MIR140 and CELF2

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		MIR140	CELF2
Description		microRNA 140	CUGBP Elav-like family member 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space RISC Complex	Nucleus Nucleoplasm Cytoplasm Flemming Body Ribonucleoprotein Complex
	Molecular Function	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity	Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Pre-mRNA Binding
	Biological Process	Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of BMP Signaling Pathway Negative Regulation Of Chemokine Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor 4 Signaling Pathway MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By MRNA Destabilization Defense Response To Bacterium Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Osteoblast Differentiation Negative Regulation Of SMAD Protein Signal Transduction Cellular Response To Lipopolysaccharide Cellular Response To Hypoxia Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Vascular Endothelial Growth Factor Production Cellular Response To Amyloid-beta Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splice Site Recognition RNA Processing MRNA Processing Regulation Of Heart Contraction
Pathways
Drugs
Diseases
GWAS		Body mass index ( 26426971)	Activity variability during wake ( 33075057) Adult body size ( 32376654) Adventurousness ( 30643258) Adverse response to drug ( 30420678) Age at first sexual intercourse ( 34211149) Allergic rhinitis ( 30013184) Asthma ( 29273806 34103634) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Basal cell carcinoma ( 33549134) Body size at age 10 ( 32376654) Breastfeeding duration ( 25475840) Chronic kidney disease ( 31015462) Cognitive function in longevity ( 33607172) General risk tolerance (MTAG) ( 30643258) Glaucoma (primary open-angle) ( 33627673) Glycemic traits (pleiotropy) ( 31021400) Liver enzyme levels (alanine transaminase) ( 24124411) Liver enzyme levels (aspartate transaminase) ( 24124411) Mean platelet volume ( 32888494) Motion sickness ( 25628336) Obesity-related traits ( 23251661) Offspring birth weight ( 31043758) Pulse pressure ( 30224653) Response to lamotrigine in genetic generalized epilepsy ( 32308125) Urinary albumin-to-creatinine ratio ( 26631737)
Interacting Genes		68 interacting genes: ADARB1 AIMP1 APOBEC3B C1QBP CELF1 CELF2 CRTAP CSTF1 DARS1 DDX1 DDX21 DDX3X DDX49 EIF2AK2 EPRS1 FAM98A FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LIN28A LRPPRC MARS1 MATR3 NOL6 NONO NUDT21 PDCD11 PIKFYVE PIP5K1A PTBP1 PTBP3 PUF60 PUM1 PURA QARS1 RARS1 RBFOX2 RBM14 RTCB SF3B1 SF3B3 SFPQ SYNCRIP TAF15 TRA2A TRA2B UPF1 UTP20 YBX1 YBX3	23 interacting genes: A1CF APOBEC1 APP CEBPA ELAVL1 MIR140 MIR155 MIR18B MIR199A1 MIR19A MIR19B1 MIR205 MIR21 MIR29C MIR34B MIR363 MIR7-1 MIR9-2 MIRLET7I PCBP1 PTGS2 RNF10 TRAF3
Entrez ID		406932	10659
HPRD ID			03964
Ensembl ID		ENSG00000208017	ENSG00000048740
Uniprot IDs			A0A0J9YX66 A0A0J9YXJ0 A0A1B0GU44 A0A1B0GUN8 B4DDE7 B4DIB6 B4DT00 B4DZ01 E9PC62 O95319
PDB IDs			2MY7 2MY8 4LJM 4LMZ 4TLQ 5M8I
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process Nucleic Acid Metabolic Process MRNA Processing RNA Splicing MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of MRNA Metabolic Process Regulation Of RNA Splicing MRNA Binding Macromolecule Metabolic Process Ribonucleoprotein Complex MRNA Splicing, Via Spliceosome Nucleus RNA Splicing, Via Transesterification Reactions Aminoacyl-tRNA Synthetase Multienzyme Complex Regulation Of MRNA Splicing, Via Spliceosome Nucleoplasm Post-transcriptional Regulation Of Gene Expression Regulation Of MRNA Processing Negative Regulation Of MRNA Metabolic Process MRNA 3'-UTR Binding Spliceosomal Complex Regulation Of Gene Expression Catalytic Step 2 Spliceosome Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cytoplasmic Stress Granule Regulation Of Primary Metabolic Process Regulation Of Translation Regulation Of Metabolic Process Negative Regulation Of MRNA Catabolic Process Regulation Of RNA Stability Negative Regulation Of RNA Catabolic Process MRNA Stabilization Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of Macromolecule Metabolic Process Regulation Of MRNA Stability RNA Stabilization Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process MiRNA Binding TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Negative Regulation Of Translation Regulation Of Nucleobase-containing Compound Metabolic Process TRNA Aminoacylation Nucleolus	Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression RISC Complex MRNA 3'-UTR Binding Negative Regulation Of Gene Expression Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Multicellular Organismal Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Developmental Process Regulation Of Extracellular Matrix Organization Negative Regulation Of Endothelial Cell Migration Regulation Of Cardiac Muscle Hypertrophy Regulation Of Defense Response Regulation Of Inflammatory Response Regulation Of Cytokine Production Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Matrix Metallopeptidase Secretion Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Extracellular Vesicle Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Striated Muscle Cell Apoptotic Process Regulation Of MRNA Metabolic Process Regulation Of MRNA Stability MRNA Destabilization Negative Regulation Of Cell Migration Regulation Of Endothelial Cell Migration MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Cell Population Proliferation RNA Destabilization Negative Regulation Of Cytokine Production Negative Regulation Of Cell Motility Regulation Of RNA Stability Regulation Of Developmental Process Regulation Of Cell Population Proliferation
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