VMA21 and ORMDL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		VMA21	ORMDL1
Description		vacuolar ATPase assembly factor VMA21	ORMDL sphingolipid biosynthesis regulator 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane ER To Golgi Transport Vesicle Membrane Membrane Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Serine Palmitoyltransferase Complex
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Lysosomal Lumen Acidification Vacuolar Proton-transporting V-type ATPase Complex Assembly	Sphingolipid Metabolic Process Ceramide Metabolic Process Sphingomyelin Biosynthetic Process Sphingolipid Biosynthetic Process Myelination Motor Behavior Regulation Of Sphingolipid Biosynthetic Process Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Regulation Of Ceramide Biosynthetic Process
Pathways			Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS			Bilirubin levels ( 20639394) Ferritin levels ( 25162662)
Interacting Genes		29 interacting genes: ABHD16A ADAM33 AQP6 ARL6IP1 ATP13A1 ATP6V0B BNIP1 CDIPT CLEC12B DAGLA HMOX2 INSIG2 LHFPL5 LYPD6B NINJ2 NIPAL3 ORMDL1 PLLP RTP2 SCD SLC25A46 SLC35E4 TECR THSD7A TMEM107 TMEM60 VAMP2 YIF1A YIPF1	42 interacting genes: APP AQP6 ARL13B ASGR2 BIK CD79A COQ9 CPLX4 CREB3 CREB3L1 EBAG9 EBP EHHADH ERGIC3 FAM209A GPR152 HSD17B11 KCNK4 LMNA LNX1 MTIF3 PCNX2 PGRMC2 REEP4 SAR1A SCN3B SLC10A1 SLC10A6 SLC18A1 SLC30A8 SLC35H1 SLC71A2 STOM TIMMDC1 TLCD4 TMEM143 TMEM14B TMEM35A TMEM52B VMA21 ZDHHC15 ZFYVE27
Entrez ID		203547	94101
HPRD ID		18578	15092
Ensembl ID		ENSG00000160131	ENSG00000128699
Uniprot IDs		Q3ZAQ7	Q9P0S3
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Membrane Organization Endoplasmic Reticulum Monoacylglycerol Lipase Activity Lipid Biosynthetic Process Acylglycerol Metabolic Process Neutral Lipid Metabolic Process Establishment Of Protein Localization To Membrane Craniofacial Suture Morphogenesis Myelination Axon Ensheathment Acylglycerol Catabolic Process Nitrate Transmembrane Transporter Activity SNAP Receptor Activity Lipid Metabolic Process Glycerolipid Metabolic Process Monounsaturated Fatty Acid Biosynthetic Process CDP-diacylglycerol-inositol 3-phosphatidyltransferase Activity Extraction Of Mislocalized Protein From ER Membrane ABC-type Manganese Transporter Activity Membrane Protein Dislocase Activity	Membrane Endoplasmic Reticulum Protein Binding Bile Acid:sodium Symporter Activity Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Endoplasmic Reticulum Membrane
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