SMNDC1 and PRPF19

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		SMNDC1	PRPF19
Description		survival motor neuron domain containing 1	pre-mRNA processing factor 19
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cajal Body Nuclear Speck	Prp19 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Spliceosomal Complex Cytoplasm Lipid Droplet Spindle Cytoskeleton Membrane Nuclear Speck Site Of Double-strand Break U2-type Catalytic Step 1 Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	RNA Binding Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin-ubiquitin Ligase Activity Identical Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	RNA Splicing, Via Transesterification Reactions MRNA Processing Apoptotic Process RNA Splicing	DNA Damage Checkpoint Signaling Protein Polyubiquitination Spliceosomal Tri-snRNP Complex Assembly Spliceosomal Complex Assembly MRNA Splicing, Via Spliceosome Inner Cell Mass Cell Proliferation DNA Repair Double-strand Break Repair Via Nonhomologous End Joining MRNA Processing DNA Damage Response Intracellular Protein Localization RNA Splicing Lipid Biosynthetic Process Proteasomal Protein Catabolic Process Protein Ubiquitination Positive Regulation Of MRNA Splicing, Via Spliceosome Protein K63-linked Ubiquitination
Pathways		mRNA Splicing - Major Pathway	Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Crohn's disease ( 23850713) Refractive error ( 32231278)
Interacting Genes		6 interacting genes: CEBPA H3-4 KPNB1 PRPF19 SNRNP200 SNRPB	24 interacting genes: CEBPA CTBP1 DDX42 DNTT EGLN3 ESR1 EXOC7 GATA4 GSTK1 HSPB1 MYL9 OGT POLR2A PSMB4 PTEN RBFOX2 RPA1 RPA3 SETMAR SMNDC1 U2AF1 UBE2D3 USP7 VPS35
Entrez ID		10285	27339
HPRD ID		04627	12214
Ensembl ID		ENSG00000119953	ENSG00000110107
Uniprot IDs		O75940	Q9UMS4
PDB IDs		4A4F 4A4H 8POI	4LG8 5MQF 5XJC 5YZG 5Z56 5Z57 6FF7 6ICZ 6ID0 6ID1 6QDV 7A5P 7W59 7W5A 7W5B 8C6J 8CH6 8I0T 8I0U 8I0V 8I0W 8RO2 9FMD
Enriched GO Terms of Interacting Partners?		Catalytic Step 2 Spliceosome U2-type Catalytic Step 1 Spliceosome MRNA Splicing, Via Spliceosome Spliceosomal Complex Small Nuclear Ribonucleoprotein Complex Protein-RNA Complex Assembly RNA Splicing, Via Transesterification Reactions U5 SnRNP U2-type Catalytic Step 2 Spliceosome U4/U6 X U5 Tri-snRNP Complex Spliceosomal SnRNP Assembly Spliceosomal Complex Assembly U2-type Precatalytic Spliceosome Nucleoplasm RNA Splicing Cellular Component Assembly MRNA Processing RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Spliceosome Conformational Change To Release U4 (or U4atac) And U1 (or U11) Protein-containing Complex Assembly RNA Metabolic Process Protein-containing Complex Organization Response To Vitamin B2 C/EBP Complex U2 SnRNP Binding Cis Assembly Of Pre-catalytic Spliceosome MRNA Metabolic Process CHOP-C/EBP Complex SnRNP Binding White Fat Cell Proliferation Mitotic Chromosome Movement Towards Spindle Pole Ribosomal Protein Import Into Nucleus RNA Import Into Nucleus Histone Pre-mRNA DCP Binding Spermatogonial Cell Division Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Response To Phenylpropanoid Nucleic Acid Metabolic Process U7 SnRNP RNA Processing Histone Pre-mRNA 3'end Processing Complex U1 SnRNP Binding DNA Replication-dependent Chromatin Assembly Protein Domain Specific Binding Nucleus Fat Cell Proliferation 7-methylguanosine Cap Hypermethylation Importin-alpha Family Protein Binding NLS-dependent Protein Nuclear Import Complex	Nucleoplasm Nucleus Nucleic Acid Metabolic Process Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process DNA Repair Nucleotide-excision Repair DNA Damage Response Regulation Of Ubiquitin-dependent Protein Catabolic Process DNA-binding Transcription Factor Binding Nucleic Acid Binding Cajal Body RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Autophagy DNA Replication Factor A Complex White Fat Cell Differentiation Double-strand Break Repair Site Of Double-strand Break Response To Stress DNA Metabolic Process Rhythmic Process Estrogen Receptor Signaling Pathway PML Body Single-stranded DNA Binding Negative Regulation Of Protein Catabolic Process Mismatch Repair Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stress Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Response To Nutrient Condensed Chromosome Base-excision Repair RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding DNA Nucleotidylexotransferase Activity Negative Regulation Of Protein Kinase C Signaling Negative Regulation Of Synaptic Vesicle Clustering Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Terminal Button Organization Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription Coregulator Binding Regulation Of Protein Catabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Proteolysis Negative Regulation Of Catabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Carbohydrate Homeostasis
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