ZSCAN4 and HAT1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZSCAN4	HAT1
Description		zinc finger and SCAN domain containing 4	histone acetyltransferase 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Chromosome	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Nuclear Matrix Protein-containing Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Histone Acetyltransferase Activity Protein Binding Histone H4 Acetyltransferase Activity Transferase Activity Acyltransferase Activity Histone Binding Histone H4K12 Acetyltransferase Activity Protein-lysine-acetyltransferase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Mitotic Recombination	Chromatin Organization Nucleosome Assembly Internal Protein Amino Acid Acetylation Subtelomeric Heterochromatin Formation Chromosome Organization
Pathways		Zygotic genome activation (ZGA)	HATs acetylate histones
Drugs
Diseases
GWAS			Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Myopia ( 27182965) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		13 interacting genes: CIB3 CTBP2 EXOC8 FAM110A HAT1 HCK KAT5 LAMTOR3 PARD6B SMAD1 SMAD9 TBC1D22B TRAF3	23 interacting genes: ACAA1 CEBPA EZH2 H2AC20 H3-4 H3C1 H4C14 H4C16 HTR2B KANK4 MEOX2 MORN5 PRKAA2 REL SMAD7 SNAPC1 STEEP1 TCF4 TEPSIN TNFAIP1 TRIB3 YWHAQ ZSCAN4
Entrez ID		201516	8520
HPRD ID		15899	04339
Ensembl ID		ENSG00000180532	ENSG00000128708
Uniprot IDs		Q8NAM6	A0AAG2UVM1 O14929
PDB IDs			2P0W 6VO5 9MJG
Enriched GO Terms of Interacting Partners?		Heteromeric SMAD Protein Complex SMAD Protein Complex Histone H4 Acetyltransferase Activity I-SMAD Binding SMAD Protein Signal Transduction Protein-lysine-acetyltransferase Activity Innate Immune Response-activating Signaling Pathway Histone Acetyltransferase Activity Protein Acetylation Activation Of Innate Immune Response Transcription Regulator Complex Histone H2AK5 Acetyltransferase Activity	Structural Constituent Of Chromatin Protein Heterodimerization Activity Nucleosome Chromosome, Telomeric Region Protein-DNA Complex Assembly DNA Binding Nucleosome Assembly Negative Regulation Of Chondrocyte Proliferation Negative Regulation Of Cell Differentiation Sequence-specific DNA Binding Chromatin Remodeling Chromosome Nucleosome Organization Telomere Organization Protein Localization To Chromatin Chromatin Organization Regulation Of Cell Differentiation Nucleus Nucleoplasm Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Developmental Process CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Megakaryocyte Differentiation Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Stem Cell Differentiation Regulation Of Macromolecule Metabolic Process Protein Localization To Chromosome Protein-containing Complex Cardiac Muscle Hypertrophy Positive Regulation Of Proteasomal Protein Catabolic Process Muscle Hypertrophy Regulation Of Cell Development Positive Regulation Of Cartilage Development Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Metabolic Process Acetate CoA-transferase Activity Phenylacetate Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Hepatocyte Homeostasis Beta-catenin Destruction Complex Disassembly Positive Regulation Of Chondrocyte Hypertrophy Chromosome Organization Protein Localization To Chromosome, Centromeric Region Regulation Of Megakaryocyte Differentiation Coated Vesicle Membrane
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