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PDE12 and UBC
Number of citations of the paper that reports this interaction (PMID
21906983
)
158
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology)
PDE12
UBC
Gene Name
phosphodiesterase 12
ubiquitin C
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Mitochondrial Matrix
Nucleoplasm
Cytosol
Plasma Membrane
Endosome Membrane
Endocytic Vesicle Membrane
Extracellular Vesicular Exosome
Molecular Function
Poly(A)-specific Ribonuclease Activity
Metal Ion Binding
Protease Binding
Protein Binding
Poly(A) RNA Binding
Biological Process
MRNA Processing
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Activation Of MAPK Activity
Protein Polyubiquitination
Mitotic Cell Cycle
Toll-like Receptor Signaling Pathway
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Carbohydrate Metabolic Process
Glycogen Biosynthetic Process
Glucose Metabolic Process
DNA Repair
Transcription, DNA-templated
Transcription Initiation From RNA Polymerase II Promoter
Apoptotic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Epidermal Growth Factor Receptor Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
Notch Signaling Pathway
Notch Receptor Processing
I-kappaB Kinase/NF-kappaB Signaling
JNK Cascade
Circadian Rhythm
Fibroblast Growth Factor Receptor Signaling Pathway
Pathogenesis
Gene Expression
Viral Process
Endosomal Transport
Viral Life Cycle
Virion Assembly
Viral Protein Processing
Cytokine-mediated Signaling Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Type I Interferon Production
Negative Regulation Of Type I Interferon Production
Positive Regulation Of Type I Interferon Production
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Ion Transmembrane Transport
TRIF-dependent Toll-like Receptor Signaling Pathway
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Small Molecule Metabolic Process
Innate Immune Response
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Neurotrophin TRK Receptor Signaling Pathway
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Stress-activated MAPK Cascade
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Transmembrane Transport
Membrane Organization
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Cellular Response To Hypoxia
Intracellular Transport Of Virus
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions
1 interactors:
UBC
491 interactors:
ABL1
ADH7
AMPH
ANAPC1
ANAPC11
ANAPC7
ANGPTL3
ANKRD30A
ANKS1A
ANKS1B
APC2
APOC3
ARNTL2
ASB11
ASB2
ASMTL
ATG16L1
ATXN3
BARX1
BCAS2
BCL10
BIN1
BIRC2
BIRC6
BIRC7
BMS1
BRCA1
BRCC3
BRE
BRSK1
BTD
C3orf17
C8orf34
CALCOCO2
CBL
CBLB
CBLC
CBR1
CBR3
CCDC149
CCDC50
CCNB1IP1
CCNK
CCT4
CD2AP
CDH22
CDKN1A
CDY1B
CENPE
CEP164
CEP192
CEP83
CFTR
CHCHD2
CHERP
CHGA
CITED2
CKMT1A
CLN8
CNOT4
CNTLN
CNTRL
CP
CPB2
CRTC2
CSMD3
CTRC
CUEDC2
CUL4B
CUL9
CYP3A4
DAZAP2
DDX42
DDX58
DECR2
DENR
DHFR
DLGAP4
DMBX1
DMRT2
DNAH7
DNASE2B
DNHD1
DOCK6
DPP9
DYNC1I1
DYRK2
DZIP3
ECE2
EFS
EHMT1
EIF3C
EIF3F
ELK1
ELL
ENPP7
EPHA8
EPN1
EPN2
ERN1
ERVK13-1
EXOSC8
FAM111A
FAM175A
FAM175B
FBXO16
FBXO18
FBXO44
FETUB
FGA
FIS1
FOXO3
FSHR
GABBR1
GARNL3
GFPT2
GGA1
GGA3
GRAP2
GTF2IRD1
HACE1
HDAC5
HDAC6
HECW1
HENMT1
HERC3
HERC4
HGS
HIC1
HIST1H2AI
HIST1H4A
HIST2H2AC
HIST2H2BC
HIST2H2BE
HIST2H4A
HLTF
HMCN1
HOXA9
HRNR
HSPA8
HYDIN
HYDIN2
IDE
IGF1R
IKBKG
IL17B
IRF1
ISX
ITCH
JOSD2
KCNJ1
KCTD6
KDM2A
KDR
KEL
KIAA0586
KIAA1211
KLHL11
KLHL13
KLHL6
KLHL7
KMT2D
L1CAM
LALBA
LAPTM5
LARP1B
LIMA1
LOC100130417
LOC100272216
LTN1
LYZ
MAD1L1
MAN1A2
MAP3K11
MAP3K2
MAP3K3
MAPK4
MAPT
MARCH7
MARK4
MDFI
MDM4
MDN1
MED15
MFRP
MINPP1
MMP8
MOAP1
MPHOSPH9
MRPL37
MTERF4
MUC16
MUC5B
MUL1
MVB12A
MYOCD
N4BP1
NAE1
NAV3
NBPF1
NBPF10
NBPF11
NBPF12
NBPF14
NBPF8
NBPF9
NCKAP5L
NCOA6
NDC1
NEDD4
NEDD4L
NEK8
NEURL3
NHP2
NPLOC4
NR0B2
NR2C1
NT5C1B
NUAK1
NUAK2
OBP2B
OLFML2A
OPRM1
OPTN
OR7G3
OTOG
OTUB2
OTUD1
OTUD3
OTUD4
OTUD5
OTUD6A
OTUD7A
OTUD7B
OTULIN
P4HTM
PA2G4
PABPC4
PARK2
PARP10
PARVA
PBLD
PCNP
PDE12
PDS5A
PELI1
PHF20L1
PINK1
PJA1
PJA2
PLAA
POLH
POLI
POLR2A
POP5
PPARG
PPARGC1A
PPL
PPM1D
PPP1R13B
PRAME
PRKCI
PRKDC
PRPF8
PRR23B
PSMC2
PSMC3
PSMD1
PSMD4
PTH1R
PTOV1
PUS7L
R3HDM4
RABEP1
RABEP2
RABGEF1
RAD18
RAD51B
RAF1
RARRES3
RASAL2
RB1CC1
RELA
RGPD3
RGS2
RIOK3
RND3
RNF11
RNF111
RNF112
RNF114
RNF125
RNF130
RNF167
RNF168
RNF169
RNF181
RNF20
RNF31
RNF4
RNF8
RPL7L1
RTTN
SBF2
SCT
SDK1
SEC61B
SEPT4
SEPT7P2
SF3A1
SF3B1
SF3B4
SFPQ
SGOL1
SH3KBP1
SHARPIN
SIAH1
SLC17A2
SLC22A18
SLC26A1
SLC35A5
SLC44A3
SLIT2
SLX4
SMAD1
SMURF1
SMURF2
SNCA
SNRNP25
SNRPA
SNTB2
SNTG1
SOCS5
SPAG1
SPARCL1
SPECC1L
SPTA1
SQSTM1
ST5
STAM
STAM2
STAMBP
STAT1
STAT4
STX8
SUCO
SUN5
SUOX
SYNE2
TAB2
TAB3
TAC3
TACC2
TAX1BP1
TBXAS1
TCHH
TCP10
THG1L
TIAM1
TLR8
TMEM132A
TMEM160
TNFAIP3
TNFAIP6
TNIP1
TNIP2
TNIP3
TOLLIP
TOM1
TOM1L2
TOPORS
TRA
TRAFD1
TRIM17
TRIM21
TRIM23
TRIM36
TRIM39
TRIM41
TRIM49B
TRIM5
TRIM58
TRIM63
TSHR
TTC27
TTC28
TTC36
TTC39B
TTLL5
TUBA3D
TUBGCP2
TYW1
UBA1
UBA2
UBA3
UBAP1
UBASH3A
UBE2B
UBE2D1
UBE2D2
UBE2D3
UBE2E3
UBE2G2
UBE2J2
UBE2K
UBE2L3
UBE2L6
UBE2M
UBE2N
UBE2R2
UBE2S
UBE2V1
UBE2V2
UBE3A
UBE3C
UBFD1
UBL7
UBQLN1
UBR1
UBR3
UBR4
UBR5
UCHL1
UCHL3
UEVLD
UNC79
UNC93B3
USP1
USP10
USP11
USP12
USP13
USP14
USP15
USP16
USP17L2
USP19
USP2
USP21
USP22
USP25
USP28
USP3
USP33
USP4
USP46
USP48
USP5
USP7
USP8
USP9X
USP9Y
UTRN
VCPIP1
VMP1
VPS36
VPS37C
VPS9D1
WDR20
WDR88
WFDC8
WNK1
WWP1
WWP2
XIAP
XPNPEP1
YBX1
YOD1
YWHAB
YWHAG
YWHAZ
ZBTB1
ZC3H12A
ZC3H13
ZC3HC1
ZCWPW2
ZFAND3
ZFAND6
ZFYVE9
ZNF148
ZNF200
ZNF213
ZNF451
ZNF705G
ZNF716
ZNF789
ZNF792
ZNRF1
ZRANB1
ZSWIM2
ZW10
Entrez ID
201626
7316
HPRD ID
11842
07038
Ensembl ID
ENSG00000150991
Uniprot IDs
Q6L8Q7
F5H041
L8B4I8
PDB IDs
Enriched GO Terms of Interacting Partners
?
Viral Protein Processing
Notch Receptor Processing
Virion Assembly
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Glycogen Biosynthetic Process
Intracellular Transport Of Virus
Cellular Polysaccharide Biosynthetic Process
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Polysaccharide Biosynthetic Process
Negative Regulation Of Type I Interferon Production
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of ERBB Signaling Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Regulation Of DNA-templated Transcription In Response To Stress
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint
I-kappaB Kinase/NF-kappaB Signaling
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Toll-like Receptor 2 Signaling Pathway
Signal Transduction Involved In DNA Damage Checkpoint
Toll-like Receptor 9 Signaling Pathway
Signal Transduction Involved In Cell Cycle Checkpoint
Glycogen Metabolic Process
TRIF-dependent Toll-like Receptor Signaling Pathway
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Ubiquitin-protein Transferase Activity
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Mitotic G1 DNA Damage Checkpoint
Positive Regulation Of Ubiquitin-protein Transferase Activity
Mitotic G1/S Transition Checkpoint
G1 DNA Damage Checkpoint
Positive Regulation Of Cell Cycle Arrest
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Ligase Activity
Positive Regulation Of Type I Interferon Production
DNA Damage Response, Signal Transduction By P53 Class Mediator
Toll-like Receptor 4 Signaling Pathway
Regulation Of ERBB Signaling Pathway
Polysaccharide Metabolic Process
Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Protein Modification By Small Protein Conjugation
Protein Ubiquitination
Modification-dependent Protein Catabolic Process
Cellular Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Protein Catabolic Process
Cellular Protein Modification Process
Cellular Macromolecule Catabolic Process
Protein Deubiquitination
Protein Polyubiquitination
Protein Modification By Small Protein Removal
Proteolysis
Cellular Protein Metabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Catabolic Process
Protein Metabolic Process
Cellular Metabolic Process
Regulation Of Protein Catabolic Process
Regulation Of Protein Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Protein K63-linked Deubiquitination
Regulation Of Proteasomal Protein Catabolic Process
Protein K48-linked Ubiquitination
Regulation Of Proteolysis
Cellular Process
Cellular Response To Stress
Protein K48-linked Deubiquitination
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Ubiquitination
Regulation Of Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Response To Stress
Regulation Of Signal Transduction
Cell Cycle
Metabolic Process
Protein K63-linked Ubiquitination
Apoptotic Process
Regulation Of Signaling
Cell Death
Death
Cellular Response To Stimulus
Positive Regulation Of Metabolic Process
Programmed Cell Death
Response To Stimulus
Cell Cycle Process
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Positive Regulation Of Protein Ubiquitination
Tagcloud
?
3p24
amino
assigned
bond
cdna
conjugating
drosophila
e1
e2
encoding
enzyme
extension
fluorescence
formed
hybridization
identity
kb
product
shares
similarity
thioester
transcribed
transcript
ubcd2
ubch6
ubch8
ubcm2
ube2e2
ubiquitin
Tagcloud (Difference)
?
3p24
amino
assigned
bond
cdna
conjugating
drosophila
e1
e2
encoding
enzyme
extension
fluorescence
formed
hybridization
identity
kb
product
shares
similarity
thioester
transcribed
transcript
ubcd2
ubch6
ubch8
ubcm2
ube2e2
ubiquitin
Tagcloud (Intersection)
?