AK2 and ABCC6

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		AK2	ABCC6
Name		adenylate kinase 2	ATP binding cassette subfamily C member 6
Structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Sperm Flagellum Extracellular Exosome Sperm Mitochondrial Sheath	Extracellular Region Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane
	Molecular Function	Nucleotide Binding AMP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Phosphotransferase Activity, Phosphate Group As Acceptor Nucleobase-containing Compound Kinase Activity	Nucleotide Binding ATP Binding ABC-type Glutathione S-conjugate Transporter Activity ATP Hydrolysis Activity Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity ATPase-coupled Inorganic Anion Transmembrane Transporter Activity ABC-type Transporter Activity
	Biological Process	Nucleobase-containing Compound Metabolic Process ADP Biosynthetic Process Nucleotide Metabolic Process Nucleoside Monophosphate Metabolic Process Nucleobase-containing Small Molecule Interconversion AMP Metabolic Process ATP Metabolic Process Nucleoside Monophosphate Phosphorylation	Visual Perception Response To Xenobiotic Stimulus Gene Expression ATP Transport Inorganic Diphosphate Transport Intracellular Phosphate Ion Homeostasis Response To Magnesium Ion ATP Metabolic Process Carboxylic Acid Transport Phosphate Ion Homeostasis Calcium Ion Homeostasis Transmembrane Transport Leukotriene Transport Monoatomic Anion Transmembrane Transport Inhibition Of Non-skeletal Tissue Mineralization Response To Sodium Phosphate
Pathways		Interconversion of nucleotide di- and triphosphates	ABC-family proteins mediated transport Defective ABCC6 causes PXE
Drugs		Bis(Adenosine)-5'-Pentaphosphate Imidazole	ATP
Diseases		None	Pseudoxanthoma elasticum, including: Pseudoxanthoma elasticum (PXE); Pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency
GWAS		Gut microbiota (beta diversity) ( 27723756 )	Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Hemoglobin levels ( 32327693 ) Multiple myeloma (survival) ( 26198393 ) Red blood cell count ( 32888494 )
Interacting Genes		4 interacting genes: ABCC5 ABCC6 SHBG TRIM54	5 interacting genes: A1BG AK2 CRYL1 FURIN NR4A1
Entrez ID		204	368
HPRD ID		00047	04453
Ensembl ID		ENSG00000004455	ENSG00000091262
Uniprot IDs		A0A140VK93 F8VY04 F8W1A4 G3V213 P54819	O95255
PDB IDs		2C9Y	6BZR 6BZS 6NLO 6P7F
GO Terms Enriched among Interactors		ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Adenine Nucleotide Transport Purine Nucleotide Transport ATPase-coupled Transmembrane Transporter Activity Nucleotide Transport ABC-type Transporter Activity Carbohydrate Derivative Transport Carbohydrate Derivative Transmembrane Transporter Activity CGMP Transport Macromolecule Transmembrane Transporter Activity Monoatomic Anion Transmembrane Transport Organophosphate Ester Transport Monoatomic Anion Transport CAMP Transport Heme Transmembrane Transport Folate Transmembrane Transport Purine Nucleotide Transmembrane Transporter Activity Inorganic Diphosphate Transport Nucleobase-containing Compound Transport Inhibition Of Non-skeletal Tissue Mineralization Hyaluronan Biosynthetic Process Basolateral Plasma Membrane Androgen Binding Organic Acid Transport Carboxylic Acid Transport Leukotriene Transport Glutathione Transmembrane Transporter Activity Heme Transmembrane Transporter Activity Heme Transport ABC-type Glutathione S-conjugate Transporter Activity Response To Sodium Phosphate Intracellular Phosphate Ion Homeostasis Folic Acid Transport Cyclic Nucleotide Transport Glutathione Transmembrane Transport Organic Anion Transport Efflux Transmembrane Transporter Activity Glutathione Transport Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane ATP Hydrolysis Activity Xenobiotic Export From Cell ABC-type Xenobiotic Transporter Activity Oligopeptide Transmembrane Transport Xenobiotic Transmembrane Transport Response To Magnesium Ion Oligopeptide Transport Iron Ion Transmembrane Transport Glycosaminoglycan Biosynthetic Process Vitamin Transmembrane Transport Organic Anion Transmembrane Transporter Activity	Extracellular Exosome ADP Biosynthetic Process Sperm Mitochondrial Sheath Non-canonical Inflammasome Complex Assembly Detection Of Lipopolysaccharide Cellular Response To Corticotropin-releasing Hormone Stimulus Viral Translation Negative Regulation Of Nerve Growth Factor Production Viral Life Cycle Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Dibasic Protein Processing Cytokine Precursor Processing Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Zymogen Inhibition Negative Regulation Of Transforming Growth Factor Beta1 Production Nerve Growth Factor Production Nerve Growth Factor Binding Negative Regulation Of Receptor Catabolic Process Negative Regulation Of Neurotrophin Production L-gulonate 3-dehydrogenase Activity D-glucuronate Catabolic Process D-glucuronate Catabolic Process To D-xylulose 5-phosphate Nucleobase-containing Small Molecule Interconversion Phosphotransferase Activity, Phosphate Group As Acceptor Nucleoside Monophosphate Phosphorylation Nucleobase-containing Compound Kinase Activity AMP Kinase Activity Heparan Sulfate Binding Signal Peptide Processing Ribonucleoside Diphosphate Biosynthetic Process Endothelial Cell Chemotaxis Regulation Of Type B Pancreatic Cell Proliferation Negative Regulation Of Transforming Growth Factor Beta Production Nucleoside Diphosphate Biosynthetic Process Detection Of Molecule Of Bacterial Origin Nuclear Glucocorticoid Receptor Binding Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of Membrane Protein Ectodomain Proteolysis Trans-Golgi Network Transport Vesicle Endopeptidase Activator Activity NAD+ Binding Regulation Of Viral Entry Into Host Cell Negative Regulation Of Protein Processing Blastocyst Formation AMP Metabolic Process Peptide Biosynthetic Process Negative Regulation Of Protein Maturation Cell Migration Involved In Sprouting Angiogenesis