PLAC9 and RAPGEF5

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		PLAC9	RAPGEF5
Description		placenta associated 9	Rap guanine nucleotide exchange factor 5
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Nucleus Nucleoplasm Plasma Membrane Nuclear Body
	Molecular Function	Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP-dependent Protein Binding
	Biological Process		Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Nervous System Development
Pathways
Drugs
Diseases
GWAS		Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848)	Asthma ( 34103634) Cutaneous malignant melanoma ( 32341527) Depression in smokers ( 30219690) Dialysis-related mortality ( 21546767) Diastolic blood pressure ( 30224653) Gamma glutamyl transferase levels ( 33339817) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) Night sleep phenotypes ( 27126917) Spatial processing ( 31596458) Squamous cell lung carcinoma ( 28604730) Thyroid stimulating hormone levels ( 17903292) Urinary albumin excretion ( 32277301)
Interacting Genes		6 interacting genes: CCDC14 EMILIN1 GPRASP2 RAPGEF5 RNF213 SNAPIN	7 interacting genes: MRAS PLAC9 RAP1A RAP2A RAP2B TMEM253 VANGL1
Entrez ID		219348	9771
HPRD ID		18491	15208
Ensembl ID		ENSG00000189129	ENSG00000136237
Uniprot IDs		Q5JTB5 Q5JTB6	A0A0S2Z561 A8MQ07 Q92565
PDB IDs			1WGY
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Late Endosome To Lysosome Transport Lipid Ubiquitination	Rap Protein Signal Transduction GDP Binding G Protein Activity Small GTPase-mediated Signal Transduction GTPase Activity GTP Binding Bounding Membrane Of Organelle Establishment Of Endothelial Barrier Endothelial Cell Development Intracellular Signaling Cassette Specific Granule Membrane Integrin Alphav-beta8 Complex Response To Antineoplastic Agent Recycling Endosome Membrane Epithelial Cell Development Langerhans Cell Differentiation Recycling Endosome Extracellular Matrix Protein Binding Positive Regulation Of Microvillus Assembly Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Synaptic Vesicle Exocytosis Cytoplasmic Vesicle Membrane
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