ELAVL2 and NR2E3

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		ELAVL2	NR2E3
Description		ELAV like RNA binding protein 2	nuclear receptor subfamily 2 group E member 3
Image		No pdb structure
GO Annotations	Cellular Component	Ribonucleoprotein Complex	Nucleus Nucleoplasm Transcription Regulator Complex
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Regulation Of DNA-templated Transcription	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Signal Transduction Visual Perception Phototransduction Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Neuron Differentiation Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Intracellular Receptor Signaling Pathway Eye Photoreceptor Cell Development Positive Regulation Of Transcription By RNA Polymerase II Retina Development In Camera-type Eye
Pathways
Drugs
Diseases			Retinitis pigmentosa (RP) Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC)
GWAS		Anxiety ( 33859377) Asthma ( 34103634 30929738) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Attending social / leisure activities ( 34054130) Body mass index ( 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically inactive individuals ( 28448500) Chronic obstructive pulmonary disease ( 30804561) Feeling guilty ( 29500382) Femur bone mineral density x serum urate levels interaction ( 34046847) Fulminant type 1 diabetes ( 30552108) General cognitive ability ( 29844566) Glomerular filtration rate change in heart transplantation ( 30160337) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Intelligence (MTAG) ( 29326435) Lung function (FEV1/FVC) ( 30061609) Neurociticism ( 29500382) Neuroticism ( 27067015 29255261 27089181) Physiological traits ( 31902109) Plasma t-tau levels ( 28100725) Remission after SSRI treatment in MDD or neuroticism ( 29559929) Schizophrenia ( 33169155) Sociability score ( 34054130)	Hematocrit ( 32888494) Hemoglobin ( 32888494) Macular thickness ( 30535121) Metabolite levels (HVA/MHPG ratio) ( 23319000) Red blood cell count ( 32888494)
Interacting Genes		6 interacting genes: ELAVL3 ELAVL4 HNRNPAB HOXC9 NR2E3 RBFOX2	29 interacting genes: BCL11A CDK9 CRX DEDD2 DHX30 ELAVL2 HDAC1 HDAC3 HOXC13 IRF9 MYBBP1A NCOR1 NR1D1 NR3C1 NRL POLR3D PPARG RARA RBBP4 RBBP7 RBFOX2 RBL1 RXRA RXRB SIN3A SNAPC1 TBL3 WDR5 ZNF232
Entrez ID		1993	10002
HPRD ID		03396	05132
Ensembl ID		ENSG00000107105	ENSG00000278570
Uniprot IDs		A0A0A0MRX1 Q12926	F1D8Q9 Q9Y5X4
PDB IDs			4LOG
Enriched GO Terms of Interacting Partners?		Negative Regulation Of MRNA Catabolic Process Regulation Of MRNA Metabolic Process Negative Regulation Of RNA Catabolic Process Negative Regulation Of MRNA Metabolic Process Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Ribonucleoprotein Complex MRNA 3'-UTR Binding Developmental Process MRNA 3'-UTR AU-rich Region Binding Nucleic Acid Binding Cellular Developmental Process MRNA Binding Negative Regulation Of RNA Metabolic Process RNA Metabolic Process MRNA Stabilization Cell Differentiation RNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process RNA Stabilization Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Pre-mRNA Intronic Pyrimidine-rich Binding Negative Regulation Of Catabolic Process Nuclear Receptor-mediated Signaling Pathway Cellular Response To Cell-matrix Adhesion MRNA Editing Complex Interleukin-11 Receptor Activity Interleukin-11 Binding Selenocysteine Insertion Sequence Binding Chromosomal 5-methylcytosine DNA Demethylation Pathway Hormone-mediated Signaling Pathway Positive Regulation Of 3'-UTR-mediated MRNA Stabilization Nucleic Acid Metabolic Process Regulation Of Intracellular MRNA Localization Neuronal Ribonucleoprotein Granule Positive Regulation Of Gene Expression Interleukin-11-mediated Signaling Pathway MRNA Metabolic Process Neuron Development Selenocysteine Incorporation Regulation Of MRNA Stability Regulation Of RNA Metabolic Process Regulation Of RNA Stability Megakaryocyte Differentiation Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Intracellular Receptor Signaling Pathway	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process DNA Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription Cis-regulatory Region Binding Nucleus Positive Regulation Of RNA Metabolic Process Histone Deacetylase Complex Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Nuclear Receptor Activity Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Chromatin Binding Hormone-mediated Signaling Pathway DNA-binding Transcription Factor Activity Negative Regulation Of Macromolecule Metabolic Process Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Sin3-type Complex Chromatin Organization Retinoic Acid Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Metabolic Process Retinoic Acid-responsive Element Binding Nucleic Acid Metabolic Process
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