dioxygenase Activity
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