SEC11C and CADM3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SEC11C	CADM3
Description		SEC11 homolog C, signal peptidase complex subunit	cell adhesion molecule 3
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GO Annotations	Cellular Component	Endoplasmic Reticulum Signal Peptidase Complex Endoplasmic Reticulum Membrane Membrane	Plasma Membrane Cell-cell Junction Membrane Presynaptic Membrane Anchoring Junction
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity	Protein Binding Protein Homodimerization Activity
	Biological Process	Signal Peptide Processing Proteolysis	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
Pathways		SRP-dependent cotranslational protein targeting to membrane Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Maturation of hRSV A proteins	Adherens junctions interactions Nectin/Necl trans heterodimerization
Drugs
Diseases
GWAS		Alzheimer's disease (age of onset) ( 22005931) Chronotype ( 30696823) Morning person ( 30696823)	Allergic disease (asthma, hay fever or eczema) ( 29679657) Asthma ( 32296059) Bipolar disorder and eating disorder ( 26433762) Inflammatory biomarkers ( 22291609) Neutrophil count in HIV-infection ( 25884002)
Interacting Genes		23 interacting genes: BTN2A2 C2 CADM3 GLP1R HMOX1 MFF PLPP6 PRSS23 RTP2 SCD SELENOM SERP1 STX12 TMEM128 TMEM243 TMEM254 TMEM42 TREX1 TSNARE1 UBE2J1 VAMP1 VAMP4 VAPA	1 interacting genes: SEC11C
Entrez ID		90701	57863
HPRD ID		15310	13733
Ensembl ID		ENSG00000166562	ENSG00000162706
Uniprot IDs		K7EJQ7 Q9BY50	Q8N126
PDB IDs		7P2Q	1Z9M
Enriched GO Terms of Interacting Partners?		SNARE Complex Membrane SNAP Receptor Activity Organelle Fusion Vesicle Organization Membrane Fusion SNARE Complex Assembly Establishment Of Protein Localization Organelle Localization By Membrane Tethering Membrane Docking Hormone Secretion Hormone Transport Endoplasmic Reticulum Membrane Vesicle Fusion Organelle Membrane Fusion Endoplasmic Reticulum Synaptic Vesicle Signal Release Glucagon-like Peptide 1 Receptor Activity Monounsaturated Fatty Acid Biosynthetic Process Organic Hydroxy Compound Transport Immune Complex Formation Adenyl Deoxyribonucleotide Binding Immune Response In Brain Or Nervous System Isoprenoid Diphosphate Phosphatase Activity Farnesyl Diphosphate Catabolic Process Geranylgeranyl Diphosphate Catabolic Process	Interleukin-12-mediated Signaling Pathway Signal Peptidase Complex Signal Peptide Processing Response To Interleukin-6 T-helper 1 Cell Differentiation
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