TMF1 and CMTM5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMF1	CMTM5
Description		TATA element modulatory factor 1	CKLF like MARVEL transmembrane domain containing 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Membrane	Extracellular Space Membrane
	Molecular Function	DNA Binding Transcription Coactivator Activity Protein Binding Nuclear Androgen Receptor Binding	Cytokine Activity Protein Binding
	Biological Process	Acrosome Assembly Positive Regulation Of Cytokine Production Apoptotic Process Spermatid Development Spermatid Nucleus Differentiation Male Gonad Development Negative Regulation Of Gene Expression Flagellated Sperm Motility Androgen Receptor Signaling Pathway Luteinizing Hormone Secretion Leydig Cell Differentiation Defense Response To Bacterium Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Proteasomal Protein Catabolic Process Epithelial Cell Apoptotic Process Negative Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Testosterone Secretion	Chemotaxis Signal Transduction Negative Regulation Of Myoblast Differentiation
Pathways		Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases
GWAS		Meat-related diet ( 32066663) Metabolite levels ( 23823483)
Interacting Genes		9 interacting genes: AR CMTM5 FER GFI1B ITSN2 KAT2B NR3C1 RAB6A SMARCA4	133 interacting genes: AACS ABHD4 ACSF2 ACSM1 ALDH18A1 APOA1 APOA4 APOA5 AQP6 ARFIP1 ARFIP2 ARMC9 BIK BNIP3 CAPNS2 CD160 CD40 CD79A CLDN7 COQ8A CPLX1 CPLX4 CREB3 CYP1A1 DDA1 DHRSX ECPAS ELOVL4 ERGIC3 FAM114A1 FARS2 FCGR2A FCRL3 FERMT2 FFAR2 FNDC9 GAD1 GAD2 GJB1 GLTP GOLGA2P10 GPR42 GPX8 GTF3C1 HNRNPK HSD17B13 JAGN1 JOSD2 KASH5 KCNJ6 KCNK5 KIR3DL3 LEUTX LMNA LMO2 LNX1 LRRC4C LRRC59 MCEE MCEMP1 MCFD2 MEOX2 MFF MGST3 MIEF1 MRM1 MRRF MTERF3 MTIF3 MYG1 NDRG4 NFU1 NTAQ1 PBX3 PCNA PIMREG PITPNC1 PLIN3 PNPO POLL PPIF PPP2R3C PSCA PTPN9 RBFA REEP2 RETREG3 RHBDD1 RMDN2 RNF185 RSRC2 RUSF1 SAR1A SCARA5 SCN3B SDCBP SGCB SH3GL1 SH3GLB1 SHMT2 SLC10A6 SLC18A2 SLC30A4 SLC35H1 SLC7A14 SNX1 SPATA8 SPG21 SSX3 SSX5 STING1 STOM SUCLA2 SYNE4 SYT16 TBRG4 THAP4 TIMM44 TLCD4 TMED8 TMEM139 TMEM14B TMEM35A TMEM80 TMF1 TPD52L3 TSPAN31 TTPA TUBB TUFM VARS2 ZNF391 ZNF599
Entrez ID		7110	116173
HPRD ID		03081	06986
Ensembl ID		ENSG00000144747	ENSG00000166091
Uniprot IDs		P82094 Q6PII6	Q96DZ9
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of MiRNA Transcription Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Estrogen Response Element Binding Protein-containing Complex Seminiferous Tubule Development Negative Regulation Of Transcription By RNA Polymerase II Steroid Binding Chromatin Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nuclear Receptor Activity Regulation Of Gluconeogenesis Positive Regulation Of Gene Expression, Epigenetic Transcription Initiation-coupled Chromatin Remodeling Negative Regulation Of Nucleobase-containing Compound Metabolic Process Prostate Induction Lipid Binding Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Cellular Response To Oxygen-containing Compound RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Male Somatic Sex Determination Cellular Response To Hormone Stimulus Regulation Of Developmental Process Adherens Junction Disassembly Nuclear Glucocorticoid Receptor Activity Chromatin Organization Peptidyl-cysteine Methylation Regulation Of Myoblast Differentiation Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cellular Response To Steroid Hormone Stimulus Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Cell-cell Junction Disassembly Negative Regulation Of RRNA Processing Histone H3K9 Acetyltransferase Activity Clathrin-dependent Synaptic Vesicle Endocytosis DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of RNA Metabolic Process Regulation Of Glucose Metabolic Process Nuclear Receptor-mediated Signaling Pathway Male Gonad Development Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of Integrin Biosynthetic Process	Protein Binding Mitochondrion Mitochondrial Matrix Phosphatidylcholine-sterol O-acyltransferase Activator Activity Identical Protein Binding Lipid Binding Succinate Metabolic Process Mitochondrial Outer Membrane Membrane Endoplasmic Reticulum Membrane Gamma-aminobutyrate Shunt Glutamate Decarboxylase Activity Chylomicron Phospholipid Efflux Small Molecule Biosynthetic Process Low-density Lipoprotein Particle Regulation Of Mitochondrion Organization Regulation Of Release Of Cytochrome C From Mitochondria Endoplasmic Reticulum-autophagosome Adaptor Activity Phospholipid Binding Ligase Activity
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