FCN1 and TSC1

		FCN1	TSC1
Description		ficolin 1	TSC complex subunit 1
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GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Plasma Membrane External Side Of Plasma Membrane Membrane Extracellular Matrix Secretory Granule Lumen Symbiont Cell Surface Ficolin-1-rich Granule Lumen Serine-type Endopeptidase Complex	Nucleus Cytoplasm Lysosome Lysosomal Membrane Lipid Droplet Cytosol Actin Filament Plasma Membrane Cell Cortex Postsynaptic Density Membrane Lamellipodium Protein-containing Complex TSC1-TSC2 Complex Ciliary Basal Body Perinuclear Region Of Cytoplasm Protein Folding Chaperone Complex
	Molecular Function	G Protein-coupled Receptor Binding Antigen Binding Signaling Receptor Binding Protein Binding Carbohydrate Binding Sialic Acid Binding Pattern Recognition Receptor Activity Metal Ion Binding Carbohydrate Derivative Binding	Protein Binding Hsp70 Protein Binding ATPase Inhibitor Activity Protein Folding Chaperone Protein-folding Chaperone Binding Hsp90 Protein Binding
	Biological Process	Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Immune System Process Cell Surface Pattern Recognition Receptor Signaling Pathway Proteolysis Complement Activation G Protein-coupled Receptor Signaling Pathway Opsonization Zymogen Activation Killing Of Cells Of Another Organism Positive Regulation Of Interleukin-8 Production Protein Localization To Cell Surface Recognition Of Apoptotic Cell Innate Immune Response Host-mediated Suppression Of Symbiont Invasion Protein Maturation Positive Regulation Of Opsonization	Kidney Development Neural Tube Closure Regulation Of Cell-matrix Adhesion Adaptive Immune Response Protein Folding Potassium Ion Transport Cell-matrix Adhesion Nervous System Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Associative Learning Adult Locomotory Behavior Cellular Response To Starvation Negative Regulation Of Macroautophagy Hippocampus Development Cerebral Cortex Development Cell Projection Organization Negative Regulation Of TOR Signaling Negative Regulation Of ATP-dependent Activity Response To Insulin Cellular Response To Decreased Oxygen Levels TORC1 Signaling Myelination Memory T Cell Differentiation Negative Regulation Of Cell Size D-glucose Import Synapse Organization Protein Stabilization Regulation Of Stress Fiber Assembly Regulation Of Cell Cycle Positive Regulation Of Focal Adhesion Assembly Cardiac Muscle Cell Differentiation Activation Of GTPase Activity Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling
Pathways		Lectin pathway of complement activation Initial triggering of complement Ficolins bind to repetitive carbohydrate structures on the target cell surface Neutrophil degranulation	Macroautophagy Inhibition of TSC complex formation by PKB Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes TBC/RABGAPs
Drugs
Diseases			Lymphangioleiomyomatosis (LAM) Tuberous sclerosis complex (TSC); Bourneville-Pringle disease
GWAS		Blood protein levels ( 30072576) Trans-epidermal water loss ( 28011148)	Migraine without aura ( 23793025) Psoriasis ( 19169254)
Interacting Genes		2 interacting genes: ELN TGFB1	169 interacting genes: ABI1 ACTN1 ACTN2 AKT1 ANKIB1 ANKRD24 ANKRD35 APPL2 AQP1 ARAF ARID5A ATN1 ATXN1 AURKA AXIN1 BAG3 BCL11A BECN1 BEND5 C1orf94 CALCOCO2 CASC3 CCDC120 CCDC88B CCL28 CCNB1 CCND2 CCNE1 CDK1 CDK4 CDK6 CDKN2A CDKN2B CDR2 CHCHD2 CNIH1 CNTRL CNTROB COG6 CSTF2 CTNNB1 DACH2 DCTN2 DMRT3 DOK5 EIF3A ENKD1 EZR FAM110A FAM222B FBF1 FGFR4 FOXH1 FRS3 GCC1 GEMIN8 GFAP GLIS2 GOLGA2 GPANK1 GPATCH1 HECW1 HGS HNRNPM HOMER3 HOOK2 HOXC8 HR HSH2D ICA1 IGFN1 IKBKB KANSL2 KAT2A KAZN KDM1A KIF1C KIF5A KLC1 KLC4 LATS2 LENG1 LMO2 LRSAM1 LUC7L LZTS2 MAP2K5 MAPK14 MBIP MBP MSANTD3 MSN MT-ND1 MYC MYLIP MYOZ3 NECAB2 NEFL NF2 NINL NKD2 NRBF2 PATL1 PATZ1 PHLDB1 PICK1 PITX1 PLK1 PLK2 POGZ POU6F2 PPFIA2 PPP1R18 PRMT6 RALYL RASSF1 RBPMS RDX RHEB RIN1 RIN3 RUNDC3A SAMD11 SAMD7 SAXO4 SCMH1 SEC31A SELENOW SERTAD1 SH2D2A SHANK1 SHC3 SMG9 SORBS3 SOX4 SPAG5 SPAG8 SUOX TANK TBC1D7 TBX6 TCF7L2 TFAP2D TFIP11 TLE5 TNS2 TRIM3 TRIOBP TSC2 TSGA10IP TSHZ3 USP2-AS1 VENTX VEZF1 VGLL3 VIM VPS37C YPEL3 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZIC1 ZNF417 ZNF423 ZNF587 ZNF765
Entrez ID		2219	7248
HPRD ID		03153	05594
Ensembl ID		ENSG00000085265	ENSG00000165699
Uniprot IDs		O00602	A0A2R8Y5M3 A0A2R8Y5N2 A0A2R8Y5S3 A0A2R8Y6S1 A0A2R8YD74 A0A2R8YFV7 Q32NF0 Q86WV8 Q92574 X5D9D2
PDB IDs		2D39 2JHH 2JHI 2JHK 2JHL 2JHM 2WNP	4Z6Y 5EJC 7DL2 9C9I 9CE3
Enriched GO Terms of Interacting Partners?		Regulation Of Actin Cytoskeleton Organization Aortic Valve Morphogenesis Regulation Of Actin Filament-based Process Extracellular Matrix Assembly Regulation Of Cytoskeleton Organization Heart Valve Morphogenesis Myelination Tube Closure Axon Ensheathment Neural Tube Closure Branch Elongation Involved In Mammary Gland Duct Branching Positive Regulation Of Microglia Differentiation Tube Formation Cellular Response To Acetaldehyde Memory T Cell Differentiation Regulation Of Smooth Muscle Cell Proliferation T Cell Differentiation Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Regulation Of Organelle Organization Positive Regulation Of Primary MiRNA Processing Embryonic Liver Development Extracellular Structure Organization Regulation Of Actin Filament Organization Regulation Of Cell Population Proliferation Regulation Of Cellular Component Size Elastic Fiber Extracellular Matrix Organization System Process Circulatory System Process Negative Regulation Of Hyaluronan Biosynthetic Process Positive Regulation Of MiRNA Processing Myofibroblast Differentiation Mononuclear Cell Differentiation Foam Cell Differentiation Bronchiole Development Lymphocyte Differentiation Macrophage Derived Foam Cell Differentiation Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Adaptive Immune Response Positive Regulation Of Exit From Mitosis Negative Regulation Of Skeletal Muscle Tissue Development Response To Decreased Oxygen Levels Frontal Suture Morphogenesis Mammary Gland Branching Involved In Thelarche Type III Transforming Growth Factor Beta Receptor Binding Tolerance Induction To Self Antigen T Cell Activation Positive Regulation Of Isotype Switching To IgA Isotypes	Cytoskeleton Protein Domain Specific Binding Regulation Of Primary Metabolic Process Cytoplasm Protein Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Protein Localization To Nucleus Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Spindle Pole Microtubule-based Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Microtubule Cytoskeleton Organization Negative Regulation Of Biosynthetic Process Protein Kinase Binding Negative Regulation Of Macromolecule Metabolic Process Identical Protein Binding Cytoskeleton Organization Organelle Organization Negative Regulation Of Metabolic Process G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Intracellular Transport Cell Cycle G1/S Phase Transition Mitotic Cell Cycle Phase Transition Cytoskeletal Protein Binding Cytosol Regulation Of Protein Localization Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Transcription By RNA Polymerase II Microtubule Cytoskeleton Organization Involved In Mitosis MAPK Cascade Cell Cycle Phase Transition Cell Division Positive Regulation Of Early Endosome To Late Endosome Transport Centrosome
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