ABCC6 and CRYL1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ABCC6	CRYL1
Description		ATP binding cassette subfamily C member 6	crystallin lambda 1
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GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Nucleotide Binding ATP Binding ABC-type Glutathione S-conjugate Transporter Activity ATP Hydrolysis Activity Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity ATPase-coupled Inorganic Anion Transmembrane Transporter Activity ABC-type Transporter Activity	Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Protein Homodimerization Activity L-gulonate 3-dehydrogenase Activity NAD+ Binding
	Biological Process	Visual Perception Response To Xenobiotic Stimulus Gene Expression ATP Transport Inorganic Diphosphate Transport Intracellular Phosphate Ion Homeostasis Response To Magnesium Ion ATP Metabolic Process Carboxylic Acid Transport Phosphate Ion Homeostasis Calcium Ion Homeostasis Transmembrane Transport Leukotriene Transport Monoatomic Anion Transmembrane Transport Inhibition Of Non-skeletal Tissue Mineralization Response To Sodium Phosphate	Fatty Acid Metabolic Process D-glucuronate Catabolic Process To D-xylulose 5-phosphate
Pathways		ABC-family proteins mediated transport Defective ABCC6 causes PXE	Formation of xylulose-5-phosphate
Drugs		ATP
Diseases		Pseudoxanthoma elasticum, including: Pseudoxanthoma elasticum (PXE); Pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Multiple myeloma (survival) ( 26198393) Red blood cell count ( 32888494)	Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) ( 23648065) Obesity-related traits ( 23251661)
Interacting Genes		5 interacting genes: A1BG AK2 CRYL1 FURIN NR4A1	2 interacting genes: ABCC6 BTG3
Entrez ID		368	51084
HPRD ID		04453	16762
Ensembl ID		ENSG00000091262	ENSG00000165475
Uniprot IDs		O95255	A0A2R8Y4K2 Q9Y2S2 V9HWG2
PDB IDs		6BZR 6BZS 6NLO 6P7F	3F3S
Enriched GO Terms of Interacting Partners?		Extracellular Exosome ADP Biosynthetic Process Sperm Mitochondrial Sheath Non-canonical Inflammasome Complex Assembly Detection Of Lipopolysaccharide Cellular Response To Corticotropin-releasing Hormone Stimulus Viral Translation Negative Regulation Of Nerve Growth Factor Production Viral Life Cycle Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Dibasic Protein Processing Cytokine Precursor Processing Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Zymogen Inhibition Negative Regulation Of Transforming Growth Factor Beta1 Production Nerve Growth Factor Production Nerve Growth Factor Binding Negative Regulation Of Receptor Catabolic Process Negative Regulation Of Neurotrophin Production L-gulonate 3-dehydrogenase Activity D-glucuronate Catabolic Process D-glucuronate Catabolic Process To D-xylulose 5-phosphate Nucleobase-containing Small Molecule Interconversion Phosphotransferase Activity, Phosphate Group As Acceptor Nucleoside Monophosphate Phosphorylation Nucleobase-containing Compound Kinase Activity AMP Kinase Activity Heparan Sulfate Binding Signal Peptide Processing Ribonucleoside Diphosphate Biosynthetic Process Endothelial Cell Chemotaxis Regulation Of Type B Pancreatic Cell Proliferation Negative Regulation Of Transforming Growth Factor Beta Production Nucleoside Diphosphate Biosynthetic Process Detection Of Molecule Of Bacterial Origin Nuclear Glucocorticoid Receptor Binding Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of Membrane Protein Ectodomain Proteolysis Trans-Golgi Network Transport Vesicle Endopeptidase Activator Activity NAD+ Binding Regulation Of Viral Entry Into Host Cell Negative Regulation Of Protein Processing Blastocyst Formation AMP Metabolic Process Peptide Biosynthetic Process Negative Regulation Of Protein Maturation Cell Migration Involved In Sprouting Angiogenesis	Inorganic Diphosphate Transport Leukotriene Transport ABC-type Glutathione S-conjugate Transporter Activity Response To Sodium Phosphate Inhibition Of Non-skeletal Tissue Mineralization Intracellular Phosphate Ion Homeostasis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Response To Magnesium Ion ATP Transport Phosphate Ion Homeostasis Response To Salt Adenine Nucleotide Transport Purine Nucleotide Transport ATPase-coupled Transmembrane Transporter Activity Nucleotide Transport ABC-type Transporter Activity Basal Plasma Membrane Carbohydrate Derivative Transport
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