NLGN1

Description		neuroligin 1
Image
GO Annotations	Cellular Component	Extracellular Region Golgi Apparatus Plasma Membrane Cell Surface Postsynaptic Density Membrane Dendrite Neuromuscular Junction Filopodium Tip Synaptic Cleft Dendritic Spine Receptor Complex Synapse Postsynaptic Membrane Excitatory Synapse Synaptic Membrane Protein Complex Involved In Cell-cell Adhesion Presynapse Postsynapse Glutamatergic Synapse GABA-ergic Synapse Neuron To Neuron Synapse Asymmetric, Glutamatergic, Excitatory Synapse Postsynaptic Specialization Membrane
	Molecular Function	Amyloid-beta Binding PDZ Domain Binding Signaling Receptor Activity Neurexin Family Protein Binding Identical Protein Binding Cell Adhesion Molecule Binding Scaffold Protein Binding
	Biological Process	Protein Targeting Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Neuron Cell-cell Adhesion Nervous System Development Synapse Assembly Positive Regulation Of Circadian Sleep/wake Cycle, Wakefulness Synaptic Vesicle Targeting Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Neuronal Signal Transduction Neuron Projection Development Positive Regulation Of Synaptic Transmission, GABAergic Protein Localization To Synapse Establishment Of Protein Localization Regulation Of Neuron Differentiation Rhythmic Process Cytoskeletal Matrix Organization At Active Zone Neuron Projection Morphogenesis Modulation Of Chemical Synaptic Transmission Positive Regulation Of Filopodium Assembly Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Dendritic Spine Development Negative Regulation Of Dendritic Spine Morphogenesis Cellular Response To Calcium Ion Terminal Button Organization Synaptic Vesicle Clustering Postsynaptic Membrane Assembly Presynaptic Membrane Assembly AMPA Glutamate Receptor Clustering NMDA Glutamate Receptor Clustering Neurexin Clustering Involved In Presynaptic Membrane Assembly Postsynaptic Density Protein 95 Clustering Receptor Localization To Synapse NMDA Selective Glutamate Receptor Signaling Pathway AMPA Selective Glutamate Receptor Signaling Pathway Presynapse Assembly Neuron Projection Arborization Positive Regulation Of Ruffle Assembly Positive Regulation Of Neuromuscular Synaptic Transmission Positive Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Intracellular Signal Transduction Excitatory Synapse Assembly Positive Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adventurousness ( 30643258) Adverse response to drug ( 30420678) Bipolar disorder or attention deficit hyperactivity disorder ( 27890468) Frailty index ( 34431594) Hand grip strength ( 29691431) Major depressive disorder ( 20516156) Metabolite levels ( 23823483) Motion sickness ( 25628336) Periodontitis (DPAL) ( 24024966) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Triglyceride levels ( 32154731) Triglyceride levels in HIV infection ( 33109212) Waist-to-hip ratio adjusted for BMI ( 28552196) Weight ( 28552196)
Interacting Genes		6 interacting genes: DLG2 DLG3 DLG4 NRXN1 NRXN2 NRXN3
Entrez ID		22871
HPRD ID		07195
Ensembl ID		ENSG00000169760
Uniprot IDs		A0A8Q3SHM6 Q8N2Q7
PDB IDs		5OJ6 5OJK
Enriched GO Terms of Interacting Partners?		Neuroligin Family Protein Binding Receptor Clustering Protein Localization To Synapse Protein Localization To Cell Junction Vocalization Behavior Cell-cell Adhesion Receptor Localization To Synapse Social Behavior Neuromuscular Junction Chemical Synaptic Transmission Protein Localization To Membrane Neuron Cell-cell Adhesion Cell Adhesion Trans-synaptic Signaling Synaptic Signaling Ionotropic Glutamate Receptor Binding Learning Localization Within Membrane Cell-cell Signaling Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Signaling Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell Communication Establishment Or Maintenance Of Apical/basal Cell Polarity Learning Or Memory Gephyrin Clustering Involved In Postsynaptic Density Assembly Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels NMDA Selective Glutamate Receptor Signaling Pathway Trans-synaptic Protein Complex Postsynaptic Density Protein 95 Clustering Cognition Postsynaptic Membrane Assembly Synapse Vocal Learning Cell Adhesion Molecule Binding Postsynaptic Membrane Organization Observational Learning Kinase Binding Postsynaptic Density Membrane Juxtaparanode Region Of Axon Acetylcholine Receptor Binding Neurotransmitter-gated Ion Channel Clustering Cellular Response To Potassium Ion Auditory Behavior Presynaptic Membrane Cell Projection Mechanosensory Behavior Adult Behavior Establishment Or Maintenance Of Cell Polarity Glutamatergic Synapse
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