HTRA4 and GTF2IRD1

Number of citations of the paper that reports this interaction (PubMedID 26275350)
0

Data Source:
BioGRID (two hybrid)

		HTRA4	GTF2IRD1
Description		HtrA serine peptidase 4	GTF2I repeat domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Nucleus Nucleoplasm Cytosol
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Identical Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Proteolysis Programmed Cell Death Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Apoptotic Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Transition Between Slow And Fast Fiber
Pathways
Drugs
Diseases
GWAS			Age at suicide ( 31476763) Aluminium levels ( 26025379) General factor of neuroticism ( 30867560) Neuroticism ( 29255261) Rheumatoid arthritis ( 32723749) Severe influenza A (H1N1) infection ( 26379185) Sjögren's syndrome ( 24097066) Systemic lupus erythematosus ( 26663301 28714469) Triglyceride levels ( 32203549)
Interacting Genes		1 interacting genes: GTF2IRD1	24 interacting genes: ALMS1 ATP2C1 CDK20 DCAF6 EXOSC4 GORASP2 HDAC3 HTRA4 KPNA1 KPNA2 KPNA3 KPNA4 MRFAP1L1 PIAS1 PIAS2 PIP4P2 PKP1 PKP2 SELENOS SMAD3 SPTLC1 UBC USP20 ZMYM5
Entrez ID		203100	9569
HPRD ID		08818	08379
Ensembl ID		ENSG00000169495	ENSG00000006704
Uniprot IDs		P83105	E9PFE2 Q9UHL9
PDB IDs			2D99 2DN5 2DZQ 2DZR
Enriched GO Terms of Interacting Partners?		Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Positive Regulation Of Macrophage Fusion Transition Between Slow And Fast Fiber Monocyte Activation Positive Regulation Of Keratinocyte Migration Response To Manganese Ion Membrane Protein Intracellular Domain Proteolysis Cell-cell Adhesion Mediated By Integrin Regulation Of Skeletal Muscle Adaptation Positive Regulation Of Membrane Protein Ectodomain Proteolysis Amyloid Precursor Protein Catabolic Process Membrane Protein Ectodomain Proteolysis Positive Regulation Of Cell Adhesion Mediated By Integrin Laminin Binding Amyloid Precursor Protein Metabolic Process Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Cell Adhesion Mediated By Integrin Membrane Protein Proteolysis Positive Regulation Of Epithelial Cell Migration Protein Kinase C Binding Regulation Of Cell Adhesion Mediated By Integrin	NLS-dependent Protein Nuclear Import Complex Nuclear Import Signal Receptor Activity Nuclear Localization Sequence Binding NLS-bearing Protein Import Into Nucleus Viral Penetration Into Host Nucleus Protein Import Into Nucleus Import Into Nucleus Intermediate Filament Binding Intracellular Transport Of Virus Intermediate Filament Bundle Assembly Desmosome Assembly Nucleoplasm Host Cell Protein Localization To Nucleus SUMO Ligase Activity Positive Regulation Of Protein Localization To Cell Periphery Desmosome Organization Nuclear Pore Ubiquitin-specific Protease Binding Positive Regulation Of Protein Localization SUMO Transferase Activity Nuclear Transport Nucleocytoplasmic Transport SMAD Protein Signal Transduction Desmosome Ubiquitin Protein Ligase Binding Intracellular Protein Transport Cellular Localization Collagen Type XV Trimer Establishment Of Protein Localization To Organelle Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Positive Regulation Of Protein Import Into Nucleus Regulation Of Protein Localization To Cell Periphery Maintenance Of Protein Localization At Cell Tip Positive Regulation Of Ferroptosis
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