FGF14 and H4C7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FGF14	H4C7
Description		fibroblast growth factor 14	H4 clustered histone 7
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Nucleosome Nucleus Chromosome
	Molecular Function	Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Sodium Channel Regulator Activity	DNA Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity
	Biological Process	Signal Transduction JNK Cascade Cell-cell Signaling Nervous System Development Fibroblast Growth Factor Receptor Signaling Pathway Neurogenesis	Nucleosome Assembly
Pathways		Phase 0 - rapid depolarisation
Drugs
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Bone mineral density (hip) ( 30172743) Heel bone mineral density x serum urate levels interaction ( 34046847) Idiopathic downbeat nystagmus ( 32157568) LDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Maximum habitual alcohol consumption ( 31151762) Plasma parathyroid hormone levels ( 30134803) PR interval ( 32439900) Preeclampsia ( 23551011) Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) ( 21130132) Response to protease inhibitor treatment in hepatitis c (bilirubin toxicity) ( 24503447) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931)
Interacting Genes		13 interacting genes: ACACA EHHADH FBXO34 FKBP8 FUNDC2 H4C7 HOXD12 MAOB RTP5 SCN8A SMC1A SYT16 TTPA	13 interacting genes: AGTRAP APOC1 CIDEB EP300 FGF14 FKBP7 KAT2A KAT8 KMT5B KMT5C MAIP1 RHBDD2 TMED8
Entrez ID		2259	8369
HPRD ID		03305	11806
Ensembl ID		ENSG00000102466	ENSG00000275663
Uniprot IDs		A0A7U3JVZ8 A0A9L9PX77 A0A9L9PXK7 Q92915	Q99525
PDB IDs
Enriched GO Terms of Interacting Partners?		Mitochondrial Envelope	Histone Acetyltransferase Complex Protein Propionyltransferase Activity Protein-lysine-acetyltransferase Activity Acetyltransferase Activity Histone H3K18 Acetyltransferase Activity Histone Acetyltransferase Activity Histone H4K20me Methyltransferase Activity Histone H4K20 Monomethyltransferase Activity Histone H4 Methyltransferase Activity Histone H4K20 Methyltransferase Activity Histone H3 Acetyltransferase Activity Internal Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Very-low-density Lipoprotein Particle Assembly Histone H4 Acetyltransferase Activity Peptidyl-lysine Acetylation Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Small Molecule Metabolic Process Chromatin Remodeling Condensed Chromosome, Centromeric Region Negative Regulation Of Gluconeogenesis Chromosome Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains S-adenosyl-L-methionine Binding Positive Regulation Of Adaptive Immune Response Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Acyltransferase Activity Positive Regulation Of Isotype Switching Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Chromatin Organization Protein Acetylation DNA-binding Transcription Factor Binding Chromatin Binding Regulation Of Isotype Switching Regulation Of Triglyceride Metabolic Process Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Immunoglobulin Mediated Immune Response Negative Regulation Of Phosphatidylcholine Catabolic Process Positive Regulation Of Gene Expression, Epigenetic Somitogenesis Peptidyl-lysine Propionylation Segmentation Regulation Of Lymphocyte Activation Swimming Histone Lactyltransferase (CoA-dependent) Activity Gluconeogenesis Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity
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