PDE12 and DNAH12

Data Source: HiPPIP (Novel)

		PDE12	DNAH12
Name		phosphodiesterase 12	dynein axonemal heavy chain 12
Structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Cytosol	Cytoplasm Cytoskeleton Axonemal Dynein Complex Microtubule Cilium Dynein Complex Cell Projection
	Molecular Function	3'-5'-RNA Exonuclease Activity Catalytic Activity Nuclease Activity Exonuclease Activity Poly(A)-specific Ribonuclease Activity Hydrolase Activity Metal Ion Binding	Nucleotide Binding ATP Binding Minus-end-directed Microtubule Motor Activity Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Mitochondrial MRNA Catabolic Process MRNA Processing Cellular Response To Interferon-alpha Regulation Of Mitochondrial MRNA Stability Positive Regulation Of Viral Genome Replication Defense Response To Virus Cellular Response To Type II Interferon Cellular Response To DsRNA Nucleic Acid Metabolic Process Antiviral Innate Immune Response	Cilium Movement Microtubule-based Movement Axonemal Dynein Complex Assembly
Pathways		OAS antiviral response	None
GWAS		No GWAS studies recorded	Appendicular lean mass ( 33097823 ) Lung function (FEV1) ( 30061609 ) Monocyte percentage of white cells ( 32888494 ) Working memory ( 31598132 )
Interacting Genes		2 interacting genes: FBXO7 UBC	None recorded
Entrez ID		201626	201625
HPRD ID		11842	08281
Ensembl ID		ENSG00000174840	ENSG00000174844
Uniprot IDs		F6T1Q0 Q6L8Q7	E9PG32 Q6ZR08
PDB IDs		4Z0V 4Z2B 4ZKF	8J07
GO Terms Enriched among Interactors		Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Lewy Body Core Ubiquitin Protein Ligase Binding Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Modification-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Tag Activity Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitophagy Positive Regulation Of Autophagy Of Mitochondrion Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Minus-end-directed Microtubule Motor Activity Dynein Light Intermediate Chain Binding Axonemal Dynein Complex Protein Targeting To Mitochondrion Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Dynein Intermediate Chain Binding Axonemal Dynein Complex Assembly Dynein Complex Post-translational Protein Modification	Regulation Of Mitochondrial MRNA Stability Mitochondrial RNA Catabolic Process Mitochondrial MRNA Catabolic Process Poly(A)-specific Ribonuclease Activity Cellular Response To Interferon-alpha Cellular Response To DsRNA Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Response To Interferon-alpha 3'-5'-RNA Exonuclease Activity Positive Regulation Of Viral Genome Replication Response To DsRNA Exonuclease Activity Mitochondrial RNA Metabolic Process Positive Regulation Of Viral Process Antiviral Innate Immune Response Regulation Of Viral Genome Replication Cellular Response To Type II Interferon Positive Regulation Of MRNA Catabolic Process MRNA Destabilization RNA Destabilization Response To Type II Interferon Regulation Of Viral Life Cycle Nuclear-transcribed MRNA Catabolic Process Nuclease Activity MRNA Catabolic Process Regulation Of Viral Process Positive Regulation Of MRNA Metabolic Process RNA Catabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability