ZHX3 and ZHX2

Number of citations of the paper that reports this interaction (PMID 14659886)
7

Data Source:
BioGRID (two hybrid)
HPRD (in vitro, in vivo, two hybrid)

		ZHX3	ZHX2
Gene Name		zinc fingers and homeoboxes 3	zinc fingers and homeoboxes 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm Cytoplasm Plasma Membrane
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Cell Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated MRNA Catabolic Process Somatic Stem Cell Maintenance Negative Regulation Of Neuron Differentiation Negative Regulation Of Transcription, DNA-templated
Pathways
Drugs
Diseases
GWAS			Carotid intima media thickness ( 21909108) Immune response to smallpox vaccine (IL-6) ( 22542470)
Protein-Protein Interactions		5 interactors: ATXN1 NFYA NLK ZHX1 ZHX2	9 interactors: APP ATXN1 DHRS2 LAT NAGPA NFYA YWHAQ ZHX1 ZHX3
Entrez ID		23051	22882
HPRD ID		10320	16458
Ensembl ID		ENSG00000174306	ENSG00000178764
Uniprot IDs		F5H820 Q9H4I2	Q9Y6X8
PDB IDs		2DA5 2DN0	2DMP 3NAU
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Serine Phosphorylation Of STAT3 Protein Negative Regulation Of Transcription, DNA-templated Serine Phosphorylation Of STAT Protein Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Metabolic Process Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Stem Cell Maintenance Negative Regulation Of Cellular Metabolic Process Peptidyl-threonine Phosphorylation Lung Alveolus Development Regulation Of Cell Development Visual Learning Visual Behavior Somatic Stem Cell Maintenance Cellular Metabolic Process Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Stem Cell Proliferation Regulation Of Postsynaptic Membrane Potential Positive Regulation Of Transcription From RNA Polymerase II Promoter Associative Learning Negative Regulation Of Signal Transduction Regulation Of JAK-STAT Cascade	Intracellular Transport Visual Learning Regulation Of Transcription From RNA Polymerase II Promoter Visual Behavior Establishment Of Localization In Cell Associative Learning Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Gene Expression Synaptic Growth At Neuromuscular Junction Adult Locomotory Behavior Negative Regulation Of Gene Expression Cellular Localization Negative Regulation Of Biosynthetic Process Collateral Sprouting In Absence Of Injury Learning Cell Activation Adult Behavior Regulation Of Transcription, DNA-templated Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Platelet Activation Negative Regulation Of Transcription From RNA Polymerase II Promoter Axon Choice Point Recognition Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Locomotory Behavior RNA Metabolic Process Neuron Remodeling Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Steroid Metabolic Process Learning Or Memory Protein Targeting To Lysosome Cognition Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Localization To Lysosome Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Developmental Process Response To Light Stimulus Exocytosis Cellular Copper Ion Homeostasis Transcription, DNA-templated RNA Biosynthetic Process
Tagcloud ?			adm cddp chemotherapeutic chemotherapeutics chip clarify consistently efflux eliminated enhances fingers greatly hcc hepatocellular hepg2 homeoboxes interacted inverse luciferase mdr1 multidrug mutating myeloma repress repressed represses repression y ya
Tagcloud (Difference) ?			adm cddp chemotherapeutic chemotherapeutics chip clarify consistently efflux eliminated enhances fingers greatly hcc hepatocellular hepg2 homeoboxes interacted inverse luciferase mdr1 multidrug mutating myeloma repress repressed represses repression y ya
Tagcloud (Intersection) ?