PDE12

Name	phosphodiesterase 12
Structure
Novel Interactors	1 novel interactors: DNAH12
Interactors	2 interactors: FBXO7 UBC
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function	3'-5'-RNA Exonuclease Activity Catalytic Activity Nuclease Activity Exonuclease Activity Poly(A)-specific Ribonuclease Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Mitochondrial MRNA Catabolic Process MRNA Processing Cellular Response To Interferon-alpha Regulation Of Mitochondrial MRNA Stability Positive Regulation Of Viral Genome Replication Defense Response To Virus Cellular Response To Type II Interferon Cellular Response To DsRNA Nucleic Acid Metabolic Process Antiviral Innate Immune Response
Pathways	OAS antiviral response
GWAS	No GWAS studies recorded
Entrez ID	201626
HPRD ID	11842
Ensembl ID	ENSG00000174840
Uniprot IDs	F6T1Q0 Q6L8Q7
PDB IDs	4Z0V 4Z2B 4ZKF
GO Terms Enriched among Interactors ?	Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Lewy Body Core Ubiquitin Protein Ligase Binding Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Modification-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Tag Activity Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitophagy Positive Regulation Of Autophagy Of Mitochondrion Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Minus-end-directed Microtubule Motor Activity Dynein Light Intermediate Chain Binding Axonemal Dynein Complex Protein Targeting To Mitochondrion Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Dynein Intermediate Chain Binding Axonemal Dynein Complex Assembly Dynein Complex Post-translational Protein Modification