FGF23 and PHEX

Number of citations: 0 (PubMedID 11409890)
Data Source: HPRD (in vitro)

		FGF23	PHEX
Name		fibroblast growth factor 23	phosphate regulating endopeptidase X-linked
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen	Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Fibroblast Growth Factor Receptor Binding Type 1 Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	MAPK Cascade Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Phosphate Transport Positive Regulation Of Vitamin D 24-hydroxylase Activity Neurogenesis Cell Differentiation Regulation Of Cell Migration Regulation Of Bone Mineralization Negative Regulation Of Bone Mineralization Intracellular Phosphate Ion Homeostasis Response To Magnesium Ion Vitamin D Metabolic Process Vitamin D Catabolic Process Positive Regulation Of MAPK Cascade Cellular Response To Leptin Stimulus Negative Regulation Of Osteoblast Differentiation Positive Regulation Of DNA-templated Transcription Negative Regulation Of Hormone Secretion Phosphate Ion Homeostasis Calcium Ion Homeostasis ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Vitamin D Cellular Response To Interleukin-6 Cellular Response To Parathyroid Hormone Stimulus Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Response To Sodium Phosphate	Skeletal System Development Proteolysis Cell-cell Signaling Protein Processing Organophosphate Metabolic Process Bone Mineralization Lung Development Biomineral Tissue Development Response To Vitamin D Protein Modification Process Odontogenesis Bone Development Response To Growth Hormone Cellular Response To Vitamin D Cellular Response To Parathyroid Hormone Stimulus Response To Sodium Phosphate Response To Insulin-like Growth Factor Stimulus
Pathways		PI3K Cascade PIP3 activates AKT signaling Signaling by activated point mutants of FGFR1 Signaling by activated point mutants of FGFR3 FGFR4 ligand binding and activation FGFR3c ligand binding and activation FGFR1c ligand binding and activation FGFR1c and Klotho ligand binding and activation FGFR2c ligand binding and activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Signaling by FGFR2 in disease Signaling by FGFR1 in disease Signaling by FGFR3 in disease FGFRL1 modulation of FGFR1 signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Post-translational protein phosphorylation	None
Diseases		Hypophosphatemic rickets; X-Linked dominant hypophosphatemia (XLH); Autosomal dominant hypophosphatemic rickets (ADHR); Autosomal recessive hypophosphatemic rickets (ARHR); Hereditary hypophophatemic rickets with hypercalciuria (HHRH)	Hypophosphatemic rickets; X-Linked dominant hypophosphatemia (XLH); Autosomal dominant hypophosphatemic rickets (ADHR); Autosomal recessive hypophosphatemic rickets (ARHR); Hereditary hypophophatemic rickets with hypercalciuria (HHRH)
GWAS		Colorectal cancer ( 23263487 ) Migraine ( 27182965 ) Phosphorus levels ( 20558539 29403010 )	Anger ( 24489884 ) F-cell distribution in sickle cell anaemia ( 21326311 ) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502 ) Phosphorus levels ( 29403010 ) Tourette syndrome ( 22889924 )
Novel Interactors		1 novel interactors: ERC1	None recorded
Interacting Genes		3 interacting genes: FGFR2 FGFR3 PHEX	1 interacting genes: FGF23
Entrez ID		8074	5251
HPRD ID		05648	02387
Ensembl ID		ENSG00000118972	ENSG00000102174
Uniprot IDs		Q9GZV9	B4DNS0 B4DWG8 P78562
PDB IDs		2P39 5W21 6S22 7YSH 7YSU 7YSW	Not available
GO Terms Enriched among Interactors		Positive Regulation Of Phospholipase Activity Bone Mineralization Fibroblast Growth Factor Receptor Activity Biomineral Tissue Development Positive Regulation Of Lipase Activity Endochondral Bone Growth Bone Growth Fibroblast Growth Factor Binding Bone Morphogenesis Golgi Apparatus Organ Growth Transmembrane Receptor Protein Tyrosine Kinase Activity Fibroblast Growth Factor Receptor Signaling Pathway Bone Development Animal Organ Morphogenesis Cell-cell Signaling Cell Communication Signaling Fibroblast Growth Factor Receptor Signaling Pathway Involved In Negative Regulation Of Apoptotic Process In Bone Marrow Cell Fibroblast Growth Factor Receptor Signaling Pathway Involved In Positive Regulation Of Cell Proliferation In Bone Marrow Odontogenesis Fibroblast Growth Factor Receptor Signaling Pathway Involved In Hemopoiesis Lung Development Positive Regulation Of Hydrolase Activity Tissue Development Protein Tyrosine Kinase Activity Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Mesenchymal Cell Differentiation Involved In Lung Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Mammary Gland Specification Mammary Gland Bud Formation Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Branch Elongation Involved In Salivary Gland Morphogenesis Bone Maturation Skeletal System Development Positive Regulation Of ERK1 And ERK2 Cascade Ventricular Zone Neuroblast Division Prostate Epithelial Cord Elongation Orbitofrontal Cortex Development Response To Insulin-like Growth Factor Stimulus I-kappaB Phosphorylation Receptor Complex Prostate Gland Morphogenesis Mesenchymal Cell Proliferation Involved In Lung Development Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Forebrain Neuroblast Division Branching Morphogenesis Of A Nerve Epidermis Morphogenesis Lacrimal Gland Development Forebrain Ventricular Zone Progenitor Cell Division	Response To Magnesium Ion Vitamin D Metabolic Process Cellular Response To Leptin Stimulus Response To Leptin Cellular Response To Vitamin D Positive Regulation Of Vitamin D 24-hydroxylase Activity Cellular Response To Parathyroid Hormone Stimulus Vitamin D Catabolic Process Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Phosphate Transport Negative Regulation Of Bone Mineralization Response To Parathyroid Hormone Response To Sodium Phosphate Intracellular Phosphate Ion Homeostasis Phosphate Ion Homeostasis Cellular Response To Interleukin-6 Regulation Of Oxidoreductase Activity Type 1 Fibroblast Growth Factor Receptor Binding Response To Interleukin-6 Fibroblast Growth Factor Receptor Binding Steroid Catabolic Process Response To Salt Vitamin Metabolic Process Response To Vitamin D Negative Regulation Of Biomineral Tissue Development Cellular Response To Nutrient Negative Regulation Of Ossification ERK1 And ERK2 Cascade Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Hormone Secretion Response To Vitamin Regulation Of Bone Mineralization Golgi Lumen Neurogenesis Regulation Of Ossification Regulation Of Osteoblast Differentiation Negative Regulation Of Secretion By Cell Response To Nutrient Growth Factor Activity Negative Regulation Of Secretion Positive Regulation Of ERK1 And ERK2 Cascade Calcium Ion Homeostasis Steroid Metabolic Process MAPK Cascade Regulation Of Hormone Secretion Cellular Response To Nutrient Levels Lipid Catabolic Process