OSTCP1 and EDA

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		OSTCP1	EDA
Description		oligosaccharyltransferase complex subunit pseudogene 1	ectodysplasin A
Image		No pdb structure
GO Annotations	Cellular Component		Extracellular Region Collagen Trimer Extracellular Space Endoplasmic Reticulum Membrane Lipid Droplet Cytoskeleton Plasma Membrane Membrane Apical Part Of Cell
	Molecular Function		Signaling Receptor Binding Death Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Death Receptor Agonist Activity
	Biological Process		Hair Follicle Development Immune Response Cell-matrix Adhesion Cell Surface Receptor Signaling Pathway Gene Expression Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Cell Differentiation Odontogenesis Of Dentin-containing Tooth Odontogenesis Positive Regulation Of Canonical NF-kappaB Signal Transduction Pigmentation Skin Development Canonical Wnt Signaling Pathway Salivary Gland Cavitation Hair Follicle Placode Formation Trachea Gland Development Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways			TNFs bind their physiological receptors
Drugs
Diseases			Ectodermal dysplasia, including: Ectodermal dysplasia, anhidrotic; Ectodermal dysplasia, hypohidrotic Tooth agenesis; Hypodontia
GWAS		Refractive error ( 32231278)	Male-pattern baldness ( 30573740) Metabolite levels ( 23823483) Monobrow ( 27182965) Primary tooth development (number of teeth) ( 20195514 23704328) Primary tooth development (time to first tooth eruption) ( 20195514 23704328) Tooth agenesis (maxillary lateral incisors) ( 29364747)
Interacting Genes		4 interacting genes: APP EDA LMNA SYNE4	23 interacting genes: ATP6V0C CTXN3 CYB561 DOLK EDA2R EDAR EMP1 EMP3 FURIN GIMAP5 LEPROTL1 LPAR3 MAL MS4A13 OSTC OSTCP1 PLN PMP22 SEC22A SLC38A7 TMEM42 TMEM50B TMEM60
Entrez ID		202459	1896
HPRD ID		14130	02347
Ensembl ID		ENSG00000293101	ENSG00000158813
Uniprot IDs			A0A0U5J797 Q92838
PDB IDs			1RJ7 1RJ8 7X9G
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Regulation Of Protein Localization To Nucleus Growth Factor Receptor Binding Main Axon Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Hair Follicle Placode Formation Trachea Gland Development Salivary Gland Cavitation Death Receptor Agonist Activity Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Lamin Filament DNA Double-strand Break Attachment To Nuclear Envelope Nuclear Pore Localization Structural Constituent Of Nuclear Lamina Establishment Or Maintenance Of Cell Polarity Nuclear Envelope Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity	Bleb Assembly Membrane Lysosomal Membrane Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Endosome Transport Via Multivesicular Body Sorting Pathway Late Endosome To Vacuole Transport Epidermis Development Plasma Membrane Bounded Cell Projection Assembly Cell Projection Assembly Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Circadian Sleep/wake Cycle, Sleep Phospholamban Complex Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Dolichol Kinase Activity L-asparagine:sodium Symporter Activity L-glutamine:sodium Symporter Activity
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