R3HDM2 and SPRY1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		R3HDM2	SPRY1
Gene Name		R3H domain containing 2	sprouty homolog 1, antagonist of FGF signaling (Drosophila)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Cytosol Plasma Membrane
	Molecular Function	Poly(A) RNA Binding	Protein Binding
	Biological Process		Establishment Of Mitotic Spindle Orientation Metanephros Development Ureteric Bud Development Organ Induction Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Negative Regulation Of Ras GTPase Activity Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of MAP Kinase Activity Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Bud Elongation Involved In Lung Branching Negative Regulation Of ERK1 And ERK2 Cascade
Pathways			Signaling by EGFR EGFR downregulation Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer
Drugs
Diseases
GWAS		Urate levels ( 20884846)
Protein-Protein Interactions		10 interactors: ATXN1 C1orf94 FAM168A KRTAP10-3 KRTAP10-8 KRTAP3-2 NOTCH2NL RBPMS REL SPRY1	27 interactors: ATXN7 CACNA1A CREB5 GEMIN4 GRB2 HEXIM2 HOXA1 HRG KPNA2 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-2 LCE1B LCE2D MDFI MEOX2 NOTCH2NL OTX1 R3HDM2 SOCS4 SPRY2 STAT3 YY1
Entrez ID		22864	10252
HPRD ID		13827	06782
Ensembl ID		ENSG00000179912	ENSG00000164056
Uniprot IDs		B7ZL65 E9PAL1 Q9Y2K5	O43609
PDB IDs		1WHR
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Signal Transduction Lung Development Respiratory Tube Development Regulation Of Signaling Regulation Of Neurotrophin TRK Receptor Signaling Pathway Respiratory System Development Regulation Of Phosphorylation Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Bud Elongation Involved In Lung Branching Regulation Of Phosphorus Metabolic Process Positive Regulation Of Interleukin-12 Biosynthetic Process Negative Regulation Of Phosphorylation Positive Regulation Of SMAD Protein Import Into Nucleus Regulation Of Interleukin-12 Biosynthetic Process Regulation Of SMAD Protein Import Into Nucleus Negative Regulation Of Ras GTPase Activity Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Branch Elongation Of An Epithelium Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway	Organ Development Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Development System Development Developmental Process Anatomical Structure Morphogenesis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Negative Regulation Of ERBB Signaling Pathway Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Pattern Specification Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Embryonic Organ Development Regulation Of ERBB Signaling Pathway Regulation Of Phosphorylation Pons Development Anterior/posterior Pattern Specification Inner Ear Morphogenesis Sensory Organ Development Regulation Of Phosphorus Metabolic Process Organ Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Organ Morphogenesis Embryonic Morphogenesis Ear Morphogenesis Negative Regulation Of Signal Transduction Metencephalon Development Embryo Development Transcription, DNA-templated Negative Regulation Of Signaling Negative Regulation Of Phosphorylation RNA Biosynthetic Process Hindbrain Development RNA Metabolic Process Regulation Of Gene Expression Response To Organic Substance Positive Regulation Of Transcription, DNA-templated Inner Ear Development Transcription From RNA Polymerase II Promoter Negative Regulation Of Protein Kinase Activity Keratinization Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription
Tagcloud ?			adaptors coimmunoprecipitated comprises dok1 epcs epo epor erythroblast erythroblasts gab1 hemoglobinizing homo irs2 orf phosphoproteomics phosphotyrosine primates propagates py rhex sapiens sh2d2a shc1 sprouty spry2 stam2 transducing ut7epo validating
Tagcloud (Difference) ?			adaptors coimmunoprecipitated comprises dok1 epcs epo epor erythroblast erythroblasts gab1 hemoglobinizing homo irs2 orf phosphoproteomics phosphotyrosine primates propagates py rhex sapiens sh2d2a shc1 sprouty spry2 stam2 transducing ut7epo validating
Tagcloud (Intersection) ?