ABCC6 and CRYL1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ABCC6	CRYL1
Gene Name		ATP-binding cassette, sub-family C (CFTR/MRP), member 6	crystallin, lambda 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane	Nucleus Nucleolus Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Transporter Activity ATP Binding ATPase Activity, Coupled To Transmembrane Movement Of Substances	3-hydroxyacyl-CoA Dehydrogenase Activity Protein Homodimerization Activity L-gulonate 3-dehydrogenase Activity NAD+ Binding
	Biological Process	Transport Visual Perception Response To Drug Transmembrane Transport	Fatty Acid Metabolic Process Oxidation-reduction Process
Pathways		ABC-family proteins mediated transport
Drugs
Diseases
GWAS			Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) ( 23648065) Obesity-related traits ( 23251661)
Protein-Protein Interactions		5 interactors: A1BG AK2 CRYL1 FURIN NR4A1	1 interactors: ABCC6
Entrez ID		368	51084
HPRD ID		04453	16762
Ensembl ID		ENSG00000091262	ENSG00000165475
Uniprot IDs		A2RRN8 O95255	Q9Y2S2
PDB IDs			3F3S
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nerve Growth Factor Production Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Receptor Catabolic Process Nerve Growth Factor Processing Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Production ADP Biosynthetic Process Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity DATP Metabolic Process Negative Regulation Of Proteolysis Nucleoside Diphosphate Biosynthetic Process Viral Protein Processing Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing ADP Metabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Peptidyl-glutamic Acid Carboxylation Regulation Of Peptidase Activity AMP Metabolic Process Endothelial Cell Chemotaxis Response To Thyroid Hormone Nucleobase-containing Small Molecule Interconversion Signal Peptide Processing Cell Migration Involved In Sprouting Angiogenesis Virion Assembly Deoxyribonucleoside Triphosphate Metabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Peptide Biosynthetic Process Blood Vessel Endothelial Cell Migration Regulation Of Proteolysis Peptide Hormone Processing Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Catalytic Activity Response To Organic Substance
Tagcloud ?		alpl bmp2 bmps calcification comes ectonucleotides elasticum enpp1 extrapolate localizing mineralisation mineralization msx2 multisystem neovascularisation osteoinductive papular perturbed pseudoxanthoma pxe runx2 smad2 smads stains subretinal tgfbeta tgfbeta1 tgfbetas whiskers
Tagcloud (Difference) ?		alpl bmp2 bmps calcification comes ectonucleotides elasticum enpp1 extrapolate localizing mineralisation mineralization msx2 multisystem neovascularisation osteoinductive papular perturbed pseudoxanthoma pxe runx2 smad2 smads stains subretinal tgfbeta tgfbeta1 tgfbetas whiskers
Tagcloud (Intersection) ?