NLGN1 and NRXN3

Number of citations of the paper that reports this interaction (PubMedID 8576240)
0

Data Source:
BioGRID (pull down)

		NLGN1	NRXN3
Description		neuroligin 1	neurexin 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Golgi Apparatus Plasma Membrane Cell Surface Postsynaptic Density Membrane Dendrite Neuromuscular Junction Filopodium Tip Synaptic Cleft Dendritic Spine Receptor Complex Synapse Postsynaptic Membrane Excitatory Synapse Synaptic Membrane Protein Complex Involved In Cell-cell Adhesion Presynapse Postsynapse Glutamatergic Synapse GABA-ergic Synapse Neuron To Neuron Synapse Asymmetric, Glutamatergic, Excitatory Synapse Postsynaptic Specialization Membrane	Plasma Membrane Membrane Presynaptic Membrane Cell Projection Synapse Trans-synaptic Protein Complex
	Molecular Function	Amyloid-beta Binding PDZ Domain Binding Signaling Receptor Activity Neurexin Family Protein Binding Identical Protein Binding Cell Adhesion Molecule Binding Scaffold Protein Binding	Transmembrane Signaling Receptor Activity Protein Binding Signaling Receptor Activity Metal Ion Binding Cell Adhesion Molecule Binding Neuroligin Family Protein Binding
	Biological Process	Protein Targeting Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Neuron Cell-cell Adhesion Nervous System Development Synapse Assembly Positive Regulation Of Circadian Sleep/wake Cycle, Wakefulness Synaptic Vesicle Targeting Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Neuronal Signal Transduction Neuron Projection Development Positive Regulation Of Synaptic Transmission, GABAergic Protein Localization To Synapse Establishment Of Protein Localization Regulation Of Neuron Differentiation Rhythmic Process Cytoskeletal Matrix Organization At Active Zone Neuron Projection Morphogenesis Modulation Of Chemical Synaptic Transmission Positive Regulation Of Filopodium Assembly Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Dendritic Spine Development Negative Regulation Of Dendritic Spine Morphogenesis Cellular Response To Calcium Ion Terminal Button Organization Synaptic Vesicle Clustering Postsynaptic Membrane Assembly Presynaptic Membrane Assembly AMPA Glutamate Receptor Clustering NMDA Glutamate Receptor Clustering Neurexin Clustering Involved In Presynaptic Membrane Assembly Postsynaptic Density Protein 95 Clustering Receptor Localization To Synapse NMDA Selective Glutamate Receptor Signaling Pathway AMPA Selective Glutamate Receptor Signaling Pathway Presynapse Assembly Neuron Projection Arborization Positive Regulation Of Ruffle Assembly Positive Regulation Of Neuromuscular Synaptic Transmission Positive Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Intracellular Signal Transduction Excitatory Synapse Assembly Positive Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Excitatory Postsynaptic Potential	Angiogenesis Cell Adhesion Neuron Cell-cell Adhesion Signal Transduction Nervous System Development Axon Guidance Learning Adult Behavior Social Behavior Vocalization Behavior
Pathways		Neurexins and neuroligins Neurexins and neuroligins	Neurexins and neuroligins Neurexins and neuroligins Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adventurousness ( 30643258) Adverse response to drug ( 30420678) Bipolar disorder or attention deficit hyperactivity disorder ( 27890468) Frailty index ( 34431594) Hand grip strength ( 29691431) Major depressive disorder ( 20516156) Metabolite levels ( 23823483) Motion sickness ( 25628336) Periodontitis (DPAL) ( 24024966) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Triglyceride levels ( 32154731) Triglyceride levels in HIV infection ( 33109212) Waist-to-hip ratio adjusted for BMI ( 28552196) Weight ( 28552196)	Adiponectin levels ( 33562295) Adult body size ( 32376654) Amyotrophic lateral sclerosis (age of onset) ( 22959728) Blood pressure (smoking interaction) ( 25189868) Blood protein levels ( 30072576) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 20935630 28892062 28552196 28448500 26865924 25673413) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Bone mineral density (hip) ( 30172743) Chronotype ( 30696823) Coronary artery aneurysm in Kawasaki disease ( 27171184) Daytime nap ( 33568662) Depression x maternal smoking during pregnancy interaction ( 34118634) Electrodermal activity ( 25387706) Figural/spatial cognitive ability ( 31620175) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference ( 25673412) JT interval (sulfonylurea treatment interaction) ( 27958378) Medial orbital frontal cortex volume ( 31530798) Normal facial asymmetry (angle of deformation score) ( 30631343) Obesity ( 21552555 23563607) Objective response to lithium treatment in bipolar disorder ( 26503763) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Postherpetic neuralgia ( 33685280) Proliferative diabetic retinopathy in type 2 diabetes ( 29739359) Response to antidepressants (symptom improvement) ( 29160301) Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260) Smoking initiation ( 33082346) Tea consumption ( 31046077) TPE interval (recovery after exercise) ( 32386560) Type 2 diabetes ( 30054458 28566273 30297969) Underweight status ( 25133637) Urinary sodium excretion ( 31409800) Waist circumference ( 19557197 25673412) Waist-hip ratio ( 25673412) Walking pace ( 33128006) Weight ( 28552196)
Interacting Genes		6 interacting genes: DLG2 DLG3 DLG4 NRXN1 NRXN2 NRXN3	8 interacting genes: AFDN CASK DNAJC5 HTR6 NLGN1 NLGN2 NLGN3 PAX4
Entrez ID		22871	9369
HPRD ID		07195	08989
Ensembl ID		ENSG00000169760	ENSG00000021645
Uniprot IDs		A0A8Q3SHM6 Q8N2Q7	A0A0A0MR89 A0A0U1RQC5 Q9HDB5 Q9Y4C0
PDB IDs		5OJ6 5OJK
Enriched GO Terms of Interacting Partners?		Neuroligin Family Protein Binding Receptor Clustering Protein Localization To Synapse Protein Localization To Cell Junction Vocalization Behavior Cell-cell Adhesion Receptor Localization To Synapse Social Behavior Neuromuscular Junction Chemical Synaptic Transmission Protein Localization To Membrane Neuron Cell-cell Adhesion Cell Adhesion Trans-synaptic Signaling Synaptic Signaling Ionotropic Glutamate Receptor Binding Learning Localization Within Membrane Cell-cell Signaling Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Signaling Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell Communication Establishment Or Maintenance Of Apical/basal Cell Polarity Learning Or Memory Gephyrin Clustering Involved In Postsynaptic Density Assembly Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels NMDA Selective Glutamate Receptor Signaling Pathway Trans-synaptic Protein Complex Postsynaptic Density Protein 95 Clustering Cognition Postsynaptic Membrane Assembly Synapse Vocal Learning Cell Adhesion Molecule Binding Postsynaptic Membrane Organization Observational Learning Kinase Binding Postsynaptic Density Membrane Juxtaparanode Region Of Axon Acetylcholine Receptor Binding Neurotransmitter-gated Ion Channel Clustering Cellular Response To Potassium Ion Auditory Behavior Presynaptic Membrane Cell Projection Mechanosensory Behavior Adult Behavior Establishment Or Maintenance Of Cell Polarity Glutamatergic Synapse	Neurexin Family Protein Binding Postsynaptic Membrane Assembly Postsynaptic Membrane Organization Presynaptic Membrane Assembly Neuron To Neuron Synapse Presynaptic Membrane Organization Presynapse Assembly Neuron Cell-cell Adhesion Cell Adhesion Molecule Binding Presynapse Organization Excitatory Synapse Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Symmetric, GABA-ergic, Inhibitory Synapse Asymmetric, Glutamatergic, Excitatory Synapse Modulation Of Excitatory Postsynaptic Potential Terminal Button Organization Membrane Assembly Positive Regulation Of Synapse Assembly Postsynaptic Density Protein 95 Clustering Cell Junction Assembly Regulation Of Synaptic Transmission, Glutamatergic Synapse Assembly Regulation Of Respiratory Gaseous Exchange By Nervous System Process Positive Regulation Of Cell Junction Assembly Neurotransmitter-gated Ion Channel Clustering Cell Adhesion Regulation Of Nervous System Process Regulation Of Respiratory System Process Synapse Positive Regulation Of Synaptic Transmission, GABAergic Cell Junction Organization Positive Regulation Of Synaptic Transmission Cell-cell Adhesion Modulation Of Chemical Synaptic Transmission Regulation Of Synapse Assembly Regulation Of Respiratory Gaseous Exchange Postsynaptic Specialization Membrane Cell-cell Signaling Regulation Of Synaptic Transmission, GABAergic Signaling Cell Communication Presynapse Postsynaptic Membrane Positive Regulation Of Dendritic Spine Development Synapse Organization Regulation Of Cell Junction Assembly Positive Regulation Of Nervous System Development Regulation Of Synaptic Vesicle Exocytosis Receptor Clustering
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