TSNARE1 and SEC11C

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TSNARE1	SEC11C
Description		t-SNARE domain containing 1	SEC11 homolog C, signal peptidase complex subunit
Image		No pdb structure
GO Annotations	Cellular Component	Synaptic Vesicle Endomembrane System Membrane SNARE Complex	Endoplasmic Reticulum Signal Peptidase Complex Endoplasmic Reticulum Membrane Membrane
	Molecular Function	SNARE Binding SNAP Receptor Activity	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity
	Biological Process	Intracellular Protein Transport Vesicle Fusion Vesicle-mediated Transport Vesicle Docking	Signal Peptide Processing Proteolysis
Pathways			SRP-dependent cotranslational protein targeting to membrane Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Maturation of hRSV A proteins
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adventurousness ( 30643258) Age at first sexual intercourse ( 34211149) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anxiety ( 33859377) Anxiety/tension (special factor of neuroticism) ( 30867560) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder x sex interaction ( 34099189) Body size at age 10 ( 32376654) Broad depression or schizophrenia ( 30626913) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cognitive decline rate in late mild cognitive impairment ( 26252872) Feeling nervous ( 29500382) Feeling tense ( 29500382) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Intelligence (MTAG) ( 29326435) Mental health study participation (completed survey) ( 31263887) Monoclonal gammopathy of undetermined significance ( 30737484) Schizophrenia ( 25056061 28991256 29483656 23974872 30285260) Systolic blood pressure ( 30578418 30224653)	Alzheimer's disease (age of onset) ( 22005931) Chronotype ( 30696823) Morning person ( 30696823)
Interacting Genes		27 interacting genes: AQP6 CD79A CNIH4 CYB561 DYNLL1 EBP ELOVL4 ELOVL5 GPR152 JAGN1 LEPROTL1 LMNA REEP4 RETREG3 SEC11C SLC10A6 SLC35H1 SLC71A2 STX1A TM4SF19 TMEM229B TMEM51 TMEM86B TMX2 VEZT YIPF4 ZDHHC15	23 interacting genes: BTN2A2 C2 CADM3 GLP1R HMOX1 MFF PLPP6 PRSS23 RTP2 SCD SELENOM SERP1 STX12 TMEM128 TMEM243 TMEM254 TMEM42 TREX1 TSNARE1 UBE2J1 VAMP1 VAMP4 VAPA
Entrez ID		203062	90701
HPRD ID		08708	15310
Ensembl ID		ENSG00000171045	ENSG00000166562
Uniprot IDs		A0AVG3 E5RHT3 Q6P186 Q96NA8	K7EJQ7 Q9BY50
PDB IDs			7P2Q
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Fatty Acid Elongation, Saturated Fatty Acid Endoplasmic Reticulum Organization Very Long-chain Fatty Acid Biosynthetic Process Fatty Acid Elongation Long-chain Fatty-acyl-CoA Biosynthetic Process Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Nuclear Envelope Organization Long-chain Fatty-acyl-CoA Metabolic Process Myosin Binding Fatty-acyl-CoA Biosynthetic Process	SNARE Complex Membrane SNAP Receptor Activity Organelle Fusion Vesicle Organization Membrane Fusion SNARE Complex Assembly Establishment Of Protein Localization Organelle Localization By Membrane Tethering Membrane Docking Hormone Secretion Hormone Transport Endoplasmic Reticulum Membrane Vesicle Fusion Organelle Membrane Fusion Endoplasmic Reticulum Synaptic Vesicle Signal Release Glucagon-like Peptide 1 Receptor Activity Monounsaturated Fatty Acid Biosynthetic Process Organic Hydroxy Compound Transport Immune Complex Formation Adenyl Deoxyribonucleotide Binding Immune Response In Brain Or Nervous System Isoprenoid Diphosphate Phosphatase Activity Farnesyl Diphosphate Catabolic Process Geranylgeranyl Diphosphate Catabolic Process
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