ABCC6 and A1BG

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		ABCC6	A1BG
Name		ATP binding cassette subfamily C member 6	alpha-1-B glycoprotein
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane	Extracellular Region Extracellular Space Plasma Membrane Platelet Alpha Granule Lumen Secretory Granule Lumen Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen
	Molecular Function	Nucleotide Binding ATP Binding ABC-type Glutathione S-conjugate Transporter Activity ATP Hydrolysis Activity Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity ATPase-coupled Inorganic Anion Transmembrane Transporter Activity ABC-type Transporter Activity	None
	Biological Process	Visual Perception Response To Xenobiotic Stimulus Gene Expression ATP Transport Inorganic Diphosphate Transport Intracellular Phosphate Ion Homeostasis Response To Magnesium Ion ATP Metabolic Process Carboxylic Acid Transport Phosphate Ion Homeostasis Calcium Ion Homeostasis Transmembrane Transport Leukotriene Transport Monoatomic Anion Transmembrane Transport Inhibition Of Non-skeletal Tissue Mineralization Response To Sodium Phosphate	Immune Response-regulating Signaling Pathway
Pathways		ABC-family proteins mediated transport Defective ABCC6 causes PXE	Platelet degranulation Neutrophil degranulation
Drugs		ATP	Zinc Copper Zinc acetate
Diseases		Pseudoxanthoma elasticum, including: Pseudoxanthoma elasticum (PXE); Pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency	None
GWAS		Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Hemoglobin levels ( 32327693 ) Multiple myeloma (survival) ( 26198393 ) Red blood cell count ( 32888494 )	No GWAS studies recorded
Interacting Genes		5 interacting genes: A1BG AK2 CRYL1 FURIN NR4A1	13 interacting genes: ABCC6 ANXA7 CDKN1A CRISP3 GRB7 HSP90AA1 MTX1 PRDX4 SAMM50 SETD7 SMN1 SNCA TK1
Entrez ID		368	1
HPRD ID		04453	00726
Ensembl ID		ENSG00000091262	ENSG00000121410
Uniprot IDs		O95255	P04217
PDB IDs		6BZR 6BZS 6NLO 6P7F	Not available
GO Terms Enriched among Interactors		Extracellular Exosome ADP Biosynthetic Process Sperm Mitochondrial Sheath Non-canonical Inflammasome Complex Assembly Detection Of Lipopolysaccharide Cellular Response To Corticotropin-releasing Hormone Stimulus Viral Translation Negative Regulation Of Nerve Growth Factor Production Viral Life Cycle Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Dibasic Protein Processing Cytokine Precursor Processing Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Zymogen Inhibition Negative Regulation Of Transforming Growth Factor Beta1 Production Nerve Growth Factor Production Nerve Growth Factor Binding Negative Regulation Of Receptor Catabolic Process Negative Regulation Of Neurotrophin Production L-gulonate 3-dehydrogenase Activity D-glucuronate Catabolic Process D-glucuronate Catabolic Process To D-xylulose 5-phosphate Nucleobase-containing Small Molecule Interconversion Phosphotransferase Activity, Phosphate Group As Acceptor Nucleoside Monophosphate Phosphorylation Nucleobase-containing Compound Kinase Activity AMP Kinase Activity Heparan Sulfate Binding Signal Peptide Processing Ribonucleoside Diphosphate Biosynthetic Process Endothelial Cell Chemotaxis Regulation Of Type B Pancreatic Cell Proliferation Negative Regulation Of Transforming Growth Factor Beta Production Nucleoside Diphosphate Biosynthetic Process Detection Of Molecule Of Bacterial Origin Nuclear Glucocorticoid Receptor Binding Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of Membrane Protein Ectodomain Proteolysis Trans-Golgi Network Transport Vesicle Endopeptidase Activator Activity NAD+ Binding Regulation Of Viral Entry Into Host Cell Negative Regulation Of Protein Processing Blastocyst Formation AMP Metabolic Process Peptide Biosynthetic Process Negative Regulation Of Protein Maturation Cell Migration Involved In Sprouting Angiogenesis	Establishment Of Protein Localization To Mitochondrion SAM Complex MIB Complex Protein Insertion Into Mitochondrial Outer Membrane Response To Magnesium Ion Mitochondrial Membrane Organization Establishment Of Protein Localization To Organelle Protein Import Into Mitochondrial Matrix Protein Insertion Into Mitochondrial Membrane Establishment Of Protein Localization To Mitochondrial Membrane Protein Kinase Inhibitor Activity Protein Sequestering Activity Response To Cocaine Protein Localization To Mitochondrion Tau Protein Binding Inner Mitochondrial Membrane Organization Mitochondrial Outer Membrane CTP Binding DATP Binding Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Mitochondrion Organization Membrane Organization Response To Xenobiotic Stimulus Positive Regulation Of Reactive Oxygen Species Metabolic Process PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration Identical Protein Binding Protein Transmembrane Transport Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Protein Insertion Into Membrane Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Thymidine Kinase Activity Response To Metal Ion Regulation Of DNA Biosynthetic Process Response To Alkaloid DNA Biosynthetic Process Rho GDP-dissociation Inhibitor Binding Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Protein Tetramerization Negative Regulation Of Chaperone-mediated Autophagy DNA Synthesis Involved In Mitotic DNA Replication